Thienopyridine and benzofuran derivatives as potent anti-tumor agents possessing different structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 13, 2004, Pages 3411-3414

  Hayakawa, Ichiro ^a   Shioya, Rieko ^a   Agatsuma, Toshinori ^a   Furukawa, Hidehiko ^a   Sugano, Yuichi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Anticancer; Lead compound; SAR

Indexed keywords

(3 AMINO 6 THIOPHEN 2 YLTHIENO[2,3 B]PYRIDIN 2 YL)PHENYLMETHANONE; (4 HYDROXY 3 METHYL 6 PHENYLBENZOFURAN 2 YL)PHENYLMETHANONE; BENZOFURAN DERIVATIVE; CYTOTOXIC AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOFURANS; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2942615468     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.079     Document Type: Article

References (11)

1. Hayakawa I., Shioya R., Agatsuma T., Furukawa H., Naruto S., Sugano Y. Bioorg. Med. Chem. Lett. 14:2004;455
2. US Patent Application US60/306116, July 17, 2001
3. Moryashova S.I., Salamandra L.K., Fedorov A.E., Rodinovskaya L.A., Shestopalov A.M., Semenov V.V. Russ. Chem. Bull. 47:1998;357
4. Moryashova S.I., Salamandra L.K., Fedorov A.E., Rodinovskaya L.A., Shestopalov A.M., Semenov V.V. Izv. Akad. Nauk Ser. Khim. 2:1998;365
5. SYBYL 6.6 (Tripos, Inc.) was used as a front-end
6. Streitwieser A., Heathcook C.H., Kosower E.M. Introduction to Organic Chemistry. 4th ed. 1992;Macmillan Publishing Co. New York, NY. pp 1051-1052
7. The tested compounds were purchased from ChemBridge Corporation, San Diego, CA, USA
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