Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 463-470

  Hamdy, Nehal A ^a   Gamal Eldeen, Amira M ^a   Abdel Aziz, Hatem A ^a   Fakhr, Issa M I ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Carcinogen metabolizing enzymes; Imidazobenzimidazole; Imidazopyridine; Imidazotriazole; Indolizine; Pyrimidinum bromide; Quinoxaline

Indexed keywords

1 [2 OXO 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)ETHYL]PYRIDINIUM BROMIDE; 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL) 1H IMIDAZO[1,2 A]BENZIMIDAZOLE; 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)IMIDAZO[1,2 A]PYRIDINE; 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)QUINOXALINE; 2 BROMO 1 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)ETHANONE; 2 METHYL 1 [2 OXO 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)ETHYL]PYRIDINIUM BROMIDE; 3 (5,6,7,8 TETRAHYDRO NAPHTHALENE 2 CARBONYL)INDOLIZINE 1,2 DICARBOXYLIC ACID DIMETHYL ESTER; 4 METHYL 1 [2 OXO 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)ETHYL]PYRIDINIUM BROMIDE; 5 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL) 1H IMIDAZO[1,2 B][1,2,4]TRIAZOLE; 5 METHYL 3 (5,6,7,8 TETRAHYDRO NAPHTHALENE 2 CARBONYL)INDOLIZINE 1,2 DICARBOXYLIC ACID DIMETHYL ESTER; 6 BROMO 2 (5,6,7,8 TETRAHYDRO NAPHTHALEN 2 YL)IMIDAZO[1,2 A]PYRIDINE; 7 METHYL 3 (5,6,7,8 TETRAHYDRO NAPHTHALENE 2 CARBONYL)INDOLIZINE 1,2 DICARBOXYLIC ACID DIMETHYL ESTER; ACETYLENE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BROMINE DERIVATIVE; CARCINOGEN; CYTOCHROME P450 1A; DNA; ENZYME; EPOXIDE HYDROLASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INDOLIZINE DERIVATIVE; OXIDOREDUCTASE; PYRIDINE; PYRROLE DERIVATIVE; QUINOXALINE; SODIUM CHLORIDE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN;

ANIMALS; ANTIOXIDANTS; CARCINOGENS; CELL LINE, TUMOR; DNA DAMAGE; ENZYME INDUCTION; ENZYMES; HETEROCYCLIC COMPOUNDS; HUMANS; MICE; NEOPLASMS; TETRAHYDRONAPHTHALENES;

EID: 73549097281     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.027     Document Type: Article

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