New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4547-4556

  Hamdy, Nehal A ^a   Gamal Eldeen, Amira M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

5 Lipoxygenase; Anti inflammatory; Cycloxygenase 2; Pyrazolopyridine; Pyridine; Pyridone; Thioxopyridine

Indexed keywords

2 BENZYLAMINO 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)NICOTINONITRILE; 2 BENZYLAMINO 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)NICOTINONITRILE; 2 CHLORO 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)NICOTINONITRILE; 2 CHLORO 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)NICOTINONITRILE; 4 (1H INDOL 3 YL) 2 OXO 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4 (3,4 DIMETHOXY PHENYL) 2 OXO 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YLAMINE; 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 2 THIOXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4 (4 ISOPROPYL PHENYL) 2 OXO 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YLAMINE; 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 2 THIOXO 1,2 DIHYDRO PYRIDINE 3 CARBONITRILE; [3 CYANO 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETIC ACID ETHYL ESTER; [3 CYANO 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETIC ACID HYDRAZIDE; [3 CYANO 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETIC ACID ETHYL ESTER; [3 CYANO 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETIC ACID HYDRAZIDE; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2; N BENZYL 2 [3 CYANO 4 (4 ISOPROPYLPHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETAMIDE; N BENZYL 2 [3CYANO 4 (3,4 DIMETHOXY PHENYL) 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDIN 2 YLOXY]ACETAMIDE; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; CELL PROLIFERATION; CYCLOOXYGENASE 2; MACROPHAGES; MICE; PHAGOCYTOSIS; PYRIDINES; PYRIDONES; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 70349772977     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.023     Document Type: Article

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