Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

Biochemical Journal

Volumn 459, Issue 1, 2014, Pages 59-69

  Chaikuad, Apirat ^a   Keates, Tracy ^a   Vincke, Cécile ^b   Kaufholz, Melanie ^c   Zenn, Michael ^d   Zimmermann, Bastian ^d   Gutiérrez, Carlos ^e   Zhang, Rong Guang ^f   Hatzos Skintges, Catherine ^f   Joachimiak, Andrzej ^f   Muyldermans, Serge ^b   Herberg, Friedrich W ^c,d   Knapp, Stefan ^a   Müller, Susanne ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c UNIVERSITY OF KASSEL   (Germany)

^d Biaffin GmbH and CoKG   (Germany)

^e UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^f ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

Activation loop; Cyclin G associated kinase; Drug side effect; Kinase inhibitor; Nanobody; Protein structure

Indexed keywords

CYCLIN G; CYCLIN G ASSOCIATED KINASE; NANOBODY; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPROTEINS; CAMELS; CATALYTIC DOMAIN; CRYSTALLIZATION; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN-SERINE-THREONINE KINASES; SINGLE-DOMAIN ANTIBODIES;

EID: 84896138811     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131399     Document Type: Article

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