Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Tabara, Hiroe ^a   Naito, Yoko ^a   Ito, Akihiko ^b   Katsuma, Asako ^a   Sakurai, Minami A ^a   Ohno, Shouichi ^a   Shimizu, Hiroyuki ^a   Yabuta, Norikazu ^a   Nojima, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN G ASSOCIATED KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; SURFACTANT PROTEIN A; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; GAK PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; QUINAZOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LETHALITY; LUNG ALVEOLUS; LUNG ALVEOLUS CELL; LUNG DISEASE; LUNG NON SMALL CELL CANCER; MOUSE; NEWBORN; NEWBORN DEATH; NONHUMAN; PROTEIN EXPRESSION; PUP (RODENT); RESPIRATORY FAILURE; SIDE EFFECT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANIMAL EMBRYO; CELL MEMBRANE; CESAREAN SECTION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FIBROBLAST; GENE SILENCING; GROWTH, DEVELOPMENT AND AGING; LUNG; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

MUS;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; CADHERINS; CELL MEMBRANE; CESAREAN SECTION; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; LUNG; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 80053997817     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026034     Document Type: Article

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