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Volumn , Issue , 2012, Pages 171-182

MRP2 (ABCC2) and disorders of bilirubin handling in liver

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EID: 84896114627     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (1)

References (88)
  • 1
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • Jedlitschky G, Leier I, Buchholz U, et al. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J. 1997;327:305-10.
    • (1997) Biochem. J , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3
  • 2
    • 0032769284 scopus 로고    scopus 로고
    • Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
    • Kamisako T, Leier I, Cui Y, et al. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology 1999;30:485-90.
    • (1999) Hepatology , vol.30 , pp. 485-490
    • Kamisako, T.1    Leier, I.2    Cui, Y.3
  • 3
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • Kartenbeck J, Leuschner U, Mayer R, et al. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996;23:1061-6.
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3
  • 4
    • 1942435578 scopus 로고    scopus 로고
    • Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)
    • Lee YM, Cui Y König J, et al. Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3). Pharmacogenetics 2004;14:213-23.
    • (2004) Pharmacogenetics , vol.14 , pp. 213-223
    • Lee, Y.M.1    Cui, Y.2    König, J.3
  • 5
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • König J, Cui Y, Nies AT, et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 2000;278:G156-64.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol , vol.278 , pp. G156-G164
    • König, J.1    Cui, Y.2    Nies, A.T.3
  • 6
    • 0035971239 scopus 로고    scopus 로고
    • Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
    • Cui Y, König J, Leier I, et al. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 2001;276:9626-30.
    • (2001) J. Biol. Chem , vol.276 , pp. 9626-9630
    • Cui, Y.1    König, J.2    Leier, I.3
  • 7
  • 8
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • Cui Y, König J, Buchholz J, et al. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharmacol. 1999;55:929-37.
    • (1999) Mol. Pharmacol , vol.55 , pp. 929-937
    • Cui, Y.1    König, J.2    Buchholz, J.3
  • 9
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui Y, König J, Keppler D. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol. Pharmacol. 2001;60:934-43.
    • (2001) Mol. Pharmacol , vol.60 , pp. 934-943
    • Cui, Y.1    König, J.2    Keppler, D.3
  • 10
    • 18044372268 scopus 로고    scopus 로고
    • Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2
    • Letschert K, Komatsu M, Hummel-Eisenbeiss J, et al. Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2. J. Pharmacol. Exp. Ther. 2005;313:549-56.
    • (2005) J. Pharmacol. Exp. Ther , vol.313 , pp. 549-556
    • Letschert, K.1    Komatsu, M.2    Hummel-Eisenbeiss, J.3
  • 11
  • 12
    • 0033998261 scopus 로고    scopus 로고
    • MRP2, a human conjugate export pump, is present and transports Fluo-3 into apical vacuoles of HepG2 cells
    • Cantz T, Nies AT, Brom M, et al. MRP2, a human conjugate export pump, is present and transports Fluo-3 into apical vacuoles of HepG2 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2000;278:G522-31.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol , vol.278 , pp. G522-G531
    • Cantz, T.1    Nies, A.T.2    Brom, M.3
  • 13
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multi-drug resistance proteins MRP1 and MRP2
    • Hooijberg JH, Broxterman HJ, Kool M, et al. Antifolate resistance mediated by the multi-drug resistance proteins MRP1 and MRP2. Cancer Res. 1999;59:2532-5.
    • (1999) Cancer Res , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3
  • 14
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutants rats caused by defective hepatic anion transport
    • Jansen PLM, Peters WHM, Lamers WH. Hereditary chronic conjugated hyperbilirubinemia in mutants rats caused by defective hepatic anion transport. Hepatology 1985;5:573-9.
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansen, P.L.M.1    Peters, W.H.M.2    Lamers, W.H.3
  • 15
    • 0023185436 scopus 로고
    • Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion
    • Huber M, Guhlmann A, Jansen PL, et al. Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology 1987;7:224-8.
    • (1987) Hepatology , vol.7 , pp. 224-228
    • Huber, M.1    Guhlmann, A.2    Jansen, P.L.3
  • 16
    • 0029082150 scopus 로고
    • Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
    • Oude Elferink RPJ, Meijer DKF, Kuipers F, et al. Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport. Biochim. Biophys. Acta 1995;1241:215-68.
    • (1995) Biochim. Biophys. Acta , vol.1241 , pp. 215-268
    • Oude Elferink, R.P.J.1    Meijer, D.K.F.2    Kuipers, F.3
  • 17
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene
    • Paulusma CC, Bosma PJ, Zaman GJR, et al. Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene. Science 1996;271:1126-8.
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.R.3
  • 18
    • 0040761368 scopus 로고    scopus 로고
    • CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Büchler M, König J, Brom M, et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 1996;271:15091-8.
    • (1996) J. Biol. Chem , vol.271 , pp. 15091-15098
    • Büchler, M.1    König, J.2    Brom, M.3
  • 19
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
    • Ito K, Suzuki H, Hirohashi T, et al. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 1997;272:G16-22.
    • (1997) Am. J. Physiol , vol.272 , pp. G16-G22
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3
  • 20
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • König J, Nies AT, Cui Y, et al. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta 1999;1461:377-94.
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 377-394
    • König, J.1    Nies, A.T.2    Cui, Y.3
  • 21
    • 0029133131 scopus 로고
    • Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
    • Mayer R, Kartenbeck J, Büchler M, et al. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol. 1995;131:137-50.
    • (1995) J. Cell Biol , vol.131 , pp. 137-150
    • Mayer, R.1    Kartenbeck, J.2    Büchler, M.3
  • 22
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi K, Wada M, Kohno K, et al. A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 1996;56:4124-29.
    • (1996) Cancer Res , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3
  • 23
    • 0030994468 scopus 로고    scopus 로고
    • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    • Paulusma CC, Kool M, Bosma PJ, et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997;25:1539-42.
    • (1997) Hepatology , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3
  • 24
    • 0001308329 scopus 로고    scopus 로고
    • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    • Evers R, Kool M, van Deemter L, et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J. Clin. Invest. 1998;101:1310-19.
    • (1998) J. Clin. Invest , vol.101 , pp. 1310-1319
    • Evers, R.1    Kool, M.2    van Deemter, L.3
  • 26
    • 0033214154 scopus 로고    scopus 로고
    • Purification of the human apical conjugate export pump MRP2. Reconstitution and functional characterization as substrate-stimulated ATPase
    • Hagmann W, Nies AT, König J, et al. Purification of the human apical conjugate export pump MRP2. Reconstitution and functional characterization as substrate-stimulated ATPase. Eur. J. Biochem. 1999;265:281-9.
    • (1999) Eur. J. Biochem , vol.265 , pp. 281-289
    • Hagmann, W.1    Nies, A.T.2    König, J.3
  • 27
    • 0036347975 scopus 로고    scopus 로고
    • Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes
    • Hagmann W, Schubert J, König J, et al. Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. Biol. Chem. 2002;383:1001-9.
    • (2002) Biol. Chem , vol.383 , pp. 1001-1009
    • Hagmann, W.1    Schubert, J.2    König, J.3
  • 28
    • 0029849789 scopus 로고    scopus 로고
    • The canalicular conjugate export pump encoded by the cmrp/cmoat gene
    • In: Boyer JL, Ockner RK, eds. Philadelphia: Saunders
    • Keppler D, Kartenbeck J. The canalicular conjugate export pump encoded by the cmrp/cmoat gene. In: Boyer JL, Ockner RK, eds. Progress in Liver Diseases. Vol. 14. Philadelphia: Saunders, 1996:55-67.
    • (1996) Progress in Liver Diseases , vol.14 , pp. 55-67
    • Keppler, D.1    Kartenbeck, J.2
  • 29
    • 0030832802 scopus 로고    scopus 로고
    • Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
    • Schaub TP, Kartenbeck J, König J, et al. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J. Am. Soc. Nephrol. 1997;8:1213-21.
    • (1997) J. Am. Soc. Nephrol , vol.8 , pp. 1213-1221
    • Schaub, T.P.1    Kartenbeck, J.2    König, J.3
  • 30
    • 0033032730 scopus 로고    scopus 로고
    • Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal-cell carcinoma
    • Schaub TP, Kartenbeck J, König J, et al. Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal-cell carcinoma. J. Am. Soc. Nephrol. 1999;10:1159-69.
    • (1999) J. Am. Soc. Nephrol , vol.10 , pp. 1159-1169
    • Schaub, T.P.1    Kartenbeck, J.2    König, J.3
  • 31
    • 0033724658 scopus 로고    scopus 로고
    • The effect of rifampin treatment on intestinal expression of human MRP transporters
    • Fromm MF, Kauffmann HM, Fritz P, et al. The effect of rifampin treatment on intestinal expression of human MRP transporters. Am. J. Pathol. 2000;157:1575-80.
    • (2000) Am. J. Pathol , vol.157 , pp. 1575-1580
    • Fromm, M.F.1    Kauffmann, H.M.2    Fritz, P.3
  • 32
    • 0035985610 scopus 로고    scopus 로고
    • Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays
    • Sandusky GE, Mintze KS, Pratt SE, et al. Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays. Histopathology 2002;41:65-74.
    • (2002) Histopathology , vol.41 , pp. 65-74
    • Sandusky, G.E.1    Mintze, K.S.2    Pratt, S.E.3
  • 33
    • 0034760443 scopus 로고    scopus 로고
    • Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia
    • Rost D, König J, Weiss G, et al. Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia. Gastroenterology 2001;121:1203-8.
    • (2001) Gastroenterology , vol.121 , pp. 1203-1208
    • Rost, D.1    König, J.2    Weiss, G.3
  • 35
    • 34447313404 scopus 로고    scopus 로고
    • The role of membrane transporters in drug delivery to brain tumors
    • Nies AT. The role of membrane transporters in drug delivery to brain tumors. Cancer Letters 2007;254:11-29.
    • (2007) Cancer Letters , vol.254 , pp. 11-29
    • Nies, A.T.1
  • 36
    • 0014608853 scopus 로고
    • Studies of bilirubin kinetics in normal adults
    • Berk PD, Howe RB, Bloomer JR, et al. Studies of bilirubin kinetics in normal adults. J. Clin. Invest. 1969;48:2176-90.
    • (1969) J. Clin. Invest , vol.48 , pp. 2176-2190
    • Berk, P.D.1    Howe, R.B.2    Bloomer, J.R.3
  • 38
    • 65249123179 scopus 로고    scopus 로고
    • Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
    • Sedlak TW, Saleh M, Higginson DS, et al. Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc. Natl. Acad. Sci. USA 2009;106:5171-6.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5171-5176
    • Sedlak, T.W.1    Saleh, M.2    Higginson, D.S.3
  • 39
    • 0001523675 scopus 로고
    • Biliary excretion of injected conjugated and unconju-gated bilirubin by normal and Gunn rats
    • Arias IM, Johnson L, Wolfson S. Biliary excretion of injected conjugated and unconju-gated bilirubin by normal and Gunn rats. Am. J. Physiol. 1961;200:1091-4.
    • (1961) Am. J. Physiol , vol.200 , pp. 1091-1094
    • Arias, I.M.1    Johnson, L.2    Wolfson, S.3
  • 40
    • 75449124849 scopus 로고
    • Metabolism and disposition of C14-bilirubin in congenital non-hemolytic jaundice
    • Schmid R, Hammaker L. Metabolism and disposition of C14-bilirubin in congenital non-hemolytic jaundice. J. Clin. Invest. 1963;42:1720-34.
    • (1963) J. Clin. Invest , vol.42 , pp. 1720-1734
    • Schmid, R.1    Hammaker, L.2
  • 41
    • 83755172199 scopus 로고    scopus 로고
    • Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF- B leads to hyperbilirubinemia
    • Fujiwara R, Chen S, Karin M, et al. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF- B leads to hyperbilirubinemia. Gastroenterology 2012;142:109-18.
    • (2012) Gastroenterology , vol.142 , pp. 109-118
    • Fujiwara, R.1    Chen, S.2    Karin, M.3
  • 42
    • 4644351861 scopus 로고    scopus 로고
    • Serum bilirubin levels in the U.S. population: Gender effect and inverse correlation with colorectal cancer
    • Zucker SD, Horn PS, Sherman KE. Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology 2004;40:827-35.
    • (2004) Hepatology , vol.40 , pp. 827-835
    • Zucker, S.D.1    Horn, P.S.2    Sherman, K.E.3
  • 43
    • 77953291331 scopus 로고    scopus 로고
    • Controversies in bilirubin biochemistry and their clinical relevance
    • McDonagh AF. Controversies in bilirubin biochemistry and their clinical relevance. Semin. Fetal Neonatal Med. 2010;15:141-7.
    • (2010) Semin. Fetal Neonatal Med , vol.15 , pp. 141-147
    • McDonagh, A.F.1
  • 44
    • 0033574696 scopus 로고    scopus 로고
    • Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes
    • Zucker SD, Goessling W, Hoppin AG. Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. J. Biol. Chem. 1999;274:10852-62.
    • (1999) J. Biol. Chem , vol.274 , pp. 10852-10862
    • Zucker, S.D.1    Goessling, W.2    Hoppin, A.G.3
  • 45
    • 0037907742 scopus 로고    scopus 로고
    • Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin
    • Briz O, Serrano MA, Macias RI, et al. Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem. J. 2003;371:897-905.
    • (2003) Biochem. J , vol.371 , pp. 897-905
    • Briz, O.1    Serrano, M.A.2    Macias, R.I.3
  • 46
    • 35549008848 scopus 로고    scopus 로고
    • OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation
    • Zhang W, He YJ, Gan Z, et al. OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation. Clin. Exp. Pharmacol. Physiol. 2007;34:1240-4.
    • (2007) Clin. Exp. Pharmacol. Physiol , vol.34 , pp. 1240-1244
    • Zhang, W.1    He, Y.J.2    Gan, Z.3
  • 47
    • 67649851008 scopus 로고    scopus 로고
    • Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
    • Sanna S, Busonero F, Maschio A, et al. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum. Mol. Genet. 2009;18:2711-18.
    • (2009) Hum. Mol. Genet , vol.18 , pp. 2711-2718
    • Sanna, S.1    Busonero, F.2    Maschio, A.3
  • 48
    • 67649838598 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis for total serum bilirubin levels
    • Johnson AD, Kavousi M, Smith AV, et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum. Mol. Genet. 2009;18:2700-10.
    • (2009) Hum. Mol. Genet , vol.18 , pp. 2700-2710
    • Johnson, A.D.1    Kavousi, M.2    Smith, A.V.3
  • 49
    • 77955300958 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
    • van de Steeg E, Wagenaar E, van der Kruijssen CM, et al. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J. Clin. Invest. 2010;120:2942-52.
    • (2010) J. Clin. Invest , vol.120 , pp. 2942-2952
    • van de Steeg, E.1    Wagenaar, E.2    van der Kruijssen, C.M.3
  • 50
    • 84856514936 scopus 로고    scopus 로고
    • Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
    • van de Steeg E, Stranecky V, Hartmannova H, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J. Clin. Invest. 2012;122:519-28.
    • (2012) J. Clin. Invest , vol.122 , pp. 519-528
    • van de Steeg, E.1    Stranecky, V.2    Hartmannova, H.3
  • 51
    • 48749112588 scopus 로고    scopus 로고
    • Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
    • Hagenbuch B, Gui C. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 2008;38:778-801.
    • (2008) Xenobiotica , vol.38 , pp. 778-801
    • Hagenbuch, B.1    Gui, C.2
  • 52
    • 25144500468 scopus 로고    scopus 로고
    • Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
    • Mackenzie PI, Bock KW, Burchell B, et al. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet. Genomics 2005;15:677-85.
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 677-685
    • Mackenzie, P.I.1    Bock, K.W.2    Burchell, B.3
  • 53
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol. 2000;40:581-616.
    • (2000) Annu. Rev. Pharmacol. Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 54
    • 0032926354 scopus 로고    scopus 로고
    • Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
    • König J, Rost D, Cui Y, et al. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 1999;29:1156-63.
    • (1999) Hepatology , vol.29 , pp. 1156-1163
    • König, J.1    Rost, D.2    Cui, Y.3
  • 55
    • 0036080426 scopus 로고    scopus 로고
    • Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine
    • Rost D, Mahner S, Sugiyama Y, et al. Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2002;282:G720-6.
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol , vol.282 , pp. G720-G726
    • Rost, D.1    Mahner, S.2    Sugiyama, Y.3
  • 56
    • 0036149075 scopus 로고    scopus 로고
    • Transport activity of human MRP3 expressed in Sf9 cells: Comparative studies with rat MRP3
    • Akita H, Suzuki H, Hirohashi T, et al. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm. Res. 2002;19:34-41.
    • (2002) Pharm. Res , vol.19 , pp. 34-41
    • Akita, H.1    Suzuki, H.2    Hirohashi, T.3
  • 57
    • 0036171510 scopus 로고    scopus 로고
    • Tissue distribution and induction of human multidrug resistant protein 3
    • Scheffer GL, Kool M, de Haas M, et al. Tissue distribution and induction of human multidrug resistant protein 3. Lab. Invest. 2002;82:193-201.
    • (2002) Lab. Invest , vol.82 , pp. 193-201
    • Scheffer, G.L.1    Kool, M.2    de Haas, M.3
  • 58
    • 33846681607 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins 3, 4, and 5
    • Borst P, de Wolf C, van de Wetering K. Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007;453:661-73.
    • (2007) Pflugers Arch , vol.453 , pp. 661-673
    • Borst, P.1    de Wolf, C.2    van de Wetering, K.3
  • 59
    • 33645825217 scopus 로고    scopus 로고
    • Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione
    • Rius M, Hummel-Eisenbeiss J, Hofmann AF, et al. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am. J. Physiol. Gastrointest. Liver Physiol. 2006;290:G640-9.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol , vol.290 , pp. G640-G649
    • Rius, M.1    Hummel-Eisenbeiss, J.2    Hofmann, A.F.3
  • 60
    • 78649656801 scopus 로고    scopus 로고
    • Uptake transporters of the human OATP family: Molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms
    • In: Fromm MF, Kim RB, eds. Heidelberg: Springer
    • König J. Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. In: Fromm MF, Kim RB, eds. Drug Transporters. Handb. Exp. Pharmacol., vol. 201, Heidelberg: Springer, 2011:1-28.
    • (2011) Drug Transporters. Handb. Exp. Pharmacol , vol.201 , pp. 1-28
    • König, J.1
  • 62
  • 63
    • 64549133772 scopus 로고    scopus 로고
    • Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment
    • Lankisch TO, Behrens G, Ehmer U, et al. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment. J. Hepatol. 2009;50:1010-18.
    • (2009) J. Hepatol , vol.50 , pp. 1010-1018
    • Lankisch, T.O.1    Behrens, G.2    Ehmer, U.3
  • 64
    • 7744241812 scopus 로고    scopus 로고
    • Inhibition of human organic anion transporting poly-peptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia
    • Campbell SD, de Morais SM, Xu JJ. Inhibition of human organic anion transporting poly-peptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia. Chem. Biol. Interact. 2004;150:179-87.
    • (2004) Chem. Biol. Interact , vol.150 , pp. 179-187
    • Campbell, S.D.1    de Morais, S.M.2    Xu, J.J.3
  • 65
    • 70349509095 scopus 로고    scopus 로고
    • Interaction of porphyrins with human organic anion transporting polypeptide 1B1
    • Campbell SD, Lau WF, Xu JJ. Interaction of porphyrins with human organic anion transporting polypeptide 1B1. Chem. Biol. Interact. 2009;182:45-51.
    • (2009) Chem. Biol. Interact , vol.182 , pp. 45-51
    • Campbell, S.D.1    Lau, W.F.2    Xu, J.J.3
  • 66
    • 0000552161 scopus 로고
    • Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with report of 12 cases
    • Dubin IN, Johnson FB. Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with report of 12 cases. Medicine (Baltimore) 1954;33:155-79.
    • (1954) Medicine (Baltimore) , vol.33 , pp. 155-179
    • Dubin, I.N.1    Johnson, F.B.2
  • 67
    • 0001414260 scopus 로고
    • Persistent nonhemolytic hyperbilirubinemia associated with lipo-chrome-like pigment in liver cells; report of four cases
    • Sprinz H, Nelson RS. Persistent nonhemolytic hyperbilirubinemia associated with lipo-chrome-like pigment in liver cells; report of four cases. Ann. Intern. Med. 1954;41:952-62.
    • (1954) Ann. Intern. Med , vol.41 , pp. 952-962
    • Sprinz, H.1    Nelson, R.S.2
  • 68
    • 0014859813 scopus 로고
    • Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases
    • Shani M, Seligsohn U, Gilon E, et al. Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases. Quarterly J. Med. 1970;39:549-67.
    • (1970) Quarterly J. Med , vol.39 , pp. 549-567
    • Shani, M.1    Seligsohn, U.2    Gilon, E.3
  • 69
    • 0032545447 scopus 로고    scopus 로고
    • A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome
    • Kajihara S, Hisatomi A, Mizuta T, et al. A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome. Biochem. Biophys. Res. Commun. 1998;253:454-7.
    • (1998) Biochem. Biophys. Res. Commun , vol.253 , pp. 454-457
    • Kajihara, S.1    Hisatomi, A.2    Mizuta, T.3
  • 70
    • 0033361943 scopus 로고    scopus 로고
    • Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
    • Toh S, Wada M, Uchiumi T, et al. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am. J. Hum. Genet. 1999;64:739-46.
    • (1999) Am. J. Hum. Genet , vol.64 , pp. 739-746
    • Toh, S.1    Wada, M.2    Uchiumi, T.3
  • 71
    • 0035813178 scopus 로고    scopus 로고
    • Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
    • Mor-Cohen R, Zivelin A, Rosenberg N, et al. Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J. Biol. Chem. 2001;276:36923-30.
    • (2001) J. Biol. Chem , vol.276 , pp. 36923-36930
    • Mor-Cohen, R.1    Zivelin, A.2    Rosenberg, N.3
  • 72
    • 0032842748 scopus 로고    scopus 로고
    • Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome
    • Tsujii H, König J, Rost D, et al. Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. Gastroenterology 1999;117:653-60.
    • (1999) Gastroenterology , vol.117 , pp. 653-660
    • Tsujii, H.1    König, J.2    Rost, D.3
  • 73
    • 0032526946 scopus 로고    scopus 로고
    • Binary specifications of nonsense codons by splicing and cytoplasmic translation
    • Thermann R, Neu-Yilik G, Deters A, et al. Binary specifications of nonsense codons by splicing and cytoplasmic translation. EMBO J. 1998;17:3484-94.
    • (1998) EMBO J , vol.17 , pp. 3484-3494
    • Thermann, R.1    Neu-Yilik, G.2    Deters, A.3
  • 74
    • 0033652766 scopus 로고    scopus 로고
    • Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
    • Keitel V, Kartenbeck J, Nies AT, et al. Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome. Hepatology 2000;32:1317-28.
    • (2000) Hepatology , vol.32 , pp. 1317-1328
    • Keitel, V.1    Kartenbeck, J.2    Nies, A.T.3
  • 75
    • 0037229540 scopus 로고    scopus 로고
    • A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
    • Keitel V, Nies AT, Brom M, et al. A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). Am. J. Physiol. Gastrointest. Liver Physiol. 2003;284:G165-74.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284 , pp. G165-G174
    • Keitel, V.1    Nies, A.T.2    Brom, M.3
  • 76
    • 0036648878 scopus 로고    scopus 로고
    • Radixin deficiency causes conjugated hyper-bilirubinemia with loss of Mrp2 from bile canalicular membranes
    • Kikuchi S, Hata M, Fukumoto K, et al. Radixin deficiency causes conjugated hyper-bilirubinemia with loss of Mrp2 from bile canalicular membranes. Nature Genet. 2002;31:320-5.
    • (2002) Nature Genet , vol.31 , pp. 320-325
    • Kikuchi, S.1    Hata, M.2    Fukumoto, K.3
  • 77
    • 0242690430 scopus 로고    scopus 로고
    • Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
    • Kojima H, Nies AT, König J, et al. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J. Hepatol. 2003;39:693-702.
    • (2003) J. Hepatol , vol.39 , pp. 693-702
    • Kojima, H.1    Nies, A.T.2    König, J.3
  • 78
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • Beuers U, Bilzer M, Chittattu A, et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001;33:1206-16.
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3
  • 79
    • 0031979439 scopus 로고    scopus 로고
    • Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
    • Roelofsen H, Soroka CJ, Keppler D, et al. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J. Cell Sci. 1998;111:1137-45.
    • (1998) J. Cell Sci , vol.111 , pp. 1137-1145
    • Roelofsen, H.1    Soroka, C.J.2    Keppler, D.3
  • 80
    • 0030963906 scopus 로고    scopus 로고
    • The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
    • Trauner M, Arrese M, Soroka CJ, et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997;113:255-64.
    • (1997) Gastroenterology , vol.113 , pp. 255-264
    • Trauner, M.1    Arrese, M.2    Soroka, C.J.3
  • 81
    • 0036614376 scopus 로고    scopus 로고
    • Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis
    • Mottino AD, Cao J, Veggi LM, et al. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis. Hepatology 2002;35:1409-19.
    • (2002) Hepatology , vol.35 , pp. 1409-1419
    • Mottino, A.D.1    Cao, J.2    Veggi, L.M.3
  • 82
    • 0033019479 scopus 로고    scopus 로고
    • Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis
    • Rost D, Kartenbeck J, Keppler D. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 1999;29:814-21.
    • (1999) Hepatology , vol.29 , pp. 814-821
    • Rost, D.1    Kartenbeck, J.2    Keppler, D.3
  • 83
    • 0034657167 scopus 로고    scopus 로고
    • Electron-microscopic demonstration of multi-drug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide
    • Dombrowski F, Kubitz R, Chittattu A, et al. Electron-microscopic demonstration of multi-drug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem. J. 2000;348:183-8.
    • (2000) Biochem. J , vol.348 , pp. 183-188
    • Dombrowski, F.1    Kubitz, R.2    Chittattu, A.3
  • 84
    • 0030731742 scopus 로고    scopus 로고
    • Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane
    • Kubitz R, D'Urso D, Keppler D, et al. Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 1997;113:1438-42.
    • (1997) Gastroenterology , vol.113 , pp. 1438-1442
    • Kubitz, R.1    D'Urso, D.2    Keppler, D.3
  • 85
    • 83755203890 scopus 로고    scopus 로고
    • The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane
    • Cantore M, Reinehr R, Sommerfeld A, et al. The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane. J. Biol. Chem. 2011; 286:45014-29.
    • (2011) J. Biol. Chem , vol.286 , pp. 45014-45029
    • Cantore, M.1    Reinehr, R.2    Sommerfeld, A.3
  • 86
    • 17744391290 scopus 로고    scopus 로고
    • Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
    • Zollner G, Fickert P, Zenz R, et al. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 2001;33:633-46.
    • (2001) Hepatology , vol.33 , pp. 633-646
    • Zollner, G.1    Fickert, P.2    Zenz, R.3
  • 87
    • 0035668415 scopus 로고    scopus 로고
    • The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function
    • Shoda J, Kano M, Oda K, et al. The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. Am. J. Gastroenterol. 2001;96:3368-78.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 3368-3378
    • Shoda, J.1    Kano, M.2    Oda, K.3
  • 88
    • 24344497926 scopus 로고    scopus 로고
    • Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer
    • Yamada T, Arai T, Nagino M, et al. Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer. Langenbecks Arch. Surg. 2005;390:421-9.
    • (2005) Langenbecks Arch. Surg , vol.390 , pp. 421-429
    • Yamada, T.1    Arai, T.2    Nagino, M.3


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