Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level

Toxicology

Volumn 319, Issue 1, 2014, Pages 10-22

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Asthma rat bioassay; Diisocyanate asthma; Dose response; Neutrophilic inflammation; Risk assessment

Indexed keywords

NITRIC OXIDE; TOLUENE DIISOCYANATE;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ARTICLE; ASTHMA; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; INHALATION; LUNG LAVAGE; MALE; NEUTROPHIL; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RAT; RESPIRATORY SENSITIZATION; RESPIRATORY TRACT ALLERGY; SENSITIZATION; SKIN SENSITIZATION; UPPER RESPIRATORY TRACT;

ASTHMA RAT BIOASSAY; DIISOCYANATE ASTHMA; DOSE-RESPONSE; NEUTROPHILIC INFLAMMATION; RISK ASSESSMENT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HAPTENS; HUMANS; IRRITANTS; MALE; OCCUPATIONAL EXPOSURE; RATS; RATS, INBRED BN; RESPIRATORY HYPERSENSITIVITY; TOLUENE 2,4-DIISOCYANATE;

EID: 84896039326     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.02.006     Document Type: Article

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