Brown Norway rat asthma model of diphenylmethane-4,4′-diisocyanate (MDI): Analysis of the elicitation dose-response relationship

Toxicological Sciences

Volumn 104, Issue 2, 2008, Pages 320-331

  Pauluhn, Jürgen ^a  

^a Institute of Toxicology   (Germany)

Author keywords

Delayed responses; Diisocyanate asthma; Diphenylmethane diisocyanate; Dose metric; Dose response; Lung function; MDI; Nutrophilic inflammation; Penh; Respiratory allergy

Indexed keywords

DIPHENYLMETHANE 4,4' DIISOCYANATE;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; CLINICAL PROTOCOL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; HYPERSENSITIVITY REACTION; INHALATION; LUNG LAVAGE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; RESPIRATORY TRACT INFLAMMATION; SKIN SENSITIZATION;

ADMINISTRATION, INHALATION; ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERSENSITIVITY; ISOCYANATES; LEUKOCYTE COUNT; LUNG; MALE; NEUTROPHILS; RATS; RATS, INBRED BN; RESPIRATORY FUNCTION TESTS; SKIN; SKIN ABSORPTION;

RATTUS; RATTUS NORVEGICUS;

EID: 47849104069     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn098     Document Type: Article

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