Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology

Regulatory Toxicology and Pharmacology

Volumn 61, Issue 3, 2011, Pages 351-364

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Aerosol; Diisocyanates; Disposition; Irritation; Lung overload; Oxidative stress; Particle clearance; Pulmonary toxicity; Repeated inhalation exposure

Indexed keywords

DIPHENYLMETHANE 4,4' DIISOCYANATE; NUCLEOPHILE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CHRONIC INFLAMMATION; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSIMETRY; FEMALE; HISTOPATHOLOGY; ISOMER; LETHALITY; LONG TERM EXPOSURE; LUNG INJURY; LUNG LAVAGE; MALE; MATHEMATICAL COMPUTING; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IRRITANTS; ISOCYANATES; ISOMERISM; LUNG; MALE; PHOSPHOLIPIDS; POLYURETHANES; RATS; RATS, WISTAR; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC;

RATTUS;

EID: 80855144167     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.09.007     Document Type: Article

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