Brown Norway rat asthma model of diphenylmethane 4,4′-diisocyanate

Inhalation Toxicology

Volumn 17, Issue 13, 2005, Pages 729-739

  Pauluhn, Jürgen ^a,b  

^a BAYER PHARMA AG   (Germany)

^b Institute of Toxicology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYLMETHANE 4,4' DIISOCYANATE; IMMUNOGLOBULIN E; IRRITANT AGENT; LACTATE DEHYDROGENASE;

AEROSOL; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRONCHUS; CELL INFILTRATION; CELL STRUCTURE; CONTROLLED STUDY; FIBROSIS; HISTOPATHOLOGY; HYPERTROPHY; INFLAMMATION; INHALATION; LUNG ALVEOLUS; LUNG LAVAGE; LUNG WEIGHT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN; VASCULAR DISEASE;

ADMINISTRATION, INHALATION; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE; DISEASE MODELS, ANIMAL; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INFLAMMATION; IRRITANTS; ISOCYANATES; LUNG; RATS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 27144503716     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370500224631     Document Type: Article

References (38)

1. Benayoun, L., Druilhe, A., Dombret, M. C., Aubier, M., and Pretolani, M. 2003. Airway structural alterations selectively associated with severe asthma. Am. J. Respir. Crit. Care Med. 167:1360-1368.
2. Blyth, D. I., Pedrick, M. S., Savage, T. J., Hessel, E. M., and Fattah, D. 1996. Lung inflammation and epithelial changes in a murine model of atopic asthma. Am. J. respir. Cell. Mol. Biol. 14:425-428.
3. Chan-Yeung, M., and Malo, J. L. 1994. Aetiological agents in occupational asthma. Eur. Respir. J. 7:346-371.
4. European Community. 1986. Directive 86/609/EEC. Guideline of the Council dated November 24, 1986 on the reconciliation of legal and administrative regulations of the member countries for the protection of animals used for studies and other scientific purposes. J. Eur. Commun. Legal Specifications L358, 29:1-28.
5. Fabbri, L. M., Boschetto, P., Zocca, E., Milani, G., Pivirotto, F., Plebani, M., Burlina, A., Licata, B., and Mapp, C. E. 1987. Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am. Rev. Respir. Dis. 136:36-42.
6. Gad, S. C., and Weil, C. S. 1982. Statistics for toxicologists. In Principles and methods of toxicology, ed. A. W. Hayes, p. 280. New York: Raven Press.
7. Haczku, A., Moqbel, R., Elwood, W., Sun, J., Bay, A. B., Barnes, P. J., and Chung, K. F. 1994. Effect of prolonged repeated exposure to ovalbumin in sensitized Brown Norway rats. Am. J. Respir. Crit. Care Med. 150:23-27.
8. Hantos, Z., and Brusasco, V. 2002. Assessment of respiratory mechanics in small animals: The simpler the better? J. Appl. Physiol. 93:1196-1197.
9. Holgate, S. T., Lackie, P., Wilson, S., Roche, W., and Davies, D. 2000. Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma. Am. J. Respir. Crit. Care Med. 162/2:8113-S117
10. Jatakanon, A., Uasuf, C., Maziak, W., Lim, S., Chung, K. F., and Barnes, P. J. 1999. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med. 160:1532-1539.
11. Johnson, V. J., Matheson, J. M., and Luster, M. I. 2004. Animal models for diisocyanate asthma: Answers for lingering questions. Curr. Opin. Allergy Clin. Immunol. 4:105-110.
12. Jung, K., and Park, H. 1999. Evidence of neutrophils activation in occupational asthma. Respirology 4:303-306.
13. Karol, M. H., and Thorne, P. S. 1988. Pulmonary hypersensitivity and hyperreactivity: Implications for assessing allergic responses. In Toxicology of the lung, eds. D. E. Gardner, J. D. Crapo, and E. J. Massaro, pp. 427-448. New York: Raven Press.
14. Kips, J. C., Anderson, G. P., Fredberg, J. J., Herz, U., Inman, M. D., Jordana, M., Kemeny, D. M., Lötvall, J., Pauwels, R. A., Plopper, C. G., Schmidt, D., Sterk, P. J., van Oosterhout, A. J. M., Vargaftig, B. B., and Chung, K. F. 2003. Murine models of asthma. Eur. Respir. J. 22:374-382.
15. Kumar, R. K., Herbert, C., and Foster, P. S. 2004. Expression of growth factors by airway epithelial cells in a model of chronic asthma: Regulation and relationship to subepithelial fibrosis. Clin. Exp. Allergy 34:567-575.
16. Leigh, R., Ellis, R., Wattie, J., Southam, D. S., De Hoogh, M., Gauldie, J., O'Byrne, P. M., and Inman, M. D. 2002. Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am. J. Respir. Cell Mol. Biol. 27:526-535.
17. Lemiere, C., Romeo, P., Chaboillez, S., Tremblay, C., and Malo, J. L. 2002. Airway inflammation and functional changes after exposure to different concentrations of isocyanates. J. Allergy Clin. Immunol. 110:641-646.
18. Lemiere, C., Pelissier, S., Tremblay, C., Chaboillez, S., Thivierge, M., Stankova, J., and Rola-Pleszczynski, M. 2004. Leukotrienes and isocyanate-induced astha: A pilot study. Clin. Exp. Allergy 34:1684-1689.
19. Maestrelli, P., Calcagni, P. G., Saetta, M., Di Stefano, A., Hosselet, J. J., Santonastaso, A., Fabbri, L. M., and Mapp, C. E. 1994. Sputum eosinophilia after asthmatic responses induced by isocyanates in sensitized subjects. Clin. Exp. Allergy 24:29-34.
20. Maghni, K., Lemiere, C., Ghezzo, H., Yuquan, W., and Malo, J. L. 2004. Airway inflammation after cessation of exposure to agents causing occupational asthma. Am. J. Respir. Crit. Care Med. 169:367-372.
21. Mitzner, W., Tankersley, C., Lundblad, L. K., Adler, A., Irvin, C. G., and Bates, J. 2003. Interpreting Penh in mice. J. Appl. Physiol. 94:828-832.
22. Mitzner, W., and Tankersley, C. 1998. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 158:340-341.
23. Moir, L. M., Leung, S. Y., Eynott, P. R., McVicker, C. G., Ward, J. P., Chung, K. F., and Hirst, S. J. 2002. Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats. Am. J. Physiol. Lung Cell Mol. Physiol. 284:L148-159.
24. Palmans, E., Kips, J. C., and Pauwels, R. A. 2000. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am. J. Respir. Crit. Care Med. 161:627-635.
25. Palmans, E., Pauwels, R. A., and Kips, J. C. 2002. Repeated allergen exposure changes collagen composition in airways of sensitized Brown Norway rats. Eur. Respir. J. 20:280-285.
26. Pauluhn, J. 2000. Acute inhalation toxicity of polymeric diphenylmethane-4,4′-diisocyanate (MDI) in rats: Time course of changes in bronchoalveolar lavage. Arch. Toxicol. 74:257-269.
27. Pauluhn, J. 2003. Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: Analysis of dose-response following topical induction and time course following repeated inhalation challenge. Toxicology 194:1-17.
28. Pauluhn, J. 2004. Comparative analysis of pulmonary irritation by measurements of Penh and protein in bronchoalveolar lavage fluid in Brown Norway rats and Wistar rats exposed to irritant aerosols. Inhal. Toxicol. 16:159-175.
29. Pauluhn, J., and Eben, A. 1991. Validation of a non-invasive technique to assess immediate or delayed onset of airway hypersensitivity in guinea-pigs. J. Appl. Toxicol. 11:423-431.
30. Pauluhn, J., and Mohr, U. 2005. Experimental approaches to evaluate respiratory allergy in animal models. Exp. Toxicol. Pathol. 56:203-234.
31. Pauluhn, J., Woolhiser, M. R., and Bloemen, L. 2005. Repeated inhalation challenge with diphenylmethane-4,4′-diisocyanate in brown Norway rats leads to a time-related increase of neutrophils in bronchoalveolar lavage after topical induction. Inhal. Toxicol. 17:67-78.
32. Peták, F., Habre, W., Donati, Y. R., Hantos, Z., and Barazzone-Argiroffo, C. 2001. Hyperoxia-induced changes in mouse lung mechanics: Forced oscillations vs. barometric plethysmography. J. Appl. Physiol 90:2221-2230.
33. Sun, Y.-C., and Hon, W. C. 2004. Viewpoint: Do neutrophils actively participate in airway inflammation and remodeling in asthma? Chin. Med. J. 117:1739-1742.
34. Tillie-Leblond, I., Gosset, P., and Tonnel, A. B. 2005. Inflammatory events in severe acute asthma. Allergy 60:23-29.
35. Tomkinson, A., Cieslewicz, G., Duez, C., Larson, C. D., Lee, J. J., and Gelfand, E. W. 2001. Tempral association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice. Am. J. Respir. Crit. Care Med. 163:721-730.
36. Warbrick, E. V., Dearman, R. J., and Kimber, I. 2002. IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: Comparison of inhalation and topical exposure. Toxicology 172:157-168.
37. Xisto, D. G., Farias, L. L., Ferreira, H. C., Picanco, M. R., Amitrano, D., Lapa, E., Silva, J. R., Negr, E. M., Mauad, T., Carnielli, D., Silva, L. F., Capelozzi, V. L., Faffe, D. S., Zin, W. A., and Rocco, P. R. 2005. Lung parenchyma remodeling in a murine model of chronic allergic inflammation. Am. J. Respir. Crit. Care Med. 171:829-837.
38. Zhang, X. D., Fedan, J. S., Lewis, D. M., and Siegel, P. D. 2004. Asthma-like biphasic airway responses in Brown Norway rats sensitized by dermal exposure to dry trimellitic anhydride powder. J. Allergy Clin. Immunol. 113:320-326.