Multiple challenges in a mouse model of chemical-induced asthma lead to tolerance: Ventilatory and inflammatory responses are blunted, immunologic humoral responses are not

Toxicology

Volumn 257, Issue 3, 2009, Pages 144-152

  Vanoirbeek, Jeroen A J ^a   De Vooght, Vanessa ^a   Nemery, Benoit ^a   Hoet, Peter H M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

IFN ; IgE; IL 4; Murine model; Occupational asthma; Tolerance; Toluene 2,4 diisocyanate

Indexed keywords

CD19 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERLEUKIN 4; METHACHOLINE; TOLUENE DIISOCYANATE;

AIRWAY; AIRWAY DYNAMICS; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CERVICAL LYMPH NODE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATION; LUNG LAVAGE; LYMPHATIC DRAINAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY FUNCTION;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODY FORMATION; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTOR AGENTS; CYTOKINES; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFLAMMATION; LUNG; LYMPH NODES; LYMPHOCYTES; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; RESPIRATORY MECHANICS;

MURINAE; MUS;

EID: 60249085286     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.12.020     Document Type: Article

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