Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology following dermal exposure of male rats to TDI

Toxicology Letters

Volumn 199, Issue 3, 2010, Pages 364-371

  Hoffmann, H D ^a   Leibold, E ^a   Ehnes, C ^a   Fabian, E ^a   Landsiedel, R ^a   Gamer, A ^a   Poole, A ^b  

^a BASF SE   (Germany)

^b DOW EUROPE GMBH   (Switzerland)

Author keywords

2,4 Toluene diisocyanate; 2,6 Toluene diisocyanate; 4,4 methylene diphenyl diisocyanate; Dermal uptake; Skin pathology

Indexed keywords

METHYLENE DIPHENYL DIISOCYANATE; POLYURETHAN; TOLUENE DIISOCYANTE; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISTRIBUTION VOLUME; ENVIRONMENTAL EXPOSURE; EXCRETION; HISTOPATHOLOGY; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS;

ANIMALS; CARBON RADIOISOTOPES; ISOCYANATES; MALE; RATS; RATS, WISTAR; SKIN; TOLUENE 2,4-DIISOCYANATE;

RATTUS; ZEA MAYS;

EID: 78650512708     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.09.021     Document Type: Article

References (29)

1. Allport D.C., Gilbert D.S., Outterside S.M. Part: MDI and TDI usage. MDI and TDI; Safety, Health and Environment 2003, Wiley & Sons Ltd., pp. 1-6.
2. Allport D.C., Gilbert D.S., Outterside S.M. Part: Handling MDI and TDI. MDI and TDI; Safety, Health and Environment 2003, Wiley & Sons Ltd., p. 32.
3. Allport D.C., Gilbert D.S., Outterside S.M. Part: Supporting Sciences. MDI and TDI; Safety, Health and Environment 2003, Wiley & Sons Ltd., p. 285.
4. Allport D.C., Gilbert D.S., Outterside S.M. Part: Health, in MDI and TDI. Safety, Health and Environment 2003, Wiley & Sons Ltd., p. 188.
5. Allport D.C., Gilbert D.S., Outterside S.M. Part: Health. MDI and TDI; Safety, Health and Environment 2003, Wiley & Sons Ltd., p. 170.
6. Allport D.C., Gilbert D.S., Outterside S.M. Part: Health. MDI and TDI; Safety, Health and Environment 2003, Wiley & Sons Ltd., p. 164.
7. Allport D.C., Gilbert D.S., Outterside S.M. Parts: Health and Supporting Sciences. MDI and TDI; Safety, Health and Environment; 2003, Wiley & Sons Ltd., p. 189 and 291.
8. Bertrand J.-P., Wantz J.M., Heintz P., Zitter M. Pathologie liée á l'utilisation des isocyanates dans les mines de charbon de Lorraine. Arch. Mal. Prof. 1984, 45:3-9.
9. Botham P.A., Hext P.M., Rattray N.J., Walsh S.T., Woodcock D.R. Sensitisation of guinea pigs by inhalation exposure to low molecular weight chemicals. Toxicol. Lett. 1988, 41:159-173.
10. Brown W.E. The chemistry and biochemistry of isocyanates: an overview. Curr. Top. Pulm. Pharmacol. Toxicol. 1986, 1:200-225.
11. Draize J.H. Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics 1959, The Association of Food and Drug officials of the United States, Austin, Texas.
12. Duprat P., Gradisk D., Marignac B. Irritating and allergizing power of two isocyanates; toluene diisocyanate (tdi). diphenylmethane diisocyanate (MDI). Eur. J. Toxicol. 1976, 9:41-53.
13. Henschler D., Assmann W., Meyer K.O. Zur Toxikologie der Toluylen diisocyanate. Arch. Toxikol. 1962, 19:364-387.
14. Yeh H.-J., Lin W.-C., Shih T.-S., Tsai P.-J., Wang S.-T., Chang H.-Y. Urinary excretion of toluene diisocyanates in rats following dermal exposure. J. Appl. Toxicol. 2008, 28:189-195.
15. Karlsson D., Delane M., Skarping G. Determination of complex mixtures of airborne isocyanates and amines. Part 5 determination of low molecular weight aliphatic isocyanates as dibutylamine derivatives. Analyst 1998, 123:1507-1512.
16. Karol M.H. Concentration dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicol. Appl. Pharmacol. 1983, 68:229-241.
17. 14C during and following inhalation exposure to radioactive toluene diisocynate. Toxicol. and Appl. Pharmacol. 1989, 100:280-292.
18. 14C-labelled toluene diisocyanate (TDI) in rats. Arch. Toxicol. 1994, 68:434-443.
19. Mráz J., Bousková S. 2,4 toluene diisocyanate and hexamethylene diisocyanate adducts with blood proteins: assessment of reactivity of amino acid residues in vitro. Chem. Biol. Interact. 1999, 117:173-186.
20. Nakashima K., Takeshita T., Morimoto K. Review of the occupational exposure to isocyanates: mechanism of action. Environ. Health Perspect. Med. 2010, 7:1-6.
21. Persson P., Dalene M., Skarping G., Adamsson M., Hagmar L. Biological monitoring of occupational exposure to toluene diisocyante: measurement of toluene diamine in hydrolyzed urine and plasma by gas chromatography-mass spectrometry. Br. J. Ind. Med. 1993, 50:1111-1118.
22. Rattray N.J., Botham P.A., Hext P.M., Woodcock D.R., Fielding I., Dearman R.J., Kimber I. Induction of respiratory hypersensitivity to diphenlylmethane-4.4′-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology 1994, 84:15-30.
23. Sabbioni G., Hartley R., Henschler D., Höllrigl-Rosta A., Koerber R., Schneider S. Isocyanate-specific hemoglobin adduct in rats exposed to 4,4′-methylene diphenyl diisocyanate. Chem. Res. Toxicol. 2000, 13:82-89.
24. Sabbioni G., Wesp H., Lewalter J., Rumler Determination of isocyanate biomarkers in construction site workers. Biomarkers 2007, 12:468-483.
25. Sepai O., Schütze D., Heinrich U., Hoymann H.G., Henschler D., Sabbioni G. Hemoglobine adducts and urine metabolites of 4,4′ methylene dianiline after 4,4′ methylene diphenyl diisocyanate exposure of rats. Chem. Biol. Interact. 1995, 97:185-198.
26. Skarping G., Dalene M., Littorin M. 4,4′-methylene dianiline in hydrolyzed serum and urine from a worker exposed to thermal degradation products of methylene diphenyl diisocyanate elastomers. Int. Arch. Occup. Environ. Health 1995, 67:73-77.
27. Spanne M., Tinnerberg M., Dalene M., Skarping G. Determination of complex mixtures of airborne isocyanates and amines. Part 1. Liquid chromatography with ultraviolet detection of monomeric and polymeric isocyanates as their dibutylamine derivatives. Analyst 1996, 1095-1099.
28. Tinnerberg H., Spanne M., Delane M., Skarping G. Determination of complex mixtures of airborne isocyanates and amines. Part 3. Methylene diphenyl diisocyanate. (MDI), methylene diphenylamino isocyanate and methylene diphenyl diamine and structural analogues after thermal degradation of polyurethane. Analyst 1997, 122:275-278.
29. Vock E.H., Lutz W.K. Distribution and DNA adduct formation of radiolabelled 4,4′-methylene diphenyl diisocyanate. (MDI) after topical treatment. Toxicol. Lett. 1997, 92:93-100.