Brown Norway rat asthma model of diphenylmethane-4,4′-diisocyanate (MDI): Determination of the elicitation threshold concentration of after inhalation sensitization

Toxicology

Volumn 281, Issue 1-3, 2011, Pages 15-24

  Pauluhn, Jürgen ^a   Poole, Alan ^b  

^a BAYER PHARMA AG   (Germany)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

Delayed responses; Diisocyanate asthma; Dose response; Lung function; Neutrophilic inflammation; Penh; Respiratory allergy; Risk assessment

Indexed keywords

DIPHENYLMETHANE 4,4' DIISOCYANATE;

AEROSOL; ALLERGIC PNEUMONITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; ATMOSPHERE; BREATHING PATTERN; BROWN NORWAY RAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; LUNG LAVAGE; LUNG WEIGHT; LYMPH NODE; MALE; NONHUMAN; ORGAN WEIGHT; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; RESPIRATORY TRACT ALLERGY; SENSITIZATION; SKIN SENSITIZATION;

ADMINISTRATION, INHALATION; AEROSOLS; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; ISOCYANATES; LUNG; MALE; MAXIMUM ALLOWABLE CONCENTRATION; RATS; RATS, INBRED BN;

RATTUS; RATTUS NORVEGICUS;

EID: 79851515852     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2011.01.005     Document Type: Article

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