Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer pc-3 cells by reducing matrix metalloproteinases expression

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Chen, Pin Shern ^a   Shih, Yuan Wei ^b   Huang, Hsiang Ching ^a   Cheng, Hsing Wen ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD147 ANTIGEN; DIOSGENIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRILYSIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SAPONIN; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VASCULOTROPIN; BSG PROTEIN, HUMAN; VASCULOTROPIN A;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MIGRATION INHIBITION; PROSTATE CANCER; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY; CELL MOTION; GENETICS; IMMUNOBLOTTING; METABOLISM; POLYMERASE CHAIN REACTION; PROSTATE TUMOR; TUMOR CELL LINE;

TRIGONELLA FOENUM-GRAECUM;

ANTIGENS, CD147; CELL LINE, TUMOR; CELL MOVEMENT; DIOSGENIN; HUMANS; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79956370706     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020164     Document Type: Article

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