-
1
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah,N.G. et al. (2012) The biology and therapeutic targeting of the proprotein convertases. Nat. Rev. Drug Discov., 11, 367-383.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
-
2
-
-
84869191516
-
Role of proprotein convertases in prostate cancer progression
-
Couture,F. et al. (2012) Role of proprotein convertases in prostate cancer progression. Neoplasia, 14, 1032-1042.
-
(2012)
Neoplasia
, vol.14
, pp. 1032-1042
-
-
Couture, F.1
-
3
-
-
84877993047
-
Inhibition of tumor cells proliferation and migration by the flavonoid furin inhibitor isolated from Oroxylum indicum
-
Lalou,C. et al. (2013) Inhibition of tumor cells proliferation and migration by the flavonoid furin inhibitor isolated from Oroxylum indicum. Curr. Med. Chem., 20, 583-591.
-
(2013)
Curr. Med. Chem.
, vol.20
, pp. 583-591
-
-
Lalou, C.1
-
4
-
-
27644521904
-
Proprotein convertases: "master switches" in the regulation of tumor growth and progression
-
Bassi,D.E. et al. (2005) Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol. Carcinog., 44, 151-161.
-
(2005)
Mol. Carcinog.
, vol.44
, pp. 151-161
-
-
Bassi, D.E.1
-
5
-
-
0036083664
-
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy
-
Khatib,A.M. et al. (2002) Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am. J. Pathol., 160, 1921-1935.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1921-1935
-
-
Khatib, A.M.1
-
6
-
-
77955623211
-
Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain
-
Basak,A. et al. (2010) Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain. Curr. Med. Chem., 17, 2214-2221.
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 2214-2221
-
-
Basak, A.1
-
7
-
-
0035903230
-
Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions
-
Khatib,A.M. et al. (2001) Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J. Biol. Chem., 276, 30686-30693.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30686-30693
-
-
Khatib, A.M.1
-
8
-
-
38149024974
-
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells
-
Scamuffa,N. et al. (2008) Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. J. Clin. Invest., 118, 352-363.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 352-363
-
-
Scamuffa, N.1
-
9
-
-
77956314907
-
Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53 CDKN2A and N-Ras genes
-
Lalou,C. et al. (2010) Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53, CDKN2A and N-Ras genes. PLoS One, 5, e9992.
-
(2010)
PLoS One
, vol.5
-
-
Lalou, C.1
-
10
-
-
42949119406
-
Inhibitory feature of the proprotein convertases prosegments
-
Bontemps,Y. et al. (2008) Inhibitory feature of the proprotein convertases prosegments. Med. Chem., 4, 116-120.
-
(2008)
Med. Chem.
, vol.4
, pp. 116-120
-
-
Bontemps, Y.1
-
11
-
-
0033607676
-
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases In vitro and ex vivo assessment of their efficacy and selectivity
-
Zhong,M. et al. (1999) The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. J. Biol. Chem., 274, 33913-33920.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33913-33920
-
-
Zhong, M.1
-
12
-
-
0035815635
-
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding The proand transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
-
Benjannet,S. et al. (2001) Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The proand transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem., 276, 10879-10887.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
-
13
-
-
77951248592
-
A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A B and proVEGF-C
-
Basak,A. et al. (2009) A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. PLoS One, 4, e7700.
-
(2009)
PLoS One
, vol.4
-
-
Basak, A.1
-
14
-
-
34548019745
-
Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases
-
Bontemps,Y. et al. (2007) Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases. Med. Res. Rev., 27, 631-648.
-
(2007)
Med. Res. Rev.
, vol.27
, pp. 631-648
-
-
Bontemps, Y.1
-
15
-
-
27144488288
-
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases
-
Siegfried,G. et al. (2005) Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene, 24, 6925-6935.
-
(2005)
Oncogene
, vol.24
, pp. 6925-6935
-
-
Siegfried, G.1
-
16
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger,J. (2000) Cell signaling by receptor tyrosine kinases. Cell, 103, 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
17
-
-
44149115749
-
The potential role of Akt phosphorylation in human cancers
-
Cicenas,J. (2008) The potential role of Akt phosphorylation in human cancers. Int. J. Biol. Markers, 23, 1-9.
-
(2008)
Int. J. Biol. Markers
, vol.23
, pp. 1-9
-
-
Cicenas, J.1
-
18
-
-
24944528243
-
AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma
-
Kim,C.S. et al. (2005) AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma. Endocrinology, 146, 4456-4463.
-
(2005)
Endocrinology
, vol.146
, pp. 4456-4463
-
-
Kim, C.S.1
-
19
-
-
0037379743
-
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-Ainduced functions and tumorigenicity
-
Siegfried,G. et al. (2003) The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-Ainduced functions and tumorigenicity. Cancer Res., 63, 1458-1463.
-
(2003)
Cancer Res
, vol.63
, pp. 1458-1463
-
-
Siegfried, G.1
-
20
-
-
35148878210
-
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1
-
Lapierre,M. et al. (2007) Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1. Cancer Res., 67, 9030-9034.
-
(2007)
Cancer Res
, vol.67
, pp. 9030-9034
-
-
Lapierre, M.1
-
21
-
-
34447118236
-
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer
-
Page,R.E. et al. (2007) Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell. Oncol., 29, 289-299.
-
(2007)
Cell. Oncol.
, vol.29
, pp. 289-299
-
-
Page, R.E.1
-
22
-
-
45849095753
-
MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice
-
De Vos,L. et al. (2008) MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. Int. J. Oncol., 32, 1073-1083.
-
(2008)
Int. J. Oncol.
, vol.32
, pp. 1073-1083
-
-
De Vos, L.1
-
23
-
-
84857782004
-
Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/ autologous tumor cell" vaccine (FANG) in advanced cancer
-
Senzer,N. et al. (2012) Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/ autologous tumor cell" vaccine (FANG) in advanced cancer. Mol. Ther., 20, 679-686.
-
(2012)
Mol. Ther.
, vol.20
, pp. 679-686
-
-
Senzer, N.1
-
24
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker,N.A. et al. (2002) Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res., 62, 3729-3735.
-
(2002)
Cancer Res
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
-
25
-
-
0037093274
-
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
-
Nakanishi,K. et al. (2002) Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res., 62, 2971-2975.
-
(2002)
Cancer Res
, vol.62
, pp. 2971-2975
-
-
Nakanishi, K.1
-
26
-
-
0033604523
-
The IGF-I receptor in cancer research
-
Baserga,R. (1999) The IGF-I receptor in cancer research. Exp. Cell Res., 253, 1-6.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 1-6
-
-
Baserga, R.1
-
27
-
-
84859890474
-
Autocrine PDGF stimulation in malignancies
-
Heldin,C.H. (2012) Autocrine PDGF stimulation in malignancies. Ups. J. Med. Sci., 117, 83-91.
-
(2012)
Ups. J. Med. Sci.
, vol.117
, pp. 83-91
-
-
Heldin, C.H.1
-
28
-
-
20144371230
-
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase Furin
-
Lopez de Cicco,R. et al. (2005) Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase Furin. Cancer Res., 65, 4162-4171.
-
(2005)
Cancer Res
, vol.65
, pp. 4162-4171
-
-
Lopez de Cicco, R.1
-
29
-
-
2442664240
-
Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model
-
Nejjari,M. et al. (2004) Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model. Am. J. Pathol., 164, 1925-1933.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1925-1933
-
-
Nejjari, M.1
-
30
-
-
33646185371
-
RNAi-mediated gene silencing in nonhuman primates
-
Zimmermann,T.S. et al. (2006) RNAi-mediated gene silencing in nonhuman primates. Nature, 441, 111-114.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
|