Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: Importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 30686-30693

  Khatib, Abdel Majid ^a,d   Siegfried, Géraldine ^a   Prat, Annik ^a   Luis, José ^b   Chrétien, Michel ^c   Metrakos, Peter ^d   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b AIX MARSEILLE UNIVERSITY   (France)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; HORMONES; IMMUNOLOGY; TUMORS;

INOCULATION;

ENZYME INHIBITION;

ALPHA 1 ANTITRYPSIN; ALPHA1 ANTITRYPSIN PORTLAND; CD31 ANTIGEN; CONVERTASE SKI 1; DNA; ENZYME; FURIN; HORMONE PRECURSOR; INSULIN RELATED SUBSTRATE 1; KEXIN; PACE4 PROTEIN; PC7 PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROINSULIN LIKE GROWTH FACTOR 1 RECEPTOR; PROPROTEIN CONVERTASE; PROTEIN; PROTROPHIC FACTOR; SKI 1 PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SUBTILISIN; THYMIDINE; TISSUE PLASMINOGEN ACTIVATOR; TYROSINE; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; PHOSPHOPROTEIN; PROTEIN PRECURSOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BETA CHAIN; CANCER CELL CULTURE; CANCER GENETICS; CANCER INVASION; CARCINOGENICITY; CARCINOMA CELL; COLON CARCINOMA; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE THERAPY; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUDE MOUSE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME; ANIMAL; CELL STRAIN HT29; COLON TUMOR; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; VASCULARIZATION;

ANIMALIA; MUS MUSCULUS;

ALPHA 1-ANTITRYPSIN; ANIMALS; APOPTOSIS; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; NEOPLASM INVASIVENESS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PRECURSORS; RECEPTOR, IGF TYPE 1; TYROSINE;

EID: 0035903230     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101725200     Document Type: Article

References (74)

1. Seidah, N. G., and Chrétien, M. (1997) Curr. Opin. Biotechnol. 8, 602-607
2. Nakayama, K. (1997) Biochem. J. 32, 625-635
3. Zhou, A., Webb, G., Zhu, X., and Steiner, D. F. (1999) J. Biol. Chem. 274, 20745-20748
4. Seidah, N. G., and Chrétien, M. (1999) Brain Res. 848, 45-62
5. Lissitzky, J. C., Luis, J., Munzer, J. S., Benjannet, S., Parat, F., Marvaldi, J., Chrétien, M., and Seidah, N. G. (2000) Biochem. J. 346, 133-138
6. Santavicca, M., Noel, A., Anglikerm, H., Stoll, I., Segain, J. P., Anglard, P., Chrétien, M., Seidah, N. G., and Basset, P. (1996) Biochem. J. 315, 953-958
7. Yana, I., and Weiss, S. J. (2000) Mol. Biol. Cell 11, 2387-2401
8. Dubois, C. M., Laprise, M. H., Blanchette, F., Gentry, L. E., and Leduc, R. (1995) J. Biol. Chem. 270, 10618-10624
9. Dubois, C. M., Blanchette, F., Laprise, M. H., Leduc, R., Grondin, F., and Seidah, N. G. (2001) Am. J. Pathol. 158, 305-316
10. Duguay, S. J., Milewski, W. M., Young, B. D., Nakayama, K., and Steiner, D. F. (1997) J. Biol. Chem. 272, 6663-6670
11. Duguay, S. J., Jin, Y., Stein, J., Duguay, A. N., Gardner, P., and Steiner, D. F. (1998) J. Biol. Chem. 273, 18443-18451
12. Duguay, S. J. (1999) Horm. Metab. Res. 31, 43-49
13. Alarcon, C., Cheatham, B., Lincoln, B., Kahn, C. R., Siddle, K., and Rhodes, C. J. (1994) Biochem. J. 301, 257-265
14. Campan, M., Yoshizumi, M., Seidah, N. G., Lee, M. E., Bianchi, C., and Haber, E. (1996) Biochemistry 35, 3797-3802
15. Anderson, E. D., Thomas, L., Hayflick, J. S., and Thomas, G. (1993) J. Biol. Chem. 268, 24887-24891
16. Benjannet, S., Savaria, D., Laslop, A., Munzer, J. C., Chrétien, M., Marcinkiewicz, M., and Seidah, N. G. (1997) J. Biol. Chem. 272, 26210-26218
17. Jean, F., Stella, K., Thomas, L., Liu, G., Xiang, Y., Reason, A. J., and Thomas, G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7293-7298
18. Zhong, M., Munzer, J. S., Basak, A., Benjannet, S., Mowla, S. J., Decroly, E., Chrétien, M., and Seidah, N. G. (1999) J. Biol. Chem. 274, 33913-33920
19. Lopez-Perez, E., Seidah, N. G., and Checler, F. J. (1999) Neurochemistry 73, 2056-2062
20. Abrami, L., Fivaz, M., Decroly, E., Seidah, N. G., Jean, F., Thomas, G., Leppla, S. H., Buckley, J. T., and van der Goot, F. G. (1998) J. Biol. Chem. 273, 32656-32661
21. Logeat, F., Bessia, C., Brou, C., LeBail, O., Jarriault, S., Seidah, N. G., and Israel, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8108-8112
22. Cui, Y., Jean, F., Thomas, G., and Christian, J. L. (1998) EMBO J. 17, 4735-4743
23. Vollenweider, F., Benjannet, S., Decroly, E., Savaria, D., Lazure, C., Thomas, G., Chretien, M., and Seidah, N. G. (1996) Biochem. J. 314, 521-532
24. Mbikay, M., Seidah, N. G., and Chrétien, M. (1993) Ann. N. Y. Acad. Sci. 680, 13-19
25. Chrétien, M., Mbikay, M., Gaspar, L., and Seidah, N. G. (1995) Proc. Assoc. Am. Physicians 107, 47-66
26. Vieau, D., Seidah, N. G., Mbikay, M., Chrétien, M., and Bertagna, X. (1994) J. Clin. Endocrinol. Metab. 79, 1503-1506
27. Liu, B., Amizuka, N., Goltzman, D., and Rabbani, S. A. (1995) Int. J. Cancer 63, 276-281
28. Mbikay, M., Sirois, F., Yao, J., Seidah, N. G., and Chrétien, M. (1997) Br. J. Cancer 75, 1509-1514
29. Cheng, M., Watson, P. H., Paterson, J. A., Seidah, N. G., Chrétien, M., and Shiu, R. P. C (1997) Int. J. Cancer 71, 966-971
30. Cheng, M., Xu, N., Iwasiow, B., Seidah, N. G., Chrétien, and Shiu, R. P. C. (2001) J. Mol. Endocrinol. 26, 95-105
31. Kayo, T., Sawada, Y., Suzuki, Y., Suda, M., Tanaka, S., Konda, Y., Miyazaki, J., and Takeuchi, T. (1996) J. Biol. Chem. 271, 10731-10737
32. Konda, Y., Yokota, H., Kayo, T., Horiuchi, T., Sugiyama, N., Tanaka, S., Takata, K., and Takeuchi, T. (1997) J. Clin. Invest. 99, 1842-1851
33. Bassi, D. E., Mahloogi, H., and Klein-Szanto, A. J. (2000) Mol. Carcinog. 28, 63-69
34. Kayo, T., Sawada, Y., Suda, M., Konda, Y., Izumi, T., Tanaka, S., Shibata, H., and Takeuchi, T. (1997) Diabetes 46, 1296-1304
35. Baserga, R. (1999) Exp. Cell Res. 253, 1-6
36. Long, L., Rubin, R., and Brodt, P. (1998) Exp. Cell Res. 238, 116-121
37. Lahm, H., Amstad, P., Wyrdger, J., Yilmaz, A., Fischer, J. R., Schreyer, M., and Givel, J. C. (1994) Int. J. Cancer 58, 452-459
38. Peruzzi, F., Prisco, M., Dews, M., Salomoni, P., Grassilli, E., Romano, G., Calabretta, B., and Baserga, R. (1999) Mol. Cell. Biol. 19, 7203-7215
39. Burfeind, P., Chernicky, C. L., Rininsland, F., Ilan, J., and Ilan, J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7263-7281
40. Long, L., Rubin, R., Baserga, R., and Brodt, P. (1995) Cancer Res. 55, 1006-1009
41. Dunn, S. E., Torres, J. V., Nihei, N., and Barrett, J. C. (2000) Mol. Carcinog. 27, 10-17
42. Ullrich, A., Gray, A., Tam, A. W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kathuria, S., Chen, E., Jacobs, S., Francke, U., Ramachandran, J., and Fujita-Yamaguchi, Y. (1986) EMBO J. 5, 2503-2512
43. Lehmann, M., André, F., Bellan, C., Remacle-Bonnet, M., Garrouste, F., Parat, F., Lissitsky, J. C., Marvaldi, J., and Pommier, G. (1998) Endocrinology 139, 3763-3771
44. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., and White, M. F. (1991) Nature 352, 73-77
45. Berthet, V., Rigot, V., Champion, S., Secchi, J., Fouchier, F., Marvaldi, J., and Luis, J. (2000) J. Biol. Chem. 275, 33308-33313
46. Kyriazis, A. P., Kyriazis, A. A., Scarpelli, D. G., Fogh, J., Rao, M. S., and Lepera, R. (1982) Am. J. Pathol. 106, 250-260
47. Takahashi, S., Kasai, K., Hatsuzawa, K., Kitamura, N., Misumi, Y., Ikehara, Y., Murakami, K., and Nakayama, K. (1993) Biochem. Biophys. Res. Commun. 195, 1019-1026
48. Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L., and Klausner, R. D. (1991) Cell 67, 601-616
49. Trainer, D. L., Kline, T., McCabe, F. L., Faucette, L. F., Field, J., Chaikin, M., Anzano, M., Rieman, D., Hoffstein, S., Li, D. J., Gennaro, D., Buscarino, C., Lynch, M., Poste, G., and Greig, R. (1988) Int. J. Cancer 41, 287-296
50. Harvey, S. R., Sait, S. N., Xu, Y., Bailey, J. L., Penetrante, R. M., and Markus, G. (1999) Am. J. Pathol. 155, 1115-1120
51. Ganesh, S., Sier, C. F., Heerding, M. M., Griffloen, G., Lamers, C. B., and Verspaget, H. W. (1994) Lancet 344, 401-402
52. Kimura, I., Honda, R., Okai, H., and Okabe, M. (2000) Jpn. J. Pharmacol. 83, 47-55
53. Baserga, R., and Rubin, R. (1993) Crit. Rev. Eukaryotic Gene Expression 3, 47-61
54. Rodrigues, G. A., and Park, M. (1994) Curr. Opin. Genet. Dev. 4, 15-24
55. Rodrigues, G. A., and Park, M. (1994) Oncogene 9, 2019-2027
56. Werb, Z., Tremble, P. M, Behrendtsen, O., Crowley, E., and Damsky, C. H. (1989) J. Cell Biol. 109, 877-889
57. McCubrey, J. A., Steelman, L. S., Mayo, M. W., Algate, P. A., Dellow, R. A., and Kaleko, M. (1991) Blood 78, 921-929
58. Gil-Ad, I., Shtaif, B., Luria, D., Karp, L., Fridman, Y., and Weizman, A. (1999) Growth Horm. IGF Res. 9, 458-464
59. Remacle-Bonnet, M. M., Garrouste, F. L., Heller, S., Andre, F., Marvaldi, J. L., and Pommier, G. J. (2000) Cancer Res. 60, 2007-2017
60. Jung, Y., Miura, M., and Yuan, J. (1996) J. Biol. Chem. 271, 5112-5117
61. Kuhn, C., Hurwitz, S. A., Kumar, M. G., Cotton, J., and Spandau, D. F. (1999) Int. J. Cancer 80, 431-438
62. Parrizas, M., Gazit, A., Levitzki, A., Wertheimer, E., and LeRoith, D. (1997) Endocrinology 138, 1427-1433
63. Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, F., Chrétien, M., and Seidah, N. G. (2001) J. Biol. Chem. 276, 10879-10887
64. Miele, C., Formisano, P., Sohn, K. J., Caruso, M., Pianese, M., Palumbo, G., Beguino, L., and Beguinot, F. (1995) J. Biol. Chem. 270, 15844-15852
65. Cheatham, B., and Kahn, C. R. (1995) Endocr. Rev. 16, 117-142
66. White, M. F. (1997) Diabetologia 40, S2-S17
67. Lebrun, P., Mothe-Satney, I., Delahaye, L., Van Obberghen, E., and Baron, V. (1998) J. Biol. Chem. 273, 32244-32253
68. Baserga, R., Hongo, A., Rubini, M., Prisco, M., and Valentinis, B. (1997) Biochim. Biophys. Acta 1332, F105-F1260
69. Culouscou, J. M., Remacle-Bonnet, M., Garrouste, F., Marvaldi, J., and Pommier, G. (1987) Int. J. Cancer 40, 646-652
70. Akagi, Y., Liu, W., Zebrowski, B., Xie, K., and Ellis, L. M. (1998) Cancer Res. 58, 4008-4014
71. Feldser, D., Agani, F., Iyer, N. V., Pak, B., Ferreira, G., and Semenza, G. L. (1999) Cancer Res. 59, 3915-3918
72. Koshikawa, N., Giannelli, G., Cirulli, V., Miyazaki, K., and Quaranta, V. (2000) J. Cell Biol. 148, 615-624
73. Kinoshita, T., Sato, H., Takino, T., Itoh, M., Akizawa, T., and Seiki, M. (1996) Cancer Res. 56, 2535-2538
74. Pei, D., and Weiss, S. J. (1996) J. Biol. Chem. 271, 9135-9140