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Volumn 65, Issue 10, 2005, Pages 4162-4171

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME PRECURSOR; FURIN; INTERSTITIAL COLLAGENASE; PROPROTEIN CONVERTASE 1; SOMATOMEDIN C RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN; VASCULOTROPIN C;

EID: 20144371230     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2820     Document Type: Article
Times cited : (49)

References (48)
  • 1
    • 0031995477 scopus 로고    scopus 로고
    • The proprotein convertases
    • Steiner DF. The proprotein convertases. Curr Opin Chem Biol 1998;2:31-9.
    • (1998) Curr Opin Chem Biol , vol.2 , pp. 31-39
    • Steiner, D.F.1
  • 2
    • 0026775916 scopus 로고
    • Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
    • Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR, Thomas G. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem 1992;267:16396-402.
    • (1992) J Biol Chem , vol.267 , pp. 16396-16402
    • Molloy, S.S.1    Bresnahan, P.A.2    Leppla, S.H.3    Klimpel, K.R.4    Thomas, G.5
  • 3
    • 0343307146 scopus 로고    scopus 로고
    • Eukaryotic protein processing: Endoproteolysis of precursor proteins
    • Seidah NG, Chretien M. Eukaryotic protein processing: endoproteolysis of precursor proteins. Curr Opin Biotechnol 1997;8:602-7.
    • (1997) Curr Opin Biotechnol , vol.8 , pp. 602-607
    • Seidah, N.G.1    Chretien, M.2
  • 4
    • 0034723309 scopus 로고    scopus 로고
    • Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment
    • Toure BB, Munzer JS, Basak A, et al. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment. J Biol Chem 2000;275:2349-58.
    • (2000) J Biol Chem , vol.275 , pp. 2349-2358
    • Toure, B.B.1    Munzer, J.S.2    Basak, A.3
  • 5
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
    • Seidah NG, Benjannet S, Wickham L, et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA 2003;100:928-33.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 7
    • 0030577022 scopus 로고    scopus 로고
    • Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
    • Sato H, Kinoshita T, Takino T, Nakayama K, Seiki M. Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. FEBS Lett 1996;393:101-4.
    • (1996) FEBS Lett , vol.393 , pp. 101-104
    • Sato, H.1    Kinoshita, T.2    Takino, T.3    Nakayama, K.4    Seiki, M.5
  • 8
    • 0035903230 scopus 로고    scopus 로고
    • Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: Importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions
    • Khatib AM, Siegfried G, Prat A, et al. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J Biol Chem 2001;276:30686-93.
    • (2001) J Biol Chem , vol.276 , pp. 30686-30693
    • Khatib, A.M.1    Siegfried, G.2    Prat, A.3
  • 9
    • 0030909584 scopus 로고    scopus 로고
    • Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours
    • Mbikay M, Sirois F, Yao J, Seidah NG, Chretien M. Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. Br J Cancer 1997;75:1509-14.
    • (1997) Br J Cancer , vol.75 , pp. 1509-1514
    • Mbikay, M.1    Sirois, F.2    Yao, J.3    Seidah, N.G.4    Chretien, M.5
  • 13
    • 0028107656 scopus 로고
    • Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
    • Molloy SS, Thomas L, VanSlyke JK, Stenberg PE, Thomas G. Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J 1994;13:18-33.
    • (1994) EMBO J , vol.13 , pp. 18-33
    • Molloy, S.S.1    Thomas, L.2    VanSlyke, J.K.3    Stenberg, P.E.4    Thomas, G.5
  • 14
    • 0026721473 scopus 로고
    • Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage
    • Leduc R, Molloy SS, Thorne BA, Thomas G. Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. J Biol Chem 1992;267:14304-8.
    • (1992) J Biol Chem , vol.267 , pp. 14304-14308
    • Leduc, R.1    Molloy, S.S.2    Thorne, B.A.3    Thomas, G.4
  • 15
    • 0031001304 scopus 로고    scopus 로고
    • Activation of the furin endoprotease is a multiple-step process: Requirements for acidification and internal propeptide cleavage
    • Anderson ED, VanSlyke JK, Thulin CD, Jean F, Thomas G. Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. EMBO J 1997;16:1508-18.
    • (1997) EMBO J , vol.16 , pp. 1508-1518
    • Anderson, E.D.1    VanSlyke, J.K.2    Thulin, C.D.3    Jean, F.4    Thomas, G.5
  • 16
    • 0029279566 scopus 로고
    • Proprotein convertases and the pathophysiology of human diseases: Prospective considerations
    • Chretien M, Mbikay M, Caspar L, Seidah NG. Proprotein convertases and the pathophysiology of human diseases: prospective considerations. Proc Assoc Am Physicians 1995;107:47-66.
    • (1995) Proc Assoc Am Physicians , vol.107 , pp. 47-66
    • Chretien, M.1    Mbikay, M.2    Caspar, L.3    Seidah, N.G.4
  • 17
    • 0029135124 scopus 로고
    • Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor
    • Jean F, Boudreault A, Basak A, Seidah NG, Lazure C. Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor. J Biol Chem 1995;270:19225-31.
    • (1995) J Biol Chem , vol.270 , pp. 19225-19231
    • Jean, F.1    Boudreault, A.2    Basak, A.3    Seidah, N.G.4    Lazure, C.5
  • 18
    • 0028828914 scopus 로고
    • Peptidyl substrates containing unnatural amino acid at the P′1 position are potent inhibitors of prohormone convertases
    • Basak A, Schmidt C, Ismail AA, Seidah NG, Chretien M, Lazure C. Peptidyl substrates containing unnatural amino acid at the P′1 position are potent inhibitors of prohormone convertases. Int J Pept Protein Res 1995;46:228-37.
    • (1995) Int J Pept Protein Res , vol.46 , pp. 228-237
    • Basak, A.1    Schmidt, C.2    Ismail, A.A.3    Seidah, N.G.4    Chretien, M.5    Lazure, C.6
  • 19
    • 0027337354 scopus 로고
    • 18 turkey ovomucoid third domain inhibits human furin
    • 18 turkey ovomucoid third domain inhibits human furin. J Biol Chem 1993;268:14583-5.
    • (1993) J Biol Chem , vol.268 , pp. 14583-14585
    • Lu, W.1    Zhang, W.2    Molloy, S.S.3
  • 20
    • 0031917385 scopus 로고    scopus 로고
    • Inhibition of soluble recombinant furin by human proteinase inhibitor 8
    • Dahlen JR, Jean F, Thomas G, Foster DC, Kisiel W. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. J Biol Chem 1998;273:1851-4.
    • (1998) J Biol Chem , vol.273 , pp. 1851-1854
    • Dahlen, J.R.1    Jean, F.2    Thomas, G.3    Foster, D.C.4    Kisiel, W.5
  • 21
    • 0030805194 scopus 로고    scopus 로고
    • Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered α2-macroglobulin containing a furin recognition sequence in the bait region
    • Van Rompaey L, Ayoubi T, Van De Ven W, Marynen P. Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered α2-macroglobulin containing a furin recognition sequence in the bait region. Biochem J 1997;326:507-14.
    • (1997) Biochem J , vol.326 , pp. 507-514
    • Van Rompaey, L.1    Ayoubi, T.2    Van De Ven, W.3    Marynen, P.4
  • 22
    • 0032560449 scopus 로고    scopus 로고
    • α1-antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent
    • Jean F, Stella K, Thomas L, et al. α1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A 1998;95:7293-8.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7293-7298
    • Jean, F.1    Stella, K.2    Thomas, L.3
  • 24
    • 0033607676 scopus 로고    scopus 로고
    • The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
    • Zhong M, Munzer JS, Basak A, et al. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. J Biol Chem 1999;274:33913-20.
    • (1999) J Biol Chem , vol.274 , pp. 33913-33920
    • Zhong, M.1    Munzer, J.S.2    Basak, A.3
  • 26
    • 0037332088 scopus 로고    scopus 로고
    • Increased furin activity enhances the malignant phenotype of human head and neck cancer cells
    • Bassi DE, Mahloogi H, Lopez De Cicco R, Klein-Szanto A. Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol 2003;162:439-47.
    • (2003) Am J Pathol , vol.162 , pp. 439-447
    • Bassi, D.E.1    Mahloogi, H.2    Lopez De Cicco, R.3    Klein-Szanto, A.4
  • 27
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 28
    • 0031844617 scopus 로고    scopus 로고
    • Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor
    • Long L, Rubin R, Brodt P. Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. Exp Cell Res 1998;238:116-21.
    • (1998) Exp Cell Res , vol.238 , pp. 116-121
    • Long, L.1    Rubin, R.2    Brodt, P.3
  • 30
    • 0023915778 scopus 로고
    • Biological characterization and oncogene expression in human colorectal carcinoma cell lines
    • Trainer DE, Kline T, McCabe FE, et al. Biological characterization and oncogene expression in human colorectal carcinoma cell lines. Int J Cancer 1988;41:287-96.
    • (1988) Int J Cancer , vol.41 , pp. 287-296
    • Trainer, D.E.1    Kline, T.2    McCabe, F.E.3
  • 31
    • 0035000670 scopus 로고    scopus 로고
    • Proteases in invasion: Matrix metalloproteinases
    • Stetler-Stevenson WG, Yu AE. Proteases in invasion: matrix metalloproteinases. Semin Cancer Biol 2001;11:143-52.
    • (2001) Semin Cancer Biol , vol.11 , pp. 143-152
    • Stetler-Stevenson, W.G.1    Yu, A.E.2
  • 32
    • 0037409415 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma
    • Kishimoto K, Sasaki A, Yoshihama Y, Mese H, Tsukamoto G, Matsumura T. Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma. Oral Oncol 2003;39:391-6.
    • (2003) Oral Oncol , vol.39 , pp. 391-396
    • Kishimoto, K.1    Sasaki, A.2    Yoshihama, Y.3    Mese, H.4    Tsukamoto, G.5    Matsumura, T.6
  • 33
    • 0037936730 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck
    • Neuchrist C, Erovic BM, Handisurya A, et al. Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck. Head Neck 2003;25:464-74.
    • (2003) Head Neck , vol.25 , pp. 464-474
    • Neuchrist, C.1    Erovic, B.M.2    Handisurya, A.3
  • 34
    • 0037332088 scopus 로고    scopus 로고
    • Increased furin activity enhances the malignant phenotype of human head and neck cancer cells
    • Bassi DE, Mahloogi H, Lopez De Cicco R, Klein-Szanto A. Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol 2003;162:439-47.
    • (2003) Am J Pathol , vol.162 , pp. 439-447
    • Bassi, D.E.1    Mahloogi, H.2    Lopez De Cicco, R.3    Klein-Szanto, A.4
  • 35
    • 0038481179 scopus 로고    scopus 로고
    • The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
    • Siegfried G, Basak A, Cromlish JA, et al. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J Clin Invest 2003;111:1723-32.
    • (2003) J Clin Invest , vol.111 , pp. 1723-1732
    • Siegfried, G.1    Basak, A.2    Cromlish, J.A.3
  • 36
    • 0029903248 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor invasion: From correlation and causality to the clinic
    • Stetler-Stevenson WG, Hewitt R, Corcoran M. Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic. Semin Cancer Biol 1996;7:147-54.
    • (1996) Semin Cancer Biol , vol.7 , pp. 147-154
    • Stetler-Stevenson, W.G.1    Hewitt, R.2    Corcoran, M.3
  • 37
    • 0035793842 scopus 로고    scopus 로고
    • Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers
    • Kerkela E, Ala-aho R, Lohi J, Grenman R, V MK, Saarialho-Kere U. Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. Br J Cancer 2001;84:659-69.
    • (2001) Br J Cancer , vol.84 , pp. 659-669
    • Kerkela, E.1    Ala-Aho, R.2    Lohi, J.3    Grenman, R.4    Saarialho-Kere, U.5
  • 38
    • 0035153463 scopus 로고    scopus 로고
    • Role of transforming growth factor β in cancer
    • Pasche B. Role of transforming growth factor β in cancer. J Cell Physiol 2001;186:153-68.
    • (2001) J Cell Physiol , vol.186 , pp. 153-168
    • Pasche, B.1
  • 39
    • 0028070655 scopus 로고
    • Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF-II-mediated autocrine loop
    • Lahm H, Amstad P, Wyniger J, et al. Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop. Int J Cancer 1994;58:452-9.
    • (1994) Int J Cancer , vol.58 , pp. 452-459
    • Lahm, H.1    Amstad, P.2    Wyniger, J.3
  • 40
    • 0028920352 scopus 로고
    • Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor
    • Long L, Rubin R, Baserga R, Brodt P. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Res 1995;55:1006-9.
    • (1995) Cancer Res , vol.55 , pp. 1006-1009
    • Long, L.1    Rubin, R.2    Baserga, R.3    Brodt, P.4
  • 41
    • 0031844617 scopus 로고    scopus 로고
    • Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor
    • Long L, Rubin R, Brodt P. Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. Exp Cell Res 1998;238:116-21.
    • (1998) Exp Cell Res , vol.238 , pp. 116-121
    • Long, L.1    Rubin, R.2    Brodt, P.3
  • 42
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor 1 receptor gene on growth and transformation of mouse embryo fibroblasts
    • Sell C, Dumenil G, Deveaud C, et al. Effect of a null mutation of the insulin-like growth factor 1 receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 1994;14:3604-12.
    • (1994) Mol Cell Biol , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3
  • 43
    • 0026438156 scopus 로고
    • Angiogenesis-retrospect and outlook
    • Folkman J. Angiogenesis-retrospect and outlook. EXS 1992;61:4-13.
    • (1992) EXS , vol.61 , pp. 4-13
    • Folkman, J.1
  • 44
    • 0029929046 scopus 로고    scopus 로고
    • Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms
    • Abu-Jawdeh GM, Faix JD, Niloff J, et al. Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab Invest 1996;74:1105-15.
    • (1996) Lab Invest , vol.74 , pp. 1105-1115
    • Abu-Jawdeh, G.M.1    Faix, J.D.2    Niloff, J.3
  • 45
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995;55:3964-8.
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 46
    • 18844471324 scopus 로고    scopus 로고
    • Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors
    • Salven P, Lymboussaki A, Heikkila P, et al. Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. Am J Pathol 1998;153:103-8.
    • (1998) Am J Pathol , vol.153 , pp. 103-108
    • Salven, P.1    Lymboussaki, A.2    Heikkila, P.3
  • 47
    • 0037936730 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck
    • Neuchrist C, Erovic BM, Handisurya A, et al. Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck. Head Neck 2003;25:464-74.
    • (2003) Head Neck , vol.25 , pp. 464-474
    • Neuchrist, C.1    Erovic, B.M.2    Handisurya, A.3
  • 48
    • 3042852155 scopus 로고    scopus 로고
    • Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression
    • Lopez de Cicco R, Watson JC, Bassi DE, Litwin S, Klein-Szanto AJ. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Clin Cancer Res 2004;10:4480-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 4480-4488
    • Lopez De Cicco, R.1    Watson, J.C.2    Bassi, D.E.3    Litwin, S.4    Klein-Szanto, A.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.