Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain

Current Medicinal Chemistry

Volumn 17, Issue 21, 2010, Pages 2214-2221

  Basak, A ^a   Chen, A ^a   Scamuffa, N ^b,c   Mohottalage, D ^a   Basak, S ^a   Khatib, A M ^b,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Anticancer activity; Furin inhibitor; Growth factor precursor processing; Invasion; Migration; Prodomain; Proliferation; Proprotein convertases

Indexed keywords

COMPLEMENTARY DNA; FURIN; ANTINEOPLASTIC AGENT;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE SYNTHESIS; TUMOR CELL; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CELL MOTION; CHEMISTRY; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TUMOR CELL CULTURE;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL MOVEMENT; FURIN; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TUMOR CELLS, CULTURED;

EID: 77955623211     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710791331040     Document Type: Article

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