Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling

Cancer Science

Volumn 105, Issue 3, 2014, Pages 324-333

  Morifuji, Yoshihiro ^a   Onishi, Hideya ^a   Iwasaki, Hironori ^a,b   Imaizumi, Akira ^c   Nakano, Kenji ^b   Tanaka, Masao ^a   Katano, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c Shukoukai Inc   (Japan)

Author keywords

Hedgehog; Invasiveness; Pancreatic cancer; Proliferation; Reoxygenation

Indexed keywords

GELATINASE A; GELATINASE B; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME REPRESSION; FEMALE; HUMAN; HYPOXIA; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS METASTASIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; RNA TRANSCRIPTION; TUMOR INVASION;

HEDGEHOG; INVASIVENESS; PANCREATIC CANCER; PROLIFERATION; REOXYGENATION;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; HEDGEHOG PROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; MICE, NUDE; OXYGEN; PANCREATIC NEOPLASMS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84895561406     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12348     Document Type: Article

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