Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases - Activation of cell invasion and migration pathways

Liver Transplantation

Volumn 13, Issue 12, 2007, Pages 1669-1677

  Man, Kwan ^a   Ng, Kevin T ^a   Lo, Chung Mau ^a   Ho, Joanna W ^a   Sun, Bai Shun ^a   Sun, Chris K ^a   Lee, Terence K ^a   Poon, Ronnie T P ^a   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN CDC42; RHO KINASE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CELL ACTIVATION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; LIVER CARCINOGENESIS; LIVER ISCHEMIA; LIVER METASTASIS; LIVER RESECTION; LIVER TUMOR; LUNG METASTASIS; MALE; METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; NUDE MOUSE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; STELLATE CELL; SURGICAL STRESS; TUMOR GROWTH; TUMOR PROMOTION; TUMOR VASCULARIZATION; UPREGULATION;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EARLY GROWTH RESPONSE PROTEIN 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HEPATECTOMY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; PHOSPHORYLATION; RAC1 GTP-BINDING PROTEIN; RATS; RATS, INBRED BUF; REPERFUSION INJURY; RHO-ASSOCIATED KINASES; RISK FACTORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 37549030135     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.21193     Document Type: Article

References (24)

1. Doi K, Horiuchi T, Uchinami M, Tabo T, Kimura N, Yokomachi J, et al. Hepatic ischemia-reperfusion promotes liver metastasis of colon cancer. J Surg Res 2002; 105:243-247.
2. van der Bilt JD, Kranenburg O, Nijkamp MW, Smakman N, Veenendaal LM, Te Velde EA, et al. Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model. Hepatology 2005; 42:165-175.
3. Picardo A, Karpoff HM, Ng B, Lee J, Brennan MF, Fong Y. Partial hepatectomy accelerates local tumor growth: potential roles of local cytokine activation. Surgery 1998; 124:57-64.
4. Ikeda Y, Matsumata T, Takenaka K, Sasaki O, Soejima K, Sugimachi K. Preliminary report of tumor metastasis during liver regeneration after hepatic resection in rats. Eur J Surg Oncol 1995;21:188-190.
5. Lo CM, Fan ST, Liu CL, Chan SC, Ng IOL, Wong J. Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma: same criteria, different outcome. British Journal of Surgery 2006;94: 78-86.
6. Kulik L, Abecassis M. Living donor liver transplantation for hepatocellular carcinoma. Grastroenterology 2004; 127 (5 Suppl 1):S227-S282.
7. Sahai E, Olson MF, Marshall CJ. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J 2001;20: 755-766.
8. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 1999;5:221-225.
9. Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, et al. Activation of Rae 1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 2002;21:6791-6800.
10. Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, et al. Inhibition of the Racl GTPase protects against nonlethal ischemia/ reperfusion-induced necrosis and apoptosis in vivo. FASEB J 2000; 14:418-429.
11. Schmitz V, Barajas M, Wang L, Peng D, Duarte M, Prieto J, et al. Adenovirus-mediated CD40 ligand gene therapy in a rat model of orthotopic hepatocellular carcinoma. Hepatology 2001;34:72-81.
12. Lee TK, Man K, Ho JW, Wang XH, Poon RT, Xu Y, et al. FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Clin Cancer Res 2005; 11:8458-8466.
13. Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM. Transcription factor Egr- 1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nat Med 2003;9:1026-1032.
14. Man K, Fan ST, Lo CM, Liu CL, Fung PC, Liang TB, et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003;237:256-264.
15. Man K, Su M, Ng KTP, Lo CM, Zhao, Y, Ho JW, et al. Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK- VEGF pathway. Am J Transpl 2006;6:697-704.
16. Drixler TA, Vogten MJ, Ritchie ED, van Vroonhoven TJ, Gebbink MF, Voest EE, et al. Liver regeneration is an angiogenesis- associated phenomenon. Ann Surg 2002; 236:703-711.
17. Greene AK, Wiener S, Puder M, Yoshida A, Shi B, Perez-Atayde AR, et al. Endothelial-directed hepatic regeneration after partial hepatectomy. Ann Surg 2003;237:530-535.
18. Man K, Lee Terence, Liang TB, Lo CM, Fung PC, Tsui SH, et al. FK409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr- 1 pathway. Ann Surg 2004; 240:159-168.
19. Liang TB, Man K, Lee Terence, Hong-Teng Tsui S, Lo CM, Xu X, et al. Distinct intragraft response pattern in relation to graft size in liver transplantation. Transplantation 2003;75:673-678.
20. Man K, Lo CM, Lee Terence, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA Microarray in small-for-size liver grafts. Liver Transpl 2003;9:425-432.
21. Man K, Ng KTP, Lee TKW, Lo CM, Sun CK, Li XL, et al. FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic liver. Am J Transpl 2005;5:40-49.
22. Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, et al. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene 2005;24:7821-7829.
23. Ogawa T, Tashiro H, Miyata Y, Ushitora Y, Fudaba Y, Kobayashi T, et al. Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model. Am J Transplant 2007;7:347-355.
24. Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol 2003:160:753-767.