메뉴 건너뛰기




Volumn 6, Issue 1, 2014, Pages 436-458

The role of cyclic nucleotide signaling pathways in cancer: Targets for prevention and treatment

Author keywords

cAMP; cGMP; Cyclic nucleotide phosphodiesterases; Cyclic nucleotides; PKA; PKG; Protein kinases

Indexed keywords

8 METHOXYMETHYL IBMX; ADENYLATE CYCLASE; AWD 12281; BAY 607550; CILOMILAST; CILOSTAMIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DENBUFYLLINE; DIPYRIDAMOLE; ENZYME INHIBITOR; G PROTEIN COUPLED RECEPTOR; IC 224; IC 933; ICH 224; MILRINONE; PAPAVERINE; RO20 1724; ROFLUMILAST; ROLIPRAM; SH 51866; SILDENAFIL; TADALAFIL; TOLAFENTRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; ZAPRINAST;

EID: 84895529193     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6010436     Document Type: Review
Times cited : (169)

References (133)
  • 1
    • 46849106085 scopus 로고    scopus 로고
    • Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility
    • Gerits, N., Kostenko, S., Shiryaev, A., Johannessen, M., Moens, U. Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cell. Signal. 2008, 20, 1592-1607.
    • (2008) Cell. Signal , vol.20 , pp. 1592-1607
    • Gerits, N.1    Kostenko, S.2    Shiryaev, A.3    Johannessen, M.4    Moens, U.5
  • 2
  • 3
    • 33845800991 scopus 로고    scopus 로고
    • Capturing cyclic nucleotides in action: Snapshots from crystallographic studies
    • Rehmann, H., Wittinghofer, A., Bos, J.L. Capturing cyclic nucleotides in action: Snapshots from crystallographic studies. Nat. Rev. Mol. Cell Biol. 2007, 8, 63-73.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 63-73
    • Rehmann, H.1    Wittinghofer, A.2    Bos, J.L.3
  • 4
    • 0028838122 scopus 로고
    • Mammalian membrane-bound adenylyl cyclases
    • Taussig, R., Gilman, A.G. Mammalian membrane-bound adenylyl cyclases. J. Biol. Chem. 1995, 270, 1-4.
    • (1995) J. Biol. Chem , vol.270 , pp. 1-4
    • Taussig, R.1    Gilman, A.G.2
  • 5
    • 0035040818 scopus 로고    scopus 로고
    • Regulation and role of adenylyl cyclase isoforms
    • Hanoune, J., Defer, N. Regulation and role of adenylyl cyclase isoforms. Annu. Rev. Pharmacol. Toxicol. 2001, 41, 145-174.
    • (2001) Annu. Rev. Pharmacol. Toxicol , vol.41 , pp. 145-174
    • Hanoune, J.1    Defer, N.2
  • 6
    • 84875172143 scopus 로고    scopus 로고
    • Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease
    • Lee, L.C., Maurice, D.H., Baillie, G.S. Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Future Med. Chem. 2013, 5, 451-464.
    • (2013) Future Med. Chem , vol.5 , pp. 451-464
    • Lee, L.C.1    Maurice, D.H.2    Baillie, G.S.3
  • 7
    • 0021023294 scopus 로고
    • Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes
    • Buxton, I.L., Brunton, L.L. Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes. J. Biol. Chem. 1983, 258, 10233-10239.
    • (1983) J. Biol. Chem , vol.258 , pp. 10233-10239
    • Buxton, I.L.1    Brunton, L.L.2
  • 8
    • 84863295466 scopus 로고    scopus 로고
    • Multidrug resistance associated proteins in multidrug resistance
    • Sodani, K., Patel, A., Kathawala, R.J., Chen, Z.-S. Multidrug resistance associated proteins in multidrug resistance. Chin. J. Cancer 2012, 31, 58-72.
    • (2012) Chin. J. Cancer , vol.31 , pp. 58-72
    • Sodani, K.1    Patel, A.2    Kathawala, R.J.3    Chen, Z.-S.4
  • 10
    • 0037705377 scopus 로고    scopus 로고
    • Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells
    • Wielinga, P.R., van der Heijden, I., Reid, G., Beijnen, J.H., Wijnholds, J., Borst, P. Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells. J. Biol. Chem. 2003, 278, 17664-17671.
    • (2003) J. Biol. Chem , vol.278 , pp. 17664-17671
    • Wielinga, P.R.1    van der Heijden, I.2    Reid, G.3    Beijnen, J.H.4    Wijnholds, J.5    Borst, P.6
  • 11
    • 33847068206 scopus 로고    scopus 로고
    • Overview of PDEs and their regulation
    • Omori, K., Kotera, J. Overview of PDEs and their regulation. Circ. Res. 2007, 100, 309-327.
    • (2007) Circ. Res , vol.100 , pp. 309-327
    • Omori, K.1    Kotera, J.2
  • 12
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
    • Conti, M., Beavo, J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 2007, 76, 481-511.
    • (2007) Annu. Rev. Biochem , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 14
    • 69049103114 scopus 로고    scopus 로고
    • Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia
    • Verhoest, P.R., Chapin, D.S., Corman, M., Fonseca, K., Harms, J.F., Hou, X., Marr, E.S., Menniti, F.S., Nelson, F., O'Connor, R., et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J. Med. Chem. 2009, 52, 5188-5196.
    • (2009) J. Med. Chem , vol.52 , pp. 5188-5196
    • Verhoest, P.R.1    Chapin, D.S.2    Corman, M.3    Fonseca, K.4    Harms, J.F.5    Hou, X.6    Marr, E.S.7    Menniti, F.S.8    Nelson, F.9    O'Connor, R.10
  • 15
    • 80053141755 scopus 로고    scopus 로고
    • Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: A potential translational biomarker
    • Dedeurwaerdere, S., Wintmolders, C., Vanhoof, G., Langlois, X. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: A potential translational biomarker. J. Pharmacol. Exp. Ther. 2011, 339, 210-217.
    • (2011) J. Pharmacol. Exp. Ther , vol.339 , pp. 210-217
    • Dedeurwaerdere, S.1    Wintmolders, C.2    Vanhoof, G.3    Langlois, X.4
  • 16
    • 84856393433 scopus 로고    scopus 로고
    • Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen
    • Ceyhan, O., Birsoy, K., Hoffman, C.S. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem. Biol. 2012, 19, 155-163.
    • (2012) Chem. Biol , vol.19 , pp. 155-163
    • Ceyhan, O.1    Birsoy, K.2    Hoffman, C.S.3
  • 17
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • Bender, A.T., Beavo, J.A. Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol. Rev. 2006, 58, 488-520.
    • (2006) Pharmacol. Rev , vol.58 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 18
    • 0032848914 scopus 로고    scopus 로고
    • Cyclic nucleotide-dependent protein kinases: Intracellular receptors for cAMP and cGMP action
    • Francis, S.H., Corbin, J.D. Cyclic nucleotide-dependent protein kinases: Intracellular receptors for cAMP and cGMP action. Crit. Rev. Clin. Lab. Sci. 1999, 36, 275-328.
    • (1999) Crit. Rev. Clin. Lab. Sci , vol.36 , pp. 275-328
    • Francis, S.H.1    Corbin, J.D.2
  • 19
    • 0036729478 scopus 로고    scopus 로고
    • Cyclic nucleotide research-Still expanding after half a century
    • Beavo, J.A., Brunton, L.L. Cyclic nucleotide research-Still expanding after half a century. Nat. Rev. Mol. Cell Biol. 2002, 3, 710-718.
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 710-718
    • Beavo, J.A.1    Brunton, L.L.2
  • 20
    • 0034616226 scopus 로고    scopus 로고
    • UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions
    • Beard, M.B., Olsen, A.E., Jones, R.E., Erdogan, S., Houslay, M.D., Bolger, G.B. UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions. J. Biol. Chem. 2000, 275, 10349-10358.
    • (2000) J. Biol. Chem , vol.275 , pp. 10349-10358
    • Beard, M.B.1    Olsen, A.E.2    Jones, R.E.3    Erdogan, S.4    Houslay, M.D.5    Bolger, G.B.6
  • 21
    • 70349106337 scopus 로고    scopus 로고
    • The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue
    • Goncalves, R.L., Lugnier, C., Keravis, T., Lopes, M.J., Fantini, F.A., Schmitt, M., Cortes, S.F., Lemos, V.S. The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue. Eur. J. Pharmacol. 2009, 620, 78-83.
    • (2009) Eur. J. Pharmacol , vol.620 , pp. 78-83
    • Goncalves, R.L.1    Lugnier, C.2    Keravis, T.3    Lopes, M.J.4    Fantini, F.A.5    Schmitt, M.6    Cortes, S.F.7    Lemos, V.S.8
  • 22
  • 23
    • 79953725149 scopus 로고    scopus 로고
    • Protein kinase A in cancer
    • Caretta, A., Mucignat-Caretta, C. Protein kinase A in cancer. Cancers 2011, 3, 913-926.
    • (2011) Cancers , vol.3 , pp. 913-926
    • Caretta, A.1    Mucignat-Caretta, C.2
  • 25
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation-dependent factor CREB
    • Mayr, B., Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2001, 2, 599-609.
    • (2001) Nat. Rev. Mol. Cell Biol , vol.2 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 26
    • 65249140538 scopus 로고    scopus 로고
    • CREB in the pathophysiology of cancer: Implications for targeting transcription factors for cancer therapy
    • Sakamoto, K.M., Frank, D.A. CREB in the pathophysiology of cancer: Implications for targeting transcription factors for cancer therapy. Clin. Cancer Res. 2009, 15, 2583-2587.
    • (2009) Clin. Cancer Res , vol.15 , pp. 2583-2587
    • Sakamoto, K.M.1    Frank, D.A.2
  • 27
    • 33645837833 scopus 로고    scopus 로고
    • cGMP signalling: From bench to bedside. Conference on cGMP generators, effectors and therapeutic implications
    • Feil, R., Kemp-Harper, B. cGMP signalling: From bench to bedside. Conference on cGMP generators, effectors and therapeutic implications. EMBO Rep. 2006, 7, 149-153.
    • (2006) EMBO Rep , vol.7 , pp. 149-153
    • Feil, R.1    Kemp-Harper, B.2
  • 28
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo, J.A. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol. Rev. 1995, 75, 725-748.
    • (1995) Physiol. Rev , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 29
    • 0027404913 scopus 로고
    • Intracellular cyclic GMP receptor proteins
    • Lincoln, T.M., Cornwell, T.L. Intracellular cyclic GMP receptor proteins. FASEB J. 1993, 7, 328-338.
    • (1993) FASEB J , vol.7 , pp. 328-338
    • Lincoln, T.M.1    Cornwell, T.L.2
  • 30
    • 41049095471 scopus 로고    scopus 로고
    • Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer
    • Browning, D.D. Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer. Expert Opin. Ther. Targets 2008, 12, 367-376.
    • (2008) Expert Opin. Ther. Targets , vol.12 , pp. 367-376
    • Browning, D.D.1
  • 31
    • 57649155045 scopus 로고    scopus 로고
    • Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
    • Das, A., Xi, L., Kukreja, R.C. Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. J. Biol. Chem. 2008, 283, 29572-29585.
    • (2008) J. Biol. Chem , vol.283 , pp. 29572-29585
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 32
    • 0032989849 scopus 로고    scopus 로고
    • Cyclic GMP-dependent protein kinases: Understanding in vivo functions by gene targeting
    • Ruth, P. Cyclic GMP-dependent protein kinases: Understanding in vivo functions by gene targeting. Pharmacol. Ther. 1999, 82, 355-372.
    • (1999) Pharmacol. Ther , vol.82 , pp. 355-372
    • Ruth, P.1
  • 33
    • 77956283047 scopus 로고    scopus 로고
    • cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
    • Francis, S.H., Busch, J.L., Corbin, J.D., Sibley, D. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol. Rev. 2010, 62, 525-563.
    • (2010) Pharmacol. Rev , vol.62 , pp. 525-563
    • Francis, S.H.1    Busch, J.L.2    Corbin, J.D.3    Sibley, D.4
  • 35
    • 0034234978 scopus 로고    scopus 로고
    • Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin
    • Thompson, W.J., Piazza, G.A., Li, H., Liu, L., Fetter, J., Zhu, B., Sperl, G., Ahnen, D., Pamukcu, R. Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000, 60, 3338-3342.
    • (2000) Cancer Res , vol.60 , pp. 3338-3342
    • Thompson, W.J.1    Piazza, G.A.2    Li, H.3    Liu, L.4    Fetter, J.5    Zhu, B.6    Sperl, G.7    Ahnen, D.8    Pamukcu, R.9
  • 36
    • 2542619027 scopus 로고    scopus 로고
    • Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells
    • Deguchi, A., Thompson, W.J., Weinstein, I.B. Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. Cancer Res. 2004, 64, 3966-3973.
    • (2004) Cancer Res , vol.64 , pp. 3966-3973
    • Deguchi, A.1    Thompson, W.J.2    Weinstein, I.B.3
  • 38
    • 0036690669 scopus 로고    scopus 로고
    • Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G
    • Deguchi, A., Soh, J.W., Li, H., Pamukcu, R., Thompson, W.J., Weinstein, I.B. Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G. Mol. Cancer Ther. 2002, 1, 803-809.
    • (2002) Mol. Cancer Ther , vol.1 , pp. 803-809
    • Deguchi, A.1    Soh, J.W.2    Li, H.3    Pamukcu, R.4    Thompson, W.J.5    Weinstein, I.B.6
  • 39
    • 0027172155 scopus 로고
    • 3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition
    • Drees, M., Zimmermann, R., Eisenbrand, G. 3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition. Cancer Res. 1993, 53, 3058-3061.
    • (1993) Cancer Res , vol.53 , pp. 3058-3061
    • Drees, M.1    Zimmermann, R.2    Eisenbrand, G.3
  • 41
    • 0142158595 scopus 로고    scopus 로고
    • Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival
    • Whitehead, C.M., Earle, K.A., Fetter, J., Xu, S., Hartman, T., Chan, D.C., Zhao, T.L., Piazza, G., Klein-Szanto, A.J., Pamukcu, R., et al. Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol. Cancer Ther. 2003, 2, 479-488.
    • (2003) Mol. Cancer Ther , vol.2 , pp. 479-488
    • Whitehead, C.M.1    Earle, K.A.2    Fetter, J.3    Xu, S.4    Hartman, T.5    Chan, D.C.6    Zhao, T.L.7    Piazza, G.8    Klein-Szanto, A.J.9    Pamukcu, R.10
  • 42
    • 33847644982 scopus 로고    scopus 로고
    • The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels
    • Zhu, B., Strada, S.J. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr. Top. Med. Chem. 2007, 7, 437-454.
    • (2007) Curr. Top. Med. Chem , vol.7 , pp. 437-454
    • Zhu, B.1    Strada, S.J.2
  • 43
    • 22444447950 scopus 로고    scopus 로고
    • Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells
    • Zhu, B., Strada, S., Stevens, T. Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 289, L196-L206.
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.289
    • Zhu, B.1    Strada, S.2    Stevens, T.3
  • 44
    • 0029745055 scopus 로고    scopus 로고
    • Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells
    • Jiang, X., Li, J., Paskind, M., Epstein, P.M. Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc. Natl. Acad. Sci. USA 1996, 93, 11236-11241.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11236-11241
    • Jiang, X.1    Li, J.2    Paskind, M.3    Epstein, P.M.4
  • 46
    • 30044446499 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies
    • Lerner, A., Epstein, P.M. Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem. J. 2006, 393, 21-41.
    • (2006) Biochem. J , vol.393 , pp. 21-41
    • Lerner, A.1    Epstein, P.M.2
  • 47
    • 0018949663 scopus 로고
    • Elevated plasma and urinary guanosine 3':5'-monophosphate and increased production rate in patients with neoplastic diseases
    • Chawla, R.K., Shlaer, S.M., Lawson, D.H., Murray, T.G., Schmidt, F., Shoji, M., Nixon, D.W., Richmond, A., Rudman, D. Elevated plasma and urinary guanosine 3':5'-monophosphate and increased production rate in patients with neoplastic diseases. Cancer Res. 1980, 40, 3915-3920.
    • (1980) Cancer Res , vol.40 , pp. 3915-3920
    • Chawla, R.K.1    Shlaer, S.M.2    Lawson, D.H.3    Murray, T.G.4    Schmidt, F.5    Shoji, M.6    Nixon, D.W.7    Richmond, A.8    Rudman, D.9
  • 48
    • 0018639672 scopus 로고
    • Plasma and urine cyclic guanosine 3':5'-monophosphate in disseminated cancer
    • Chawla, R.K., Nixon, D.W., Shoji, M., Rudman, D. Plasma and urine cyclic guanosine 3':5'-monophosphate in disseminated cancer. Ann. Intern. Med. 1979, 91, 862-864.
    • (1979) Ann. Intern. Med , vol.91 , pp. 862-864
    • Chawla, R.K.1    Nixon, D.W.2    Shoji, M.3    Rudman, D.4
  • 49
    • 0020659196 scopus 로고
    • Alterations of peripheral blood lymphocyte cyclic AMP and cyclic GMP in untreated patients with hodgkin's disease
    • Aleksijevic, A., Lang, J.M., Giron, C., Stoclet, J.C., Mayer, S., Oberling, F. Alterations of peripheral blood lymphocyte cyclic AMP and cyclic GMP in untreated patients with hodgkin's disease. Clin. Immunol. Immunopathol. 1983, 26, 398-405.
    • (1983) Clin. Immunol. Immunopathol , vol.26 , pp. 398-405
    • Aleksijevic, A.1    Lang, J.M.2    Giron, C.3    Stoclet, J.C.4    Mayer, S.5    Oberling, F.6
  • 52
    • 0027499522 scopus 로고
    • Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes
    • Ciardiello, F., Pepe, S., Bianco, C., Baldassarre, G., Ruggiero, A., Bianco, C., Selvam, M.P., Bianco, A.R., Tortora, G. Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes. Int. J. Cancer 1993, 53, 438-443.
    • (1993) Int. J. Cancer , vol.53 , pp. 438-443
    • Ciardiello, F.1    Pepe, S.2    Bianco, C.3    Baldassarre, G.4    Ruggiero, A.5    Bianco, C.6    Selvam, M.P.7    Bianco, A.R.8    Tortora, G.9
  • 53
    • 0017030719 scopus 로고
    • Sequential alterations in the hepatic content and metabolism of cyclic AMP and cyclic GMP induced by DL-ethionine: Evidence for malignant transformation of liver with a sustained increase in cyclic AMP
    • DeRubertis, F.R., Craven, P.A. Sequential alterations in the hepatic content and metabolism of cyclic AMP and cyclic GMP induced by DL-ethionine: Evidence for malignant transformation of liver with a sustained increase in cyclic AMP. Metabolism 1976, 25, 1611-1625.
    • (1976) Metabolism , vol.25 , pp. 1611-1625
    • Derubertis, F.R.1    Craven, P.A.2
  • 54
    • 0023889815 scopus 로고
    • Prostanoids and cyclic nucleotides in malignant and benign ovarian tumors
    • Heinonen, P.K., Metsa-Ketela, T. Prostanoids and cyclic nucleotides in malignant and benign ovarian tumors. Med. Oncol. Tumor Pharmacother. 1988, 5, 11-15.
    • (1988) Med. Oncol. Tumor Pharmacother , vol.5 , pp. 11-15
    • Heinonen, P.K.1    Metsa-Ketela, T.2
  • 55
    • 71049194270 scopus 로고    scopus 로고
    • Signalling pathway alterations in pituitary adenomas: Involvement of Gsalpha, cAMP and mitogen-activated protein kinases
    • Pertuit, M., Barlier, A., Enjalbert, A., Gérard, C. Signalling pathway alterations in pituitary adenomas: Involvement of Gsalpha, cAMP and mitogen-activated protein kinases. J. Neuroendocrinol. 2009, 21, 869-877.
    • (2009) J. Neuroendocrinol , vol.21 , pp. 869-877
    • Pertuit, M.1    Barlier, A.2    Enjalbert, A.3    Gérard, C.4
  • 56
    • 19644394294 scopus 로고    scopus 로고
    • 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells
    • Ahn, Y.H., Jung, J.M., Hong, S.H. 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res. 2005, 65, 4896-4901.
    • (2005) Cancer Res , vol.65 , pp. 4896-4901
    • Ahn, Y.H.1    Jung, J.M.2    Hong, S.H.3
  • 58
    • 84881444195 scopus 로고    scopus 로고
    • Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: Implications for intervention
    • Schuller, H.M. Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: Implications for intervention. Cancer Biomark. 2013, 13, 133-144.
    • (2013) Cancer Biomark , vol.13 , pp. 133-144
    • Schuller, H.M.1
  • 60
    • 18444366205 scopus 로고    scopus 로고
    • Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells
    • Zhu, B., Vemavarapu, L., Thompson, W.J., Strada, S.J. Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. J. Cell. Biochem. 2005, 94, 336-350.
    • (2005) J. Cell. Biochem , vol.94 , pp. 336-350
    • Zhu, B.1    Vemavarapu, L.2    Thompson, W.J.3    Strada, S.J.4
  • 61
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • Kool, M., de Haas, M., Scheffer, G.L., Scheper, R.J., van Eijk, M.J., Juijn, J.A., Baas, F., Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 1997, 57, 3537-3547.
    • (1997) Cancer Res , vol.57 , pp. 3537-3547
    • Kool, M.1    de Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    van Eijk, M.J.5    Juijn, J.A.6    Baas, F.7    Borst, P.8
  • 62
    • 0017229843 scopus 로고
    • Cyclic nucleotide phosphodiesterases in neoplastic and nonneoplastic human mammary tissues
    • Singer, A.L., Sherwin, R.P., Dunn, A.S., Appleman, M.M. Cyclic nucleotide phosphodiesterases in neoplastic and nonneoplastic human mammary tissues. Cancer Res. 1976, 36, 60-66.
    • (1976) Cancer Res , vol.36 , pp. 60-66
    • Singer, A.L.1    Sherwin, R.P.2    Dunn, A.S.3    Appleman, M.M.4
  • 63
    • 0017071490 scopus 로고
    • Cyclic nucleotide phosphodiesterase activity in normal and neoplastic rat mammary cells grown in monolayer culture
    • Cohen, L.A., Straka, D., Chan, P.C. Cyclic nucleotide phosphodiesterase activity in normal and neoplastic rat mammary cells grown in monolayer culture. Cancer Res. 1976, 36, 2007-2012.
    • (1976) Cancer Res , vol.36 , pp. 2007-2012
    • Cohen, L.A.1    Straka, D.2    Chan, P.C.3
  • 64
    • 73149104650 scopus 로고    scopus 로고
    • Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G
    • Tinsley, H.N., Gary, B.D., Keeton, A.B., Zhang, W., Abadi, A.H., Reynolds, R.C., Piazza, G.A. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol. Cancer Ther. 2009, 8, 3331-3340.
    • (2009) Mol. Cancer Ther , vol.8 , pp. 3331-3340
    • Tinsley, H.N.1    Gary, B.D.2    Keeton, A.B.3    Zhang, W.4    Abadi, A.H.5    Reynolds, R.C.6    Piazza, G.A.7
  • 67
    • 0033783798 scopus 로고    scopus 로고
    • Cyclic 3',5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy
    • Marko, D., Pahlke, G., Merz, K.H., Eisenbrand, G. Cyclic 3',5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy. Chem. Res. Toxicol. 2000, 13, 944-948.
    • (2000) Chem. Res. Toxicol , vol.13 , pp. 944-948
    • Marko, D.1    Pahlke, G.2    Merz, K.H.3    Eisenbrand, G.4
  • 68
    • 39449136774 scopus 로고    scopus 로고
    • Cyclic nucleotide-regulated proliferation and differentiation vary in human hematopoietic progenitor cells derived from healthy persons, tumor patients, and chronic myelocytic leukemia patients
    • Kobsar, A., Heeg, S., Krohne, K., Opitz, A., Walter, U., Böck, M., Gambaryan, S., Eigenthaler, M. Cyclic nucleotide-regulated proliferation and differentiation vary in human hematopoietic progenitor cells derived from healthy persons, tumor patients, and chronic myelocytic leukemia patients. Stem Cells Dev. 2008, 17, 81-91.
    • (2008) Stem Cells Dev , vol.17 , pp. 81-91
    • Kobsar, A.1    Heeg, S.2    Krohne, K.3    Opitz, A.4    Walter, U.5    Böck, M.6    Gambaryan, S.7    Eigenthaler, M.8
  • 69
    • 0028803824 scopus 로고
    • Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line
    • Kiefer, J., Okret, S., Jondal, M., McConkey, D.J. Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line. J. Immunol. 1995, 155, 4525-4528.
    • (1995) J. Immunol , vol.155 , pp. 4525-4528
    • Kiefer, J.1    Okret, S.2    Jondal, M.3    McConkey, D.J.4
  • 70
    • 0032439927 scopus 로고    scopus 로고
    • Effects of granulocyte-macrophage colony-stimulating factor and cyclic AMP interaction on human neutrophil apoptosis
    • Tortorella, C., Piazzolla, G., Spaccavento, F., Antonaci, S. Effects of granulocyte-macrophage colony-stimulating factor and cyclic AMP interaction on human neutrophil apoptosis. Mediat. Inflamm. 1998, 7, 391-396.
    • (1998) Mediat. Inflamm , vol.7 , pp. 391-396
    • Tortorella, C.1    Piazzolla, G.2    Spaccavento, F.3    Antonaci, S.4
  • 71
    • 0035976930 scopus 로고    scopus 로고
    • Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway
    • Martin, M.C., Dransfield, I., Haslett, C., Rossi, A.G. Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway. J. Biol. Chem. 2001, 276, 45041-45050.
    • (2001) J. Biol. Chem , vol.276 , pp. 45041-45050
    • Martin, M.C.1    Dransfield, I.2    Haslett, C.3    Rossi, A.G.4
  • 72
    • 2642697857 scopus 로고    scopus 로고
    • cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells
    • Garcia-Bermejo, L., Pérez, C., Vilaboa, N.E., de Blas, E., Aller, P. cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells. J. Cell Sci. 1998, 111, 637-644.
    • (1998) J. Cell Sci , vol.111 , pp. 637-644
    • Garcia-Bermejo, L.1    Pérez, C.2    Vilaboa, N.E.3    de Blas, E.4    Aller, P.5
  • 73
    • 0016702719 scopus 로고
    • Cyclic adenosine 3':5'-monophosphate levels and activities of related enzymes in normal and leukemic lymphocytes
    • Monahan, T.M., Marchand, N.W., Fritz, R.R., Abell, C.W. Cyclic adenosine 3':5'-monophosphate levels and activities of related enzymes in normal and leukemic lymphocytes. Cancer Res. 1975, 35, 2540-2547.
    • (1975) Cancer Res , vol.35 , pp. 2540-2547
    • Monahan, T.M.1    Marchand, N.W.2    Fritz, R.R.3    Abell, C.W.4
  • 74
    • 0019300211 scopus 로고
    • Observations on the level of cyclic nucleotides in three population of human lymphocytes in culture
    • Carpentieri, U., Monahan, T.M., Gustavson, L.P. Observations on the level of cyclic nucleotides in three population of human lymphocytes in culture. J. Cycl. Nucleotide Res. 1980, 6, 253-259.
    • (1980) J. Cycl. Nucleotide Res , vol.6 , pp. 253-259
    • Carpentieri, U.1    Monahan, T.M.2    Gustavson, L.P.3
  • 75
    • 0036151438 scopus 로고    scopus 로고
    • PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP
    • Lee, R., Wolda, S., Moon, E., Esselstyn, J., Hertel, C., Lerner, A. PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cell. Signal. 2002, 14, 277-284.
    • (2002) Cell. Signal , vol.14 , pp. 277-284
    • Lee, R.1    Wolda, S.2    Moon, E.3    Esselstyn, J.4    Hertel, C.5    Lerner, A.6
  • 76
    • 0035427498 scopus 로고    scopus 로고
    • Control of survival of proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators
    • Flamigni, F., Facchini, A., Stanic, I., Tantini, B., Bonavita, F., Stefanelli, C. Control of survival of proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators. Biochem. Pharmacol. 2001, 62, 319-328.
    • (2001) Biochem. Pharmacol , vol.62 , pp. 319-328
    • Flamigni, F.1    Facchini, A.2    Stanic, I.3    Tantini, B.4    Bonavita, F.5    Stefanelli, C.6
  • 78
    • 38949115909 scopus 로고    scopus 로고
    • Guanylin peptides and colorectal cancer (CRC)
    • Camici, M. Guanylin peptides and colorectal cancer (CRC). Biomed. Pharmacother. 2008, 62, 70-76.
    • (2008) Biomed. Pharmacother , vol.62 , pp. 70-76
    • Camici, M.1
  • 79
    • 14644392242 scopus 로고    scopus 로고
    • Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract
    • Birbe, R., Palazzo, J.P., Walters, R., Weinberg, D., Schulz, S., Waldman, S.A. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum. Pathol. 2005, 36, 170-179.
    • (2005) Hum. Pathol , vol.36 , pp. 170-179
    • Birbe, R.1    Palazzo, J.P.2    Walters, R.3    Weinberg, D.4    Schulz, S.5    Waldman, S.A.6
  • 80
    • 0036898023 scopus 로고    scopus 로고
    • Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation
    • Steinbrecher, K.A., Wowk, S.A., Rudolph, J.A., Witte, D.P., Cohen, M.B. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am. J. Pathol. 2002, 161, 2169-2178.
    • (2002) Am. J. Pathol , vol.161 , pp. 2169-2178
    • Steinbrecher, K.A.1    Wowk, S.A.2    Rudolph, J.A.3    Witte, D.P.4    Cohen, M.B.5
  • 82
    • 0345701291 scopus 로고    scopus 로고
    • Bacterial enterotoxins are associated with resistance to colon cancer
    • Pitari, G.M., Zingman, L.V., Waldman, S.A. Bacterial enterotoxins are associated with resistance to colon cancer. Proc. Natl. Acad. Sci. USA 2003, 100, 2695-2699.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2695-2699
    • Pitari, G.M.1    Zingman, L.V.2    Waldman, S.A.3
  • 83
    • 9244262423 scopus 로고    scopus 로고
    • The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
    • Johansson, C.C., Yndestad, A., Enserink, J.M., Ree, A.H., Aukrust, P., Taskén, K. The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. Endocrinology 2004, 145, 5177-5184.
    • (2004) Endocrinology , vol.145 , pp. 5177-5184
    • Johansson, C.C.1    Yndestad, A.2    Enserink, J.M.3    Ree, A.H.4    Aukrust, P.5    Taskén, K.6
  • 84
    • 0017761023 scopus 로고
    • Altered levels of cyclic nucleotides, cyclic AMP phosphodiesterase and adenylyl cyclase activities in normal, dysplastic and neoplastic human mammary tissue
    • Kung, W., Bechtel, E., Geyer, E., Salokangas, A., Preisz, J., Huber, P., Torhorst, J., Jungmann, R.A., Talmadge, K., Eppenberger, U. Altered levels of cyclic nucleotides, cyclic AMP phosphodiesterase and adenylyl cyclase activities in normal, dysplastic and neoplastic human mammary tissue. FEBS Lett. 1977, 82, 102-106.
    • (1977) FEBS Lett , vol.82 , pp. 102-106
    • Kung, W.1    Bechtel, E.2    Geyer, E.3    Salokangas, A.4    Preisz, J.5    Huber, P.6    Torhorst, J.7    Jungmann, R.A.8    Talmadge, K.9    Eppenberger, U.10
  • 86
    • 0034730755 scopus 로고    scopus 로고
    • The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
    • Jedlitschky, G., Burchell, B., Keppler, D. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J. Biol. Chem. 2000, 275, 30069-30074.
    • (2000) J. Biol. Chem , vol.275 , pp. 30069-30074
    • Jedlitschky, G.1    Burchell, B.2    Keppler, D.3
  • 87
    • 69249216479 scopus 로고    scopus 로고
    • EPAC proteins transduce diverse cellular actions of cAMP
    • Borland, G., Smith, B.O., Yarwood, S.J. EPAC proteins transduce diverse cellular actions of cAMP. Br. J. Pharmacol. 2009, 158, 70-86.
    • (2009) Br. J. Pharmacol , vol.158 , pp. 70-86
    • Borland, G.1    Smith, B.O.2    Yarwood, S.J.3
  • 88
    • 38349041719 scopus 로고    scopus 로고
    • Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine
    • Li, P., Lin, J.E., Chervoneva, I., Schulz, S., Waldman, S.A., Pitari, G.M. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am. J. Pathol. 2007, 171, 1847-1858.
    • (2007) Am. J. Pathol , vol.171 , pp. 1847-1858
    • Li, P.1    Lin, J.E.2    Chervoneva, I.3    Schulz, S.4    Waldman, S.A.5    Pitari, G.M.6
  • 89
    • 0034933794 scopus 로고    scopus 로고
    • Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    • Pitari, G.M., di Guglielmo, M.D., Park, J., Schulz, S., Waldman, S.A. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc. Natl. Acad. Sci. USA 2001, 98, 7846-7851.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7846-7851
    • Pitari, G.M.1    di Guglielmo, M.D.2    Park, J.3    Schulz, S.4    Waldman, S.A.5
  • 90
    • 23244450076 scopus 로고    scopus 로고
    • Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
    • Mann, E.A., Steinbrecher, K.A., Stroup, C., Witte, D.P., Cohen, M.B., Giannella, R.A. Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. Int. J. Cancer 2005, 116, 500-505.
    • (2005) Int. J. Cancer , vol.116 , pp. 500-505
    • Mann, E.A.1    Steinbrecher, K.A.2    Stroup, C.3    Witte, D.P.4    Cohen, M.B.5    Giannella, R.A.6
  • 91
    • 31144433061 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
    • Lugnier, C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol. Ther. 2006, 109, 366-398.
    • (2006) Pharmacol. Ther , vol.109 , pp. 366-398
    • Lugnier, C.1
  • 92
    • 0029417330 scopus 로고
    • 2+ responses are differentially modulated by nitric oxide via activation of a cyclic GMP-dependent pathway
    • 2+ responses are differentially modulated by nitric oxide via activation of a cyclic GMP-dependent pathway. Mol. Pharmacol. 1995, 48, 1068-1077.
    • (1995) Mol. Pharmacol , vol.48 , pp. 1068-1077
    • Clementi, E.1    Sciorati, C.2    Nistico, G.3
  • 94
    • 42949095659 scopus 로고    scopus 로고
    • Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium
    • Chen, H., Levine, Y.C., Golan, D.E., Michel, T., Lin, A.J. Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium. J. Biol. Chem. 2008, 283, 4439-4447.
    • (2008) J. Biol. Chem , vol.283 , pp. 4439-4447
    • Chen, H.1    Levine, Y.C.2    Golan, D.E.3    Michel, T.4    Lin, A.J.5
  • 95
    • 0033515490 scopus 로고    scopus 로고
    • Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase
    • Idriss, S.D., Gudi, T., Casteel, D.E., Kharitonov, V.G., Pilz, R.B., Boss, G.R. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J. Biol. Chem. 1999, 274, 9489-9493.
    • (1999) J. Biol. Chem , vol.274 , pp. 9489-9493
    • Idriss, S.D.1    Gudi, T.2    Casteel, D.E.3    Kharitonov, V.G.4    Pilz, R.B.5    Boss, G.R.6
  • 96
    • 0344011964 scopus 로고    scopus 로고
    • Regulation of gene expression by cyclic GMP
    • Pilz, R.B., Casteel, D.E. Regulation of gene expression by cyclic GMP. Circ. Res. 2003, 93, 1034-1046.
    • (2003) Circ. Res , vol.93 , pp. 1034-1046
    • Pilz, R.B.1    Casteel, D.E.2
  • 97
    • 84866480918 scopus 로고    scopus 로고
    • Cyclic GMP/protein kinase G type-Ialpha (PKG-Ialpha) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Ialpha kinase activity synergizes with cisplatin in non-small cell lung cancer cells
    • Wong, J.C., Bathina, M., Fiscus, R.R. Cyclic GMP/protein kinase G type-Ialpha (PKG-Ialpha) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Ialpha kinase activity synergizes with cisplatin in non-small cell lung cancer cells. J. Cell. Biochem. 2012, 113, 3587-3598.
    • (2012) J. Cell. Biochem , vol.113 , pp. 3587-3598
    • Wong, J.C.1    Bathina, M.2    Fiscus, R.R.3
  • 98
    • 84878662606 scopus 로고    scopus 로고
    • cGMP-dependent protein kinase Ibeta interacts with p44/WDR77 to regulate androgen receptor-driven gene expression
    • Zhou, L., Hosohata, K., Gao, S., Gu, Z., Wang, Z. cGMP-dependent protein kinase Ibeta interacts with p44/WDR77 to regulate androgen receptor-driven gene expression. PLoS One 2013, 8, e63119.
    • (2013) PLoS One , vol.8
    • Zhou, L.1    Hosohata, K.2    Gao, S.3    Gu, Z.4    Wang, Z.5
  • 99
    • 84860785586 scopus 로고    scopus 로고
    • cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells
    • Lan, T., Chen, Y., Sang, J., Wu, Y., Wang, Y., Jiang, L., Tao, Y. Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells. Oncol. Rep. 2012, 27, 2039-2044.
    • (2012) Oncol. Rep , vol.27 , pp. 2039-2044
    • Lan, T.1    Chen, Y.2    Sang, J.3    Wu, Y.4    Wang, Y.5    Jiang, L.6    Tao, Y.7    Type, I.I.8
  • 101
    • 2342652901 scopus 로고
    • Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells
    • Seamon, K.B., Padgett, W., Daly, J.W. Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA 1981, 78, 3363-3367.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 3363-3367
    • Seamon, K.B.1    Padgett, W.2    Daly, J.W.3
  • 102
    • 0021083279 scopus 로고
    • Forskolin: A potential antimetastatic agent
    • Agarwal, K.C., Parks, R.E., Jr. Forskolin: A potential antimetastatic agent. Int. J. Cancer 1983, 32, 801-804.
    • (1983) Int. J. Cancer , vol.32 , pp. 801-804
    • Agarwal, K.C.1    Parks Jr., R.E.2
  • 103
    • 0031892108 scopus 로고    scopus 로고
    • Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas
    • Chen, T.C., Hinton, D.R., Zidovetzki, R., Hofman, F.M. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Investig. 1998, 78, 165-174.
    • (1998) Lab. Investig , vol.78 , pp. 165-174
    • Chen, T.C.1    Hinton, D.R.2    Zidovetzki, R.3    Hofman, F.M.4
  • 104
    • 33750332011 scopus 로고    scopus 로고
    • A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release
    • Li, Z., Wang, J. A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Cell Biol. Int. 2006, 30, 940-946.
    • (2006) Cell Biol. Int , vol.30 , pp. 940-946
    • Li, Z.1    Wang, J.2
  • 106
    • 0025281884 scopus 로고
    • Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy-A comparative study with dobutamine and sodium nitroprusside
    • Baumann, G., Felix, S., Sattelberger, U., Klein, G. Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy-A comparative study with dobutamine and sodium nitroprusside. J. Cardiovasc. Pharmacol. 1990, 16, 93-100.
    • (1990) J. Cardiovasc. Pharmacol , vol.16 , pp. 93-100
    • Baumann, G.1    Felix, S.2    Sattelberger, U.3    Klein, G.4
  • 107
    • 0028800664 scopus 로고
    • The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release
    • Christenson, J.T., Thulesius, O., Nazzal, M.M. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995, 24, 56-61.
    • (1995) Vasa , vol.24 , pp. 56-61
    • Christenson, J.T.1    Thulesius, O.2    Nazzal, M.M.3
  • 108
    • 13244291443 scopus 로고    scopus 로고
    • Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase a signal transduction pathway
    • Ding, X., Staudinger, J.L. Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase a signal transduction pathway. J. Pharmacol. Exp. Ther. 2005, 312, 849-856.
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 849-856
    • Ding, X.1    Staudinger, J.L.2
  • 109
    • 84864420773 scopus 로고    scopus 로고
    • Beta-adrenergic blocking drugs in breast cancer: A perspective review
    • Barron, T.I., Sharp, L., Visvanathan, K. Beta-adrenergic blocking drugs in breast cancer: A perspective review. Ther. Adv. Med. Oncol. 2012, 4, 113-125.
    • (2012) Ther. Adv. Med. Oncol , vol.4 , pp. 113-125
    • Barron, T.I.1    Sharp, L.2    Visvanathan, K.3
  • 110
    • 79960133993 scopus 로고    scopus 로고
    • Expanding our therapeutic options: Beta blockers for breast cancer
    • Ganz, P.A., Cole, S.W. Expanding our therapeutic options: Beta blockers for breast cancer? J. Clin. Oncol. 2011, 29, 2612-2616.
    • (2011) J. Clin. Oncol , vol.29 , pp. 2612-2616
    • Ganz, P.A.1    Cole, S.W.2
  • 111
    • 84863905604 scopus 로고    scopus 로고
    • Beta blockers, norepinephrine, and cancer: An epidemiological viewpoint
    • Fitzgerald, P.J. Beta blockers, norepinephrine, and cancer: An epidemiological viewpoint. Clin. Epidemiol. 2012, 4, 151-156.
    • (2012) Clin. Epidemiol , vol.4 , pp. 151-156
    • Fitzgerald, P.J.1
  • 112
    • 84877125671 scopus 로고    scopus 로고
    • Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy
    • Wang, H.M., Liao, Z.X., Komaki, R., Welsh, J.W., O'Reilly, M.S., Chang, J.Y., Zhuang, Y., Levy, L.B., Lu, C., Gomez, D.R. Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. Ann. Oncol. 2013, 24, 1312-1319.
    • (2013) Ann. Oncol , vol.24 , pp. 1312-1319
    • Wang, H.M.1    Liao, Z.X.2    Komaki, R.3    Welsh, J.W.4    O'Reilly, M.S.5    Chang, J.Y.6    Zhuang, Y.7    Levy, L.B.8    Lu, C.9    Gomez, D.R.10
  • 113
    • 0024309624 scopus 로고
    • Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators
    • Garg, U.C., Hassid, A. Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators. Am. J. Physiol. 1989, 257, F60-F66.
    • (1989) Am. J. Physiol , vol.257
    • Garg, U.C.1    Hassid, A.2
  • 114
    • 0025005519 scopus 로고
    • Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism
    • Garg, U.C., Hassid, A. Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism. Biochem. Biophys. Res. Commun. 1990, 171, 474-479.
    • (1990) Biochem. Biophys. Res. Commun , vol.171 , pp. 474-479
    • Garg, U.C.1    Hassid, A.2
  • 115
    • 0034646652 scopus 로고    scopus 로고
    • Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k)
    • Gu, M., Lynch, J., Brecher, P. Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k). J. Biol. Chem. 2000, 275, 11389-11396.
    • (2000) J. Biol. Chem , vol.275 , pp. 11389-11396
    • Gu, M.1    Lynch, J.2    Brecher, P.3
  • 116
    • 54349129548 scopus 로고    scopus 로고
    • Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
    • Hagos, G.K., Abdul-Hay, S.O., Sohn, J., Edirisinghe, P.D., Chandrasena, R.E., Wang, Z., Li, Q., Thatcher, G.R. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Mol. Pharmacol. 2008, 74, 1381-1391.
    • (2008) Mol. Pharmacol , vol.74 , pp. 1381-1391
    • Hagos, G.K.1    Abdul-Hay, S.O.2    Sohn, J.3    Edirisinghe, P.D.4    Chandrasena, R.E.5    Wang, Z.6    Li, Q.7    Thatcher, G.R.8
  • 117
    • 47049091866 scopus 로고    scopus 로고
    • NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action
    • Rigas, B., Williams, J.L. NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action. Nitric Oxide 2008, 19, 199-204.
    • (2008) Nitric Oxide , vol.19 , pp. 199-204
    • Rigas, B.1    Williams, J.L.2
  • 118
    • 77749343038 scopus 로고    scopus 로고
    • Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract
    • Sostres, C., Gargallo, C.J., Arroyo, M.T., Lanas, A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract. Res. Clin. Gastroenterol. 2010, 24, 121-132.
    • (2010) Best Pract. Res. Clin. Gastroenterol , vol.24 , pp. 121-132
    • Sostres, C.1    Gargallo, C.J.2    Arroyo, M.T.3    Lanas, A.4
  • 119
    • 33745817069 scopus 로고    scopus 로고
    • Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo
    • Shami, P.J., Saavedra, J.E., Bonifant, C.L., Chu, J., Udupi, V., Malaviya, S., Carr, B.I., Kar, S., Wang, M., Jia, L., et al. Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo. J. Med. Chem. 2006, 49, 4356-4366.
    • (2006) J. Med. Chem , vol.49 , pp. 4356-4366
    • Shami, P.J.1    Saavedra, J.E.2    Bonifant, C.L.3    Chu, J.4    Udupi, V.5    Malaviya, S.6    Carr, B.I.7    Kar, S.8    Wang, M.9    Jia, L.10
  • 120
    • 3342991544 scopus 로고    scopus 로고
    • Potency, selectivity, and consequences of nonselectivity of PDE inhibition
    • Bischoff, E. Potency, selectivity, and consequences of nonselectivity of PDE inhibition. Int. J. Impot. Res. 2004, 16, S11-S14.
    • (2004) Int. J. Impot. Res , vol.16
    • Bischoff, E.1
  • 121
    • 80051525438 scopus 로고    scopus 로고
    • Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-cateninmediated transcription in human breast tumor cells
    • Tinsley, H.N., Gary, B.D., Keeton, A.B., Lu, W.Y., Li, Y.H., Piazza, G.A. Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/beta-cateninmediated transcription in human breast tumor cells. Cancer Prev. Res. (Phila.) 2011, 4, 1275-1284.
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 1275-1284
    • Tinsley, H.N.1    Gary, B.D.2    Keeton, A.B.3    Lu, W.Y.4    Li, Y.H.5    Piazza, G.A.6
  • 122
    • 77958542617 scopus 로고    scopus 로고
    • Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition
    • Tinsley, H.N., Gary, B.D., Thaiparambil, J., Li, N., Lu, W., Li, Y., Maxuitenko, Y.Y., Keeton, A.B., Piazza, G.A. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. Cancer Prev. Res. (Phila.) 2010, 3, 1303-1313.
    • (2010) Cancer Prev. Res. (Phila.) , vol.3 , pp. 1303-1313
    • Tinsley, H.N.1    Gary, B.D.2    Thaiparambil, J.3    Li, N.4    Lu, W.5    Li, Y.6    Maxuitenko, Y.Y.7    Keeton, A.B.8    Piazza, G.A.9
  • 124
    • 73249143661 scopus 로고    scopus 로고
    • Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB
    • Erikstein, B.S., McCormack, E., Tronstad, K.J., Schwede, F., Berge, R., Gjertsen, B.T. Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. Leuk. Res. 2010, 34, 77-84.
    • (2010) Leuk. Res , vol.34 , pp. 77-84
    • Erikstein, B.S.1    McCormack, E.2    Tronstad, K.J.3    Schwede, F.4    Berge, R.5    Gjertsen, B.T.6
  • 126
    • 77952775652 scopus 로고    scopus 로고
    • 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells
    • Bouizar, Z., Ragazzon, B., Viou, L., Hortane, M., Bertherat, J., Rizk-Rabin, M. 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells. J. Mol. Endocrinol. 2010, 44, 331-347.
    • (2010) J. Mol. Endocrinol , vol.44 , pp. 331-347
    • Bouizar, Z.1    Ragazzon, B.2    Viou, L.3    Hortane, M.4    Bertherat, J.5    Rizk-Rabin, M.6
  • 127
    • 48549098685 scopus 로고    scopus 로고
    • Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1
    • Cen, B., Deguchi, A., Weinstein, I.B. Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res. 2008, 68, 5355-5362.
    • (2008) Cancer Res , vol.68 , pp. 5355-5362
    • Cen, B.1    Deguchi, A.2    Weinstein, I.B.3
  • 128
    • 41149096647 scopus 로고    scopus 로고
    • Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis
    • Kwon, I.K., Schoenlein, P.V., Delk, J., Liu, K., Thangaraju, M., Dulin, N.O., Ganapathy, V., Berger, F.G., Browning, D.D. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer 2008, 112, 1462-1470.
    • (2008) Cancer , vol.112 , pp. 1462-1470
    • Kwon, I.K.1    Schoenlein, P.V.2    Delk, J.3    Liu, K.4    Thangaraju, M.5    Dulin, N.O.6    Ganapathy, V.7    Berger, F.G.8    Browning, D.D.9
  • 130
    • 45949102420 scopus 로고    scopus 로고
    • Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G
    • Soh, J.W., Kazi, J.U., Li, H., Thompson, W.J., Weinstein, I.B. Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. Mol. Carcinog. 2008, 47, 519-525.
    • (2008) Mol. Carcinog , vol.47 , pp. 519-525
    • Soh, J.W.1    Kazi, J.U.2    Li, H.3    Thompson, W.J.4    Weinstein, I.B.5
  • 131
    • 80052441173 scopus 로고    scopus 로고
    • Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines
    • Fallahian, F., Karami-Tehrani, F., Salami, S., Aghaei, M. Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines. FEBS J. 2011, 278, 3360-3369.
    • (2011) FEBS J , vol.278 , pp. 3360-3369
    • Fallahian, F.1    Karami-Tehrani, F.2    Salami, S.3    Aghaei, M.4
  • 133
    • 76249089855 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
    • Edwards, B.K., Ward, E., Kohler, B.A., Eheman, C., Zauber, A.G., Anderson, R.N., Jemal, A., Schymura, M.J., Lansdorp-Vogelaar, I., Seeff, L.C., et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 2010, 116, 544-573.
    • (2010) Cancer , vol.116 , pp. 544-573
    • Edwards, B.K.1    Ward, E.2    Kohler, B.A.3    Eheman, C.4    Zauber, A.G.5    Anderson, R.N.6    Jemal, A.7    Schymura, M.J.8    Lansdorp-Vogelaar, I.9    Seeff, L.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.