Cyclic 3',5'-nucleotide phosphodiesterases: Potential targets for anticancer therapy

Chemical Research in Toxicology

Volumn 13, Issue 10, 2000, Pages 944-948

  Marko, D ^a   Pahlke, G ^a   Merz, K H ^a   Eisenbrand, G ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CYCLIC AMP; SCH 51866;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CONFERENCE PAPER; DNA FLANKING REGION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE INACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; REPORTER GENE; SIGNAL TRANSDUCTION; TARGET CELL; TUMOR CELL CULTURE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; HUMANS; NEOPLASMS;

EID: 0033783798     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000090l     Document Type: Conference Paper

References (11)

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4. Combined in vitro/in vivo test procedure with human tumor xenografts for new drug development
5. The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation
6. c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy
7. 3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition
8. Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth
9. Inhibition by cAMP of rasdependent activation of Raf
10. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate
11. Subcellular localization of a pteridine-based inhibitor of cyclic adenosine monophosphate specific phosphodiesterase