Cyclic GMP/protein kinase G type-Iα (PKG-Iα) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Iα kinase activity synergizes with cisplatin in non-small cell lung cancer cells

Journal of Cellular Biochemistry

Volumn 113, Issue 11, 2012, Pages 3587-3598

  Wong, Janica C ^a,b,c   Bathina, Madhavi ^c   Fiscus, Ronald R ^a,c  

^a ROSEMAN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NEVADA   (United States)

^c NEVADA CANCER INSTITUTE   (United States)

Author keywords

APOPTOSIS; cAMP RESPONSIVE ELEMENT BINDING PROTEIN; CISPLATIN; CYCLIC GMP; INHIBITOR OF APOPTOSIS PROTEINS; NON SMALL CELL LUNG CANCER; PROTEIN KINASE G

Indexed keywords

BCL2 RELATED PROTEIN A1; CYCLIC AMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; LIVIN; PROTEIN MCL 1; SERINE; SURVIVIN;

APOPTOSIS; ARTICLE; CANCER CELL; COLONY FORMING CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CISPLATIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LUNG NEOPLASMS; NEOPLASM PROTEINS; OXADIAZOLES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOXALINES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

INTRACISTERNAL A-PARTICLES;

EID: 84866480918     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24237     Document Type: Article

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