High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells

Oncogene

Volumn 27, Issue 13, 2008, Pages 1834-1843

  Mantovani, G ^a   Bondioni, S ^a   Lania, A G ^a   Rodolfo, M ^b   Peverelli, E ^a   Polentarutti, N ^c   Veliz Rodriguez, T ^c   Ferrero, S ^d   Bosari, S ^d   Beck Peccoz, P ^a   Spada, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

cAMP; Melanomas; PKA; Proliferation; R1 R2 ratio

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; CASPASE 3; CISPLATIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE A 1A; PROTEIN KINASE A 2B; PROTEIN P53; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VINBLASTINE;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIBETA SUBUNIT; HUMANS; IMMUNOENZYME TECHNIQUES; MELANOCYTES; MELANOMA; MIDDLE AGED; TUMOR CELLS, CULTURED;

EID: 41149123928     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210831     Document Type: Article

References (25)

1. Cho YS, Park YG, Lee YN, Kim MK, Bates S, Tan L et al. (2000). Extracellular proteinkinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression. Proc Nat Acad Sci USA 97: 835-840.
2. Cho-Chung YS, Nesterova MV. (2005). Tumor reversion: protein kinase A isozyme switching. Ann NY Acad Sci 1058: 76-86.
3. Cho-Chung YS, Pepe S, Clair T, Budillon A, Nesterova M. (1995). cAMP-dependent protein kinase: role in normal and malignant growth. Crit Rev Oncol Hematol 21: 2133-2161.
4. Cho-Chung YS. (1990). Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy. Cancer Res 50: 7093-7100.
5. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H et al. (2005). Distinct sets of genetic alterations in melanoma. N Engl J Med 353: 2135-2147.
6. Daniotti M, Oggionni M, Ranzani T, Vallacchi V, Campi V, Di Stasi D et al. (2004). BRAF alterations are associated with complex mutational profiles in malignant melanoma. Oncogene 23: 5968-5977.
7. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417: 949-954.
8. De Luca M, Siegrist W, Bondanza S, Mathor M, Cancedda R, Eberle AN. (1993). Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. J Cell Sci 105: 1079-1084.
9. Di Stasi D, Vallacchi V, Campi V, Ranzani T, Daniotti M, Chiodini E et al. (2005). DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis. Int J Cancer 115: 224-230.
10. Dumaz N, Marais R. (2005). Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. FEBS J 272: 3491-3504.
11. Handschin JS, Eppenberger U. (1979). Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors. FEBS Lett 106: 301.
12. Hunt G, Donatien PD, Lunec J, Todd C, Kyne S, Thody AJ. (1994). Cultured human melanocytes respond to MSH peptides and ACTH. Pigment Cell Res 7: 217-221.
13. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS et al. (2000). Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 26: 89-92.
14. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. (1989). GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340: 692-696.
15. Lania A, Mantovani G, Spada A. (2001). G protein mutations in endocrine diseases. Eur J Endocrinol 145: 543-559.
16. Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E et al. (2004). Proliferation of transformed somatotroph cells related to low or absent expression of PKA regulatory subunit 1A protein. Cancer Res 64: 9193-9198.
17. Levine N, Sheftel SN, Eytan T, Dorr RT, Hadley ME, Weinrach JC et al. (1991). Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. J Am Med Assoc 266: 2730-2736.
18. Miller AJ, Mihm Jr MC. (2006). Melanoma. N Engl J Med 355: 51-65.
19. Nesterova M, Yokozaki H, McDuffie E, Cho-Chung YS. (1996). Overexpression of RII beta regulatory subunit of PKA in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta. Eur J Biochem 235: 486-494.
20. Rohlff C, Clair T, Cho-Chung YS. (1993). 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268: 5774-5782.
21. Schwede F, Christensen A, Liauw S, Hippe T, Kopperud R, Jastorff B et al. (2000). 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochem 39: 8803-8812.
22. Siddik ZH. (2003). Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22: 7265-7279.
23. Tanami H, Imoto I, Hirasawa A, Yuki Y, Sonoda I, Inoue J et al. (2004). Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene 23: 8796-8804.
24. Tortora G, Clair T, Cho-Chung YS. (1990). An antisense oligodeoxy-nucleotide targeted against the type RIIh regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. Proc Natl Acad Sci USA 87: 705-708.
25. Weinstein LS, Shenker A, Gejman P, Marino MJ, Friedman E, Spiegel AM. (1991). Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 325: 1688-1695.