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Volumn 5, Issue JAN, 2014, Pages

Emerging role of endosomal toll-like receptors in rheumatoid arthritis

Author keywords

Autoimmunity; Autoimmunity models; Endosomal toll like receptors; Inflammation; Rheumatoid arthritis; Therapeutics; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

EID: 84895524861     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00001     Document Type: Review
Times cited : (60)

References (81)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • doi:10.1038/nri1391
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol (2004) 4(7):499-511. doi:10.1038/nri1391.
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • doi:10.1074/jbc.M306793200
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2004) 279(9):7370-7. doi:10.1074/jbc.M306793200.
    • (2004) J Biol Chem , vol.279 , Issue.9 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6
  • 3
    • 67650502739 scopus 로고    scopus 로고
    • Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    • doi:10.1038/nm.1987
    • Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med (2009) 15(7):774-80. doi:10.1038/nm.1987.
    • (2009) Nat Med , vol.15 , Issue.7 , pp. 774-780
    • Midwood, K.1    Sacre, S.2    Piccinini, A.M.3    Inglis, J.4    Trebaul, A.5    Chan, E.6
  • 4
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • doi:10.1155/2010/672395
    • Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm (2010) 2010:672395. doi:10.1155/2010/672395.
    • (2010) Mediators Inflamm , vol.2010 , pp. 672395
    • Piccinini, A.M.1    Midwood, K.S.2
  • 5
    • 79953062340 scopus 로고    scopus 로고
    • Nucleic acid recognition by the innate immune system
    • doi:10.1146/annurev-immunol-031210-101340
    • Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic acid recognition by the innate immune system. Annu Rev Immunol (2011) 29:185-214. doi:10.1146/annurev-immunol-031210-101340.
    • (2011) Annu Rev Immunol , vol.29 , pp. 185-214
    • Barbalat, R.1    Ewald, S.E.2    Mouchess, M.L.3    Barton, G.M.4
  • 6
    • 84863129261 scopus 로고    scopus 로고
    • DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature
    • doi:10.1038/emboj.2011.441
    • Li Y, Berke IC, Modis Y. DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature. EMBO J (2012) 31(4):919-31. doi:10.1038/emboj.2011.441.
    • (2012) EMBO J , vol.31 , Issue.4 , pp. 919-931
    • Li, Y.1    Berke, I.C.2    Modis, Y.3
  • 7
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • doi:10.1016/j.jaci.2006.02.023
    • Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol (2006) 117(5):979-87. doi:10.1016/j.jaci.2006.02.023.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.5 , pp. 979-987
    • Kaisho, T.1    Akira, S.2
  • 8
    • 0030003058 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • doi:10.1016/S0092-8674(00)81109-5
    • Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell (1996) 85(3):307-10. doi:10.1016/S0092-8674(00)81109-5.
    • (1996) Cell , vol.85 , Issue.3 , pp. 307-310
    • Feldmann, M.1    Brennan, F.M.2    Maini, R.N.3
  • 9
    • 84865375172 scopus 로고    scopus 로고
    • Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction
    • doi:10.1016/j.jaut.2012.05.021
    • Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J Autoimmun (2012) 39(3):222-8. doi:10.1016/j.jaut.2012.05.021.
    • (2012) J Autoimmun , vol.39 , Issue.3 , pp. 222-228
    • Boissier, M.C.1    Semerano, L.2    Challal, S.3    Saidenberg-Kermanac'h, N.4    Falgarone, G.5
  • 10
    • 84878328732 scopus 로고    scopus 로고
    • MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
    • doi:10.1038/emm.2013.39
    • Lee DG, Woo JW, Kwok SK, Cho ML, Park SH. MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis. Exp Mol Med (2013) 45:e20. doi:10.1038/emm.2013.39.
    • (2013) Exp Mol Med , vol.45
    • Lee, D.G.1    Woo, J.W.2    Kwok, S.K.3    Cho, M.L.4    Park, S.H.5
  • 11
    • 84875590600 scopus 로고    scopus 로고
    • Targeting monocytes/macrophages in the treatment of rheumatoid arthritis
    • doi:10.1093/rheumatology/kes304
    • Davignon JL, Hayder M, Baron M, Boyer JF, Constantin A, Apparailly F, et al. Targeting monocytes/macrophages in the treatment of rheumatoid arthritis. Rheumatology (Oxford) (2013) 52(4):590-8. doi:10.1093/rheumatology/kes304.
    • (2013) Rheumatology (Oxford) , vol.52 , Issue.4 , pp. 590-598
    • Davignon, J.L.1    Hayder, M.2    Baron, M.3    Boyer, J.F.4    Constantin, A.5    Apparailly, F.6
  • 12
    • 0029036702 scopus 로고
    • Rheumatoid arthritis: status of drug therapies
    • Moncur C, Williams HJ. Rheumatoid arthritis: status of drug therapies. Phys Ther (1995) 75(6):511-25.
    • (1995) Phys Ther , vol.75 , Issue.6 , pp. 511-525
    • Moncur, C.1    Williams, H.J.2
  • 13
    • 0036584028 scopus 로고    scopus 로고
    • Development of anti-TNF therapy for rheumatoid arthritis
    • doi:10.1038/nri802
    • Feldmann M. Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol (2002) 2(5):364-71. doi:10.1038/nri802.
    • (2002) Nat Rev Immunol , vol.2 , Issue.5 , pp. 364-371
    • Feldmann, M.1
  • 14
    • 84874660169 scopus 로고    scopus 로고
    • The problem of choice: current biologic agents and future prospects in RA
    • doi:10.1038/nrrheum.2013.8
    • Choy EH, Kavanaugh AF, Jones SA. The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol (2013) 9(3):154-63. doi:10.1038/nrrheum.2013.8.
    • (2013) Nat Rev Rheumatol , vol.9 , Issue.3 , pp. 154-163
    • Choy, E.H.1    Kavanaugh, A.F.2    Jones, S.A.3
  • 15
    • 79958108824 scopus 로고    scopus 로고
    • Advances in rheumatology: new targeted therapeutics
    • doi:10.1186/1478-6354-13-S1-S5
    • Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther (2011) 13(Suppl 1):S5. doi:10.1186/1478-6354-13-S1-S5.
    • (2011) Arthritis Res Ther , vol.13 , Issue.SUPPL. 1
    • Tak, P.P.1    Kalden, J.R.2
  • 16
    • 64549161956 scopus 로고    scopus 로고
    • Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review
    • doi:10.1186/ar2666
    • Rubbert-Roth A, Finckh A. Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review. Arthritis Res Ther (2009) 11(Suppl 1):S1. doi:10.1186/ar2666.
    • (2009) Arthritis Res Ther , vol.11 , Issue.SUPPL. 1
    • Rubbert-Roth, A.1    Finckh, A.2
  • 17
    • 84857233786 scopus 로고    scopus 로고
    • Sustained inhibition of progressive joint damage with rituximab plus methotrexate in early active rheumatoid arthritis: 2-year results from the randomised controlled trial IMAGE
    • doi:10.1136/annrheumdis-2011-200170
    • Tak PP, Rigby W, Rubbert-Roth A, Peterfy C, van Vollenhoven RF, Stohl W, et al. Sustained inhibition of progressive joint damage with rituximab plus methotrexate in early active rheumatoid arthritis: 2-year results from the randomised controlled trial IMAGE. Ann Rheum Dis (2012) 71(3):351-7. doi:10.1136/annrheumdis-2011-200170.
    • (2012) Ann Rheum Dis , vol.71 , Issue.3 , pp. 351-357
    • Tak, P.P.1    Rigby, W.2    Rubbert-Roth, A.3    Peterfy, C.4    van Vollenhoven, R.F.5    Stohl, W.6
  • 19
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
    • doi:10.1136/ard.2008.092932
    • Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, Sanchez A, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis (2008) 67(11):1516-23. doi:10.1136/ard.2008.092932.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    van Vollenhoven, R.5    Sanchez, A.6
  • 20
    • 17244364098 scopus 로고    scopus 로고
    • Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study
    • doi:10.1002/art.20982
    • Smolen JS, Han C, Bala M, Maini RN, Kalden JR, van derHeijde D, et al. Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheum (2005) 52(4):1020-30. doi:10.1002/art.20982.
    • (2005) Arthritis Rheum , vol.52 , Issue.4 , pp. 1020-1030
    • Smolen, J.S.1    Han, C.2    Bala, M.3    Maini, R.N.4    Kalden, J.R.5    van derHeijde, D.6
  • 21
    • 84874422827 scopus 로고    scopus 로고
    • Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis
    • doi:10.1002/art.37797
    • Binder NB, Puchner A, Niederreiter B, Hayer S, Leiss H, Blüml S, et al. Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis. Arthritis Rheum (2013) 65(3):608-17. doi:10.1002/art.37797.
    • (2013) Arthritis Rheum , vol.65 , Issue.3 , pp. 608-617
    • Binder, N.B.1    Puchner, A.2    Niederreiter, B.3    Hayer, S.4    Leiss, H.5    Blüml, S.6
  • 22
    • 19644364586 scopus 로고    scopus 로고
    • The benefit/risk profile of TNF-blocking agents: findings of a consensus panel
    • doi:10.1016/j.semarthrit.2004.11.006
    • Hochberg MC, Lebwohl MG, Plevy SE, Hobbs KF, Yocum DE. The benefit/risk profile of TNF-blocking agents: findings of a consensus panel. Semin Arthritis Rheum (2005) 34(6):819-36. doi:10.1016/j.semarthrit.2004.11.006.
    • (2005) Semin Arthritis Rheum , vol.34 , Issue.6 , pp. 819-836
    • Hochberg, M.C.1    Lebwohl, M.G.2    Plevy, S.E.3    Hobbs, K.F.4    Yocum, D.E.5
  • 23
    • 84857828099 scopus 로고    scopus 로고
    • Kinase inhibitors in the treatment of immune-mediated disease
    • doi:10.3410/M4-5
    • Kontzias A, Laurence A, Gadina M, O'Shea JJ. Kinase inhibitors in the treatment of immune-mediated disease. F1000 Med Rep (2012) 4:5. doi:10.3410/M4-5.
    • (2012) F1000 Med Rep , vol.4 , pp. 5
    • Kontzias, A.1    Laurence, A.2    Gadina, M.3    O'Shea, J.J.4
  • 24
    • 84878345601 scopus 로고    scopus 로고
    • The kinase inhibitor tofacitinib in patients with rheumatoid arthritis: latest findings and clinical potential
    • doi:10.1177/1759720X12470753
    • Cutolo M. The kinase inhibitor tofacitinib in patients with rheumatoid arthritis: latest findings and clinical potential. Ther Adv Musculoskelet Dis (2013) 5(1):3-11. doi:10.1177/1759720X12470753.
    • (2013) Ther Adv Musculoskelet Dis , vol.5 , Issue.1 , pp. 3-11
    • Cutolo, M.1
  • 25
    • 46849108130 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
    • doi:10.1136/ard.2007.074278
    • Schett G, Zwerina J, Firestein G. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis (2008) 67(7):909-16. doi:10.1136/ard.2007.074278.
    • (2008) Ann Rheum Dis , vol.67 , Issue.7 , pp. 909-916
    • Schett, G.1    Zwerina, J.2    Firestein, G.3
  • 26
    • 0019512029 scopus 로고
    • Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates
    • doi:10.1084/jem.154.3.688
    • Wooley PH, Luthra HS, Stuart JM, David CS. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med (1981) 154(3):688-700. doi:10.1084/jem.154.3.688.
    • (1981) J Exp Med , vol.154 , Issue.3 , pp. 688-700
    • Wooley, P.H.1    Luthra, H.S.2    Stuart, J.M.3    David, C.S.4
  • 27
    • 34848840994 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    • doi:10.1002/art.22848
    • Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, Radstake TR, Matera G, Popa C, et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum (2007) 56(9):2957-67. doi:10.1002/art.22848.
    • (2007) Arthritis Rheum , vol.56 , Issue.9 , pp. 2957-2967
    • Abdollahi-Roodsaz, S.1    Joosten, L.A.2    Roelofs, M.F.3    Radstake, T.R.4    Matera, G.5    Popa, C.6
  • 28
    • 77950535933 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan
    • doi:10.1002/art.27335
    • Rosenzweig HL, Jann MJ, Vance EE, Planck SR, Rosenbaum JT, Davey MP. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum (2010) 62(4):1051-9. doi:10.1002/art.27335.
    • (2010) Arthritis Rheum , vol.62 , Issue.4 , pp. 1051-1059
    • Rosenzweig, H.L.1    Jann, M.J.2    Vance, E.E.3    Planck, S.R.4    Rosenbaum, J.T.5    Davey, M.P.6
  • 29
    • 77952483341 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats
    • doi:10.1186/ar3034
    • Meng L, Zhu W, Jiang C, He X, Hou W, Zheng F, et al. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther (2010) 12(3):R103. doi:10.1186/ar3034.
    • (2010) Arthritis Res Ther , vol.12 , Issue.3
    • Meng, L.1    Zhu, W.2    Jiang, C.3    He, X.4    Hou, W.5    Zheng, F.6
  • 30
    • 84865355650 scopus 로고    scopus 로고
    • Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats
    • doi:10.1111/j.1365-3083.2012.02724.x
    • Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, et al. Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scand J Immunol (2012) 76(3):263-70. doi:10.1111/j.1365-3083.2012.02724.x.
    • (2012) Scand J Immunol , vol.76 , Issue.3 , pp. 263-270
    • Zhu, W.1    Meng, L.2    Jiang, C.3    Xu, J.4    Wang, B.5    Han, Y.6
  • 31
    • 79959562364 scopus 로고    scopus 로고
    • Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts
    • doi:10.1186/ar3384
    • Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, et al. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther (2011) 13(3):R103. doi:10.1186/ar3384.
    • (2011) Arthritis Res Ther , vol.13 , Issue.3
    • Zhu, W.1    Meng, L.2    Jiang, C.3    He, X.4    Hou, W.5    Xu, P.6
  • 32
    • 33846922783 scopus 로고    scopus 로고
    • Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs
    • Yarilina A, DiCarlo E, Ivashkiv LB. Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs. J Immunol (2007) 178(4):2204-11.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2204-2211
    • Yarilina, A.1    DiCarlo, E.2    Ivashkiv, L.B.3
  • 33
    • 62449295455 scopus 로고    scopus 로고
    • Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
    • doi:10.1073/pnas.0813037106
    • Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, et al. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A (2009) 106(8):2764-9. doi:10.1073/pnas.0813037106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.8 , pp. 2764-2769
    • Hayashi, T.1    Gray, C.S.2    Chan, M.3    Tawatao, R.I.4    Ronacher, L.5    McGargill, M.A.6
  • 34
    • 84861990802 scopus 로고    scopus 로고
    • Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance
    • doi:10.1186/ar3875
    • Alzabin S, Kong P, Medghalchi M, Palfreeman A, Williams R, Sacre S. Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. Arthritis Res Ther (2012) 14(3):R142. doi:10.1186/ar3875.
    • (2012) Arthritis Res Ther , vol.14 , Issue.3
    • Alzabin, S.1    Kong, P.2    Medghalchi, M.3    Palfreeman, A.4    Williams, R.5    Sacre, S.6
  • 35
    • 84863726250 scopus 로고    scopus 로고
    • Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene
    • doi:10.1038/gt.2011.173
    • Chen SY, Shiau AL, Li YT, Lin YS, Lee CH, Wu CL, et al. Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene. Gene Ther (2012) 19(7):752-60. doi:10.1038/gt.2011.173.
    • (2012) Gene Ther , vol.19 , Issue.7 , pp. 752-760
    • Chen, S.Y.1    Shiau, A.L.2    Li, Y.T.3    Lin, Y.S.4    Lee, C.H.5    Wu, C.L.6
  • 36
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • doi:10.1126/science.1093620
    • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 303(5663):1526-9. doi:10.1126/science.1093620.
    • (2004) Science , vol.303 , Issue.5663 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 38
    • 2442707797 scopus 로고    scopus 로고
    • Nucleosomes are exposed at the cell surface in apoptosis
    • Radic M, Marion T, Monestier M. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol (2004) 172(11):6692-700.
    • (2004) J Immunol , vol.172 , Issue.11 , pp. 6692-6700
    • Radic, M.1    Marion, T.2    Monestier, M.3
  • 39
    • 84856373688 scopus 로고    scopus 로고
    • A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells
    • doi:10.1073/pnas.1109173109
    • Miles K, Heaney J, Sibinska Z, Salter D, Savill J, Gray D, et al. A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proc Natl Acad Sci U S A (2012) 109(3):887-92. doi:10.1073/pnas.1109173109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.3 , pp. 887-892
    • Miles, K.1    Heaney, J.2    Sibinska, Z.3    Salter, D.4    Savill, J.5    Gray, D.6
  • 40
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • doi:10.1086/422827
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 75(2):330-7. doi:10.1086/422827.
    • (2004) Am J Hum Genet , vol.75 , Issue.2 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5    Alexander, H.C.6
  • 41
    • 84895540525 scopus 로고    scopus 로고
    • Rheumatoid arthritis-associated PTPN22 modulates toll-like receptor-mediated, type 1 interferon-dependent innate immunoregulation [abstract]
    • doi:10.1002/art.40183
    • Wang Y, Stanford S, Zhou W, Auger Jennifer L, Cheng G, Campbell A, et al. Rheumatoid arthritis-associated PTPN22 modulates toll-like receptor-mediated, type 1 interferon-dependent innate immunoregulation [abstract]. Arthritis Rheum (2012) 64(Suppl 10):2452. doi:10.1002/art.40183.
    • (2012) Arthritis Rheum , vol.64 , Issue.SUPPL. 10 , pp. 2452
    • Wang, Y.1    Stanford, S.2    Zhou, W.3    Auger Jennifer, L.4    Cheng, G.5    Campbell, A.6
  • 42
    • 66149114790 scopus 로고    scopus 로고
    • Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis
    • doi:10.3899/jrheum.081054
    • Han SW, Lee WK, Kwon KT, Lee BK, Nam EJ, Kim GW. Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis. J Rheumatol (2009) 36(4):693-7. doi:10.3899/jrheum.081054.
    • (2009) J Rheumatol , vol.36 , Issue.4 , pp. 693-697
    • Han, S.W.1    Lee, W.K.2    Kwon, K.T.3    Lee, B.K.4    Nam, E.J.5    Kim, G.W.6
  • 43
    • 17644372231 scopus 로고    scopus 로고
    • Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis
    • doi:10.1186/ar1165
    • van Holten J, Reedquist K, Sattonet-Roche P, Smeets TJ, Plater-Zyberk C, Vervoordeldonk MJ, et al. Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2004) 6(3):R239-49. doi:10.1186/ar1165.
    • (2004) Arthritis Res Ther , vol.6 , Issue.3
    • van Holten, J.1    Reedquist, K.2    Sattonet-Roche, P.3    Smeets, T.J.4    Plater-Zyberk, C.5    Vervoordeldonk, M.J.6
  • 44
    • 58849134282 scopus 로고    scopus 로고
    • Interferon beta for rheumatoid arthritis: new clothes for an old kid on the block
    • doi:10.1136/ard.2008.097899
    • Vervoordeldonk MJ, Aalbers CJ, Tak PP. Interferon beta for rheumatoid arthritis: new clothes for an old kid on the block. Ann Rheum Dis (2009) 68(2):157-8. doi:10.1136/ard.2008.097899.
    • (2009) Ann Rheum Dis , vol.68 , Issue.2 , pp. 157-158
    • Vervoordeldonk, M.J.1    Aalbers, C.J.2    Tak, P.P.3
  • 45
    • 84863222361 scopus 로고    scopus 로고
    • A TLR 9 antagonist diminishes arthritis severity in a rat model of rheumatoid arthritis
    • doi:10.1136/ard.2010.148973.8
    • Herman S, Fischer A, Pfatschbacher J, Hoffmann M, Steiner G. A TLR 9 antagonist diminishes arthritis severity in a rat model of rheumatoid arthritis. Ann Rheum Dis (2011) 70(Suppl 2):A39. doi:10.1136/ard.2010.148973.8.
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 2
    • Herman, S.1    Fischer, A.2    Pfatschbacher, J.3    Hoffmann, M.4    Steiner, G.5
  • 46
    • 78650606709 scopus 로고    scopus 로고
    • Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
    • doi:10.1073/pnas.1010603107
    • Kawane K, Tanaka H, Kitahara Y, Shimaoka S, Nagata S. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A (2010) 107(45):19432-7. doi:10.1073/pnas.1010603107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.45 , pp. 19432-19437
    • Kawane, K.1    Tanaka, H.2    Kitahara, Y.3    Shimaoka, S.4    Nagata, S.5
  • 47
    • 0036841956 scopus 로고    scopus 로고
    • Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes
    • doi:10.1002/path.1224
    • Paulsen F, Pufe T, Conradi L, Varoga D, Tsokos M, Papendieck J, et al. Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. J Pathol (2002) 198(3):369-77. doi:10.1002/path.1224.
    • (2002) J Pathol , vol.198 , Issue.3 , pp. 369-377
    • Paulsen, F.1    Pufe, T.2    Conradi, L.3    Varoga, D.4    Tsokos, M.5    Papendieck, J.6
  • 48
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • doi:10.1016/j.immuni.2006.07.013
    • Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 25(3):417-28. doi:10.1016/j.immuni.2006.07.013.
    • (2006) Immunity , vol.25 , Issue.3 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 49
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • doi:10.1084/jem.20050914
    • Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 202(8):1131-9. doi:10.1084/jem.20050914.
    • (2005) J Exp Med , vol.202 , Issue.8 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6
  • 50
    • 77649124410 scopus 로고    scopus 로고
    • Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors
    • doi:10.1002/art.27304
    • Sacre S, Medghalchi M, Gregory B, Brennan F, Williams R. Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum (2010) 62(3):683-93. doi:10.1002/art.27304.
    • (2010) Arthritis Rheum , vol.62 , Issue.3 , pp. 683-693
    • Sacre, S.1    Medghalchi, M.2    Gregory, B.3    Brennan, F.4    Williams, R.5
  • 51
    • 79954847184 scopus 로고    scopus 로고
    • Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis
    • doi:10.1016/j.jaut.2011.02.007
    • Hoffmann MH, Skriner K, Herman S, Baumann C, Steiner CW, Ospelt C, et al. Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis. J Autoimmun (2011) 36(3-4):288-300. doi:10.1016/j.jaut.2011.02.007.
    • (2011) J Autoimmun , vol.36 , Issue.3-4 , pp. 288-300
    • Hoffmann, M.H.1    Skriner, K.2    Herman, S.3    Baumann, C.4    Steiner, C.W.5    Ospelt, C.6
  • 52
    • 77952888454 scopus 로고    scopus 로고
    • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    • doi:10.1038/ng.582
    • Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 42(6):508-14. doi:10.1038/ng.582.
    • (2010) Nat Genet , vol.42 , Issue.6 , pp. 508-514
    • Stahl, E.A.1    Raychaudhuri, S.2    Remmers, E.F.3    Xie, G.4    Eyre, S.5    Thomson, B.P.6
  • 53
    • 78650748817 scopus 로고    scopus 로고
    • Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome
    • doi:10.1371/journal.pone.0014326
    • Coenen MJ, Enevold C, Barrera P, Schijvenaars MM, Toonen EJ, Scheffer H, et al. Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome. PLoS One (2010) 5(12):e14326. doi:10.1371/journal.pone.0014326.
    • (2010) PLoS One , vol.5 , Issue.12
    • Coenen, M.J.1    Enevold, C.2    Barrera, P.3    Schijvenaars, M.M.4    Toonen, E.J.5    Scheffer, H.6
  • 54
    • 60849125397 scopus 로고    scopus 로고
    • No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis
    • doi:10.1186/ar2589
    • Jaen O, Petit-Teixeira E, Kirsten H, Ahnert P, Semerano L, Pierlot C, et al. No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. Arthritis Res Ther (2009) 11(1):R5. doi:10.1186/ar2589.
    • (2009) Arthritis Res Ther , vol.11 , Issue.1
    • Jaen, O.1    Petit-Teixeira, E.2    Kirsten, H.3    Ahnert, P.4    Semerano, L.5    Pierlot, C.6
  • 55
    • 80054889306 scopus 로고    scopus 로고
    • The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients
    • doi:10.1007/s00296-010-1472-8
    • Etem EO, Elyas H, Ozgocmen S, Yildirim A, Godekmerdan A. The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients. Rheumatol Int (2011) 31(10):1369-74. doi:10.1007/s00296-010-1472-8.
    • (2011) Rheumatol Int , vol.31 , Issue.10 , pp. 1369-1374
    • Etem, E.O.1    Elyas, H.2    Ozgocmen, S.3    Yildirim, A.4    Godekmerdan, A.5
  • 56
    • 77951831491 scopus 로고    scopus 로고
    • Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis
    • doi:10.3899/jrheum.090775
    • Enevold C, Radstake TR, Coenen MJ, Fransen J, Toonen EJ, Bendtzen K, et al. Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis. J Rheumatol (2010) 37(5):905-10. doi:10.3899/jrheum.090775.
    • (2010) J Rheumatol , vol.37 , Issue.5 , pp. 905-910
    • Enevold, C.1    Radstake, T.R.2    Coenen, M.J.3    Fransen, J.4    Toonen, E.J.5    Bendtzen, K.6
  • 57
    • 33947545388 scopus 로고    scopus 로고
    • The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    • doi:10.2353/ajpath.2007.060657
    • Sacre SM, Andreakos E, Kiriakidis S, Amjadi P, Lundberg A, Giddins G, et al. The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J Pathol (2007) 170(2):518-25. doi:10.2353/ajpath.2007.060657.
    • (2007) Am J Pathol , vol.170 , Issue.2 , pp. 518-525
    • Sacre, S.M.1    Andreakos, E.2    Kiriakidis, S.3    Amjadi, P.4    Lundberg, A.5    Giddins, G.6
  • 58
    • 71849117626 scopus 로고    scopus 로고
    • Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    • Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol (2008) 181(11):8002-9.
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 8002-8009
    • Sacre, S.M.1    Lo, A.2    Gregory, B.3    Simmonds, R.E.4    Williams, L.5    Feldmann, M.6
  • 59
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    • doi:10.1002/art.21273
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum (2005) 52(9):2656-65. doi:10.1002/art.21273.
    • (2005) Arthritis Rheum , vol.52 , Issue.9 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 60
    • 57349192121 scopus 로고    scopus 로고
    • Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis
    • doi:10.1002/art.24140
    • Ospelt C, Brentano F, Rengel Y, Stanczyk J, Kolling C, Tak PP, et al. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum (2008) 58(12):3684-92. doi:10.1002/art.24140.
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 3684-3692
    • Ospelt, C.1    Brentano, F.2    Rengel, Y.3    Stanczyk, J.4    Kolling, C.5    Tak, P.P.6
  • 61
    • 79955551778 scopus 로고    scopus 로고
    • Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis
    • doi:10.3899/jrheum.100732
    • Tamaki Y, Takakubo Y, Hirayama T, Konttinen YT, Goodman SB, Yamakawa M, et al. Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis. J Rheumatol (2011) 38(5):810-20. doi:10.3899/jrheum.100732.
    • (2011) J Rheumatol , vol.38 , Issue.5 , pp. 810-820
    • Tamaki, Y.1    Takakubo, Y.2    Hirayama, T.3    Konttinen, Y.T.4    Goodman, S.B.5    Yamakawa, M.6
  • 62
    • 23644449245 scopus 로고    scopus 로고
    • The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • doi:10.1002/art.21278
    • Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, van Lieshout AW, Sprong T, van den Hoogen FH, et al. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum (2005) 52(8):2313-22. doi:10.1002/art.21278.
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3    van Lieshout, A.W.4    Sprong, T.5    van den Hoogen, F.H.6
  • 63
    • 84897980594 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1alpha provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis
    • doi:10.1136/annrheumdis-2012-202444.
    • Hu F, Mu R, Zhu J, Shi L, Li Y, Liu X, et al. Hypoxia and hypoxia-inducible factor-1alpha provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis (2013). doi:10.1136/annrheumdis-2012-202444.
    • (2013) Ann Rheum Dis
    • Hu, F.1    Mu, R.2    Zhu, J.3    Shi, L.4    Li, Y.5    Liu, X.6
  • 64
    • 78650967552 scopus 로고    scopus 로고
    • Engagement of toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts
    • doi:10.3904/kjim.2010.25.4.429
    • Moon SJ, Park MK, Oh HJ, Lee SY, Kwok SK, Cho ML, et al. Engagement of toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts. Korean J Intern Med (2010) 25(4):429-35. doi:10.3904/kjim.2010.25.4.429.
    • (2010) Korean J Intern Med , vol.25 , Issue.4 , pp. 429-435
    • Moon, S.J.1    Park, M.K.2    Oh, H.J.3    Lee, S.Y.4    Kwok, S.K.5    Cho, M.L.6
  • 65
    • 65649133618 scopus 로고    scopus 로고
    • TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis
    • doi:10.1016/j.imlet.2009.02.006
    • Kim KW, Cho ML, Oh HJ, Kim HR, Kang CM, Heo YM, et al. TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis. Immunol Lett (2009) 124(1):9-17. doi:10.1016/j.imlet.2009.02.006.
    • (2009) Immunol Lett , vol.124 , Issue.1 , pp. 9-17
    • Kim, K.W.1    Cho, M.L.2    Oh, H.J.3    Kim, H.R.4    Kang, C.M.5    Heo, Y.M.6
  • 66
    • 33846420161 scopus 로고    scopus 로고
    • Blood serum DNA in patients with rheumatoid arthritis is considerably enriched with fragments of ribosomal repeats containing immunostimulatory CpG-motifs
    • doi:10.1007/s10517-006-0354-2
    • Veiko NN, Shubaeva NO, Ivanova SM, Speranskii AI, Lyapunova NA, Spitkovskii DM. Blood serum DNA in patients with rheumatoid arthritis is considerably enriched with fragments of ribosomal repeats containing immunostimulatory CpG-motifs. Bull Exp Biol Med (2006) 142(3):313-6. doi:10.1007/s10517-006-0354-2.
    • (2006) Bull Exp Biol Med , vol.142 , Issue.3 , pp. 313-316
    • Veiko, N.N.1    Shubaeva, N.O.2    Ivanova, S.M.3    Speranskii, A.I.4    Lyapunova, N.A.5    Spitkovskii, D.M.6
  • 67
    • 80054831143 scopus 로고    scopus 로고
    • LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs
    • doi:10.1371/journal.pone.0026632
    • Lai Y, Adhikarakunnathu S, Bhardwaj K, Ranjith-Kumar CT, Wen Y, Jordan JL, et al. LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. PLoS One (2011) 6(10):e26632. doi:10.1371/journal.pone.0026632.
    • (2011) PLoS One , vol.6 , Issue.10
    • Lai, Y.1    Adhikarakunnathu, S.2    Bhardwaj, K.3    Ranjith-Kumar, C.T.4    Wen, Y.5    Jordan, J.L.6
  • 68
    • 69549135324 scopus 로고    scopus 로고
    • Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
    • doi:10.1084/jem.20090480
    • Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med (2009) 206(9):1983-94. doi:10.1084/jem.20090480.
    • (2009) J Exp Med , vol.206 , Issue.9 , pp. 1983-1994
    • Ganguly, D.1    Chamilos, G.2    Lande, R.3    Gregorio, J.4    Meller, S.5    Facchinetti, V.6
  • 69
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • doi:10.1038/nature06116
    • Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 449(7162):564-9. doi:10.1038/nature06116.
    • (2007) Nature , vol.449 , Issue.7162 , pp. 564-569
    • Lande, R.1    Gregorio, J.2    Facchinetti, V.3    Chatterjee, B.4    Wang, Y.H.5    Homey, B.6
  • 70
    • 0023132716 scopus 로고
    • Antimalarials in rheumatology: efficacy and safety
    • doi:10.1016/0049-0172(87)90023-0
    • Maksymowych W, Russell AS. Antimalarials in rheumatology: efficacy and safety. Semin Arthritis Rheum (1987) 16(3):206-21. doi:10.1016/0049-0172(87)90023-0.
    • (1987) Semin Arthritis Rheum , vol.16 , Issue.3 , pp. 206-221
    • Maksymowych, W.1    Russell, A.S.2
  • 71
    • 0029890174 scopus 로고    scopus 로고
    • The role of anti-malarials in rheumatoid arthritis-the American experience
    • doi:10.1177/096120339600500110
    • Khraishi MM, Singh G. The role of anti-malarials in rheumatoid arthritis-the American experience. Lupus (1996) 5(Suppl 1):S41-4. doi:10.1177/096120339600500110.
    • (1996) Lupus , vol.5 , Issue.SUPPL.1
    • Khraishi, M.M.1    Singh, G.2
  • 72
    • 33645281948 scopus 로고    scopus 로고
    • CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion
    • doi:10.1083/jcb.200508058
    • Sanjuan MA, Rao N, Lai KT, Gu Y, Sun S, Fuchs A, et al. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol (2006) 172(7):1057-68. doi:10.1083/jcb.200508058.
    • (2006) J Cell Biol , vol.172 , Issue.7 , pp. 1057-1068
    • Sanjuan, M.A.1    Rao, N.2    Lai, K.T.3    Gu, Y.4    Sun, S.5    Fuchs, A.6
  • 73
    • 79955046267 scopus 로고    scopus 로고
    • Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines
    • doi:10.4049/jimmunol.1000702
    • Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol (2011) 186(8):4794-804. doi:10.4049/jimmunol.1000702.
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4794-4804
    • Kuznik, A.1    Bencina, M.2    Svajger, U.3    Jeras, M.4    Rozman, B.5    Jerala, R.6
  • 74
    • 84895536833 scopus 로고    scopus 로고
    • VentiRx. [cited 2013 Oct 18]
    • VentiRx. TLR8 Antagonist. (2013) [cited 2013 Oct 18]. Available from: http://www.ventirx.com/product/tlr8-antagonist.htm.
    • (2013) TLR8 Antagonist
  • 76
    • 77954478293 scopus 로고    scopus 로고
    • TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin
    • doi:10.1007/s12272-010-0618-2
    • Park SJ, Lee AN, Youn HS. TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin. Arch Pharm Res (2010) 33(6):939-45. doi:10.1007/s12272-010-0618-2.
    • (2010) Arch Pharm Res , vol.33 , Issue.6 , pp. 939-945
    • Park, S.J.1    Lee, A.N.2    Youn, H.S.3
  • 78
    • 77953723966 scopus 로고    scopus 로고
    • TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    • doi:10.1038/nature09102
    • Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature (2010) 465(7300):937-41. doi:10.1038/nature09102.
    • (2010) Nature , vol.465 , Issue.7300 , pp. 937-941
    • Guiducci, C.1    Gong, M.2    Xu, Z.3    Gill, M.4    Chaussabel, D.5    Meeker, T.6
  • 79
    • 84895545616 scopus 로고    scopus 로고
    • Dynavax. [cited 2013 Oct 18]
    • Dynavax. Pipeline: Autoimmunity/Inflammation. (2013) [cited 2013 Oct 18]. Available from: http://www.dynavax.com/autoimmunity.html.
    • (2013) Pipeline: Autoimmunity/Inflammation
  • 80
    • 84895560115 scopus 로고    scopus 로고
    • Idera. [cited 2013 Oct 18]
    • Idera. Clinical Programs: Overview. (2013) [cited 2013 Oct 18]. Available from: http://www.iderapharma.com/clinical-trials.
    • (2013) Clinical Programs: Overview
  • 81
    • 84876067752 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
    • doi:10.1093/nar/gkt078
    • Kandimalla ER, Bhagat L, Wang D, Yu D, Sullivan T, La Monica N, et al. Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. Nucleic Acids Res (2013) 41(6):3947-61. doi:10.1093/nar/gkt078.
    • (2013) Nucleic Acids Res , vol.41 , Issue.6 , pp. 3947-3961
    • Kandimalla, E.R.1    Bhagat, L.2    Wang, D.3    Yu, D.4    Sullivan, T.5    La Monica, N.6


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