Blood serum DNA in patients with rheumatoid arthritis is considerably enriched with fragments of ribosomal repeats containing immunostimulatory CpG-motifs

Bulletin of Experimental Biology and Medicine

Volumn 142, Issue 3, 2006, Pages 313-316

  Veiko, N N ^a   Shubaeva, N O ^b   Ivanova, S M ^b   Speranskii, A I ^b   Lyapunova, N A ^a   Spitkovskii, D M ^a  

^a RESEARCH CENTRE FOR MEDICAL GENETICS   (Russian Federation)

^b V A NASONOVA RESEARCH INSTITUTE OF RHEUMATOLOGY   (Russian Federation)

Author keywords

DNA CpG motifs; rDNA; Rheumatoid arthritis; TLR9

Indexed keywords

BACTERIAL DNA; RIBOSOME DNA; TOLL LIKE RECEPTOR 9;

ARTICLE; BLOOD SAMPLING; CELL NUCLEUS; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA STRAND BREAKAGE; DOT HYBRIDIZATION; HUMAN; LEUKOCYTE; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CPG ISLANDS; DNA; DNA, RIBOSOMAL; DNA-BINDING PROTEINS; HUMANS; TOLL-LIKE RECEPTOR 9;

BACTERIA (MICROORGANISMS);

EID: 33846420161     PISSN: 00074888     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10517-006-0354-2     Document Type: Article

References (15)

1. N. N. Veiko, N. A. Egolina, G. G. Radzivil, et al., Mol. Biol., 37, No. 3, 409-419 (2003).
2. N. N. Veiko and D. M. Spitkovskii, Radiats. Biol. Radioekol., 40, 396-404 (2000).
3. S. Bauer, C. Kirschning, H. Hacker, et al., Proc. Natl. Acad. Sci. USA 98, 9237-9242 (2001).
4. A. Bird, Nature, 321, 209-213 (1986).
5. R. Branda, A. Moore, R. Hong, et al., Clin. Immunol. Immunopathol., 79, 115-121 (1996).
6. G. Brock and A. Bird, Hum. Mol. Genet., 6, 451-456 (1997).
7. M. Galeazzi, G. Morozzi, M. Piccini, et al., Autoimmun. Rev., 2, 50-55 (2003).
8. H. Hemmi, O. Takeuchi, T. Kawai, et al., Nature, 408, 740-745 (2000).
9. D. Klinman, Expert Opin. Biol. Ther., 4, 937-946 (2004).
10. F. Krapf, M. Herrmann, W. Leitmann, and J. Kalden J., Rheumatol. Int., 9, 115-121 (1989).
11. A. Krieg, A. Yi, S. Matson, et al., Nature, 374, 546-549 (1995).
12. K. Stacey, G. Young, and F. Clark, J. Immunol., 170, 3614-3620 (2003).
13. G. Viglianti, C. Lau, T. Hanley, et al., Immunity, 19, 837-847 (2003).
14. H. Wagner, Immunity, 14, 499-502 (2001).
15. H. Wagner, Curr. Opin. Microbiol., 5, 62-69 (2002).