Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 387-396

  Zhu, Hai Liang ^a   Duan, Yong Tao ^a   Wang, Zhong Chang ^a   Sang, Ya Li ^a   Tao, Xiang Xiang ^a   Teraiya, Shashikant B ^a   Wang, Peng Fei ^a   Wen, Qing ^a   Zhou, Xiao Jing ^a   Ding, Liang ^a   Yang, Yong Hua ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

5 Nitroimidazole; Antibacterial activities; Cytotoxicity; FabH inhibitors

Indexed keywords

2 (5 NITRO 2 STYRYL 1H IMIDAZOL 1 YL)ETHANOL; 2 [2 (2 CHLORO 6 FLUROYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2 CHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2 NITROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2,4 DICHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (2,4 DIMETHYLAMINOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (3 BROMOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (3 CHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (3 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (3 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (3 NITROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (4 BROMOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (4 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (4 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (4 METHYLSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 (4 NITROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 [2 (NAPHTHALEN 1 YL)VINYL] 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 [2 (NAPHTHALEN 2 YL)VINYL] 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 [4 (BENZYLOXY)STYRYL] 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 2 [2 [4 (DIMETHOXYMETHYL)STYRYL] 5 NITRO 1H IMIDAZOL 1 YL]ETHANOL; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 5 NITROIMIDAZOLE DERIVATIVE; ACYL CARRIER PROTEIN; ANTIBIOTIC AGENT; FATTY ACID SYNTHASE INHIBITOR; KANAMYCIN; PENICILLAMINE; UNCLASSIFIED DRUG; 4-NITROIMIDAZOLE; ACYLTRANSFERASE; ANTIINFECTIVE AGENT; ESCHERICHIA COLI PROTEIN; FABH PROTEIN, E COLI; FATTY ACID SYNTHASE; NITROIMIDAZOLE DERIVATIVE; STYRENE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACILLUS THURINGIENSIS; BACTERIAL STRAIN; BACTERIAL SURVIVAL; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME PURIFICATION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; ANTAGONISTS AND INHIBITORS; CHEMISTRY; MICROBIAL SENSITIVITY TEST; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHASE, TYPE II; MICROBIAL SENSITIVITY TESTS; NITROIMIDAZOLES; STYRENE;

EID: 84895509168     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.004     Document Type: Article

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