1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5368-5371

  Zhan, Peng ^a   Liu, Xinyong ^a   Cao, Yuan ^a   Wang, Yan ^a   Pannecouque, Christophe ^b   De Clercq, Erik ^b  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,2,3 Thiadiazole; HIV; NNRTIs; SAR; Synthesis; Thiadiazole thioacetanilides

Indexed keywords

1,2,3 THIADIAZOLE THIOACETANILIDE DERIVATIVE; 2 [4 (2,4 DICHLOROPHENYL) 1,2,3 THIADIAZOL 5 YLTHIO] N (2 NITROPHENYL)ACETAMIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; BIOLOGICAL ASSAY; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, CHEMICAL; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 53349162138     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.055     Document Type: Article

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