Synthesis of C(7) modified chrysin derivatives designing to inhibit β-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6264-6269

  Li, Huan Qiu ^a   Shi, Lei ^a   Li, Qing Shan ^a   Liu, Peng Gang ^a   Luo, Yin ^a   Zhao, Jing ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibiotics; Chrysin derivatives; FabH; Structure activity relationship

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE III; 5 HYDROXY 2 PHENYL 7 [2 (PIPERAZIN 1 YL)ETHOXY] 4H CHROMEN 4 ONE; ANTIBIOTIC AGENT; CHRYSIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PROTEIN FUNCTION; PSEUDOMONAS FLUORESCENS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; ESCHERICHIA COLI; FLAVONOIDS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 68649084460     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.046     Document Type: Article

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