Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N′-phenyl-thiourea

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5708-5715

  Zhang, Hong Jia ^a   Qin, Xuan ^a   Liu, Kai ^a   Zhu, Di Di ^a   Wang, Xiao Ming ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibacterial activity; FabH inhibitors; Schiff base; Structure activity relationship

Indexed keywords

1 (2 (2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (3,5 DIBROMO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (4 BROMOBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (4 CHLOROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (4 METHOXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (5 BROMO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (2 (5 CHLORO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (2 FLUOROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (2 NITROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (2,4 DICHLOROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (3 BROMOBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (3 METHOXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (3,5 DIBROMO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (4 BROMOBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (4 CHLOROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (4 FLUOROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (4 METHYLBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (4 NITROBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (5 BROMO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; 1 (4 (5 CHLORO 2 HYDROXYBENZYLIDENEAMINO)PHENYL) 3 PHENYLTHIOUREA; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; KANAMYCIN; N (2 BENZALDEHYDE AMINO)PHENYL N' PHENYL THIOUREA; N (4 BENZALDEHYDE AMINO)PHENYL N' PHENYL THIOUREA; PENICILLIN G; SCHIFF BASE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; SCHIFF BASES; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 80052578837     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.077     Document Type: Article

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