Clock genes: Their role in colorectal cancer

World Journal of Gastroenterology

Volumn 20, Issue 8, 2014, Pages 1986-1992

  Karantanos, Theodoros ^a   Theodoropoulos, George ^a   Pektasides, Dimitrios ^a   Gazouli, Maria ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Clock genes; Colorectal cancer; Development; Prognosis

Indexed keywords

BETA CATENIN; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CHECKPOINT KINASE 2; CRY PROTEIN; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN E; DEC1 PROTEIN; DEC2 PROTEIN; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; MYC PROTEIN; NPAS2 PROTEIN; NUCLEAR RECEPTOR NR1D1; PEPTIDES AND PROTEINS; PER1 PROTEIN; PER2 PROTEIN; PER3 PROTEIN; PROTEIN BMAL1; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PROTEIN TIMELESS; RETINOID RELATED ORPHAN RECEPTOR ALPHA; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG; WEE1 PROTEIN; WNT PROTEIN; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CIRCADIAN RHYTHM SIGNALING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; NUCLEAR PROTEIN; PER2 PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; WEE1 PROTEIN, HUMAN;

AGGRESSIVENESS; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CIRCADIAN RHYTHM; CLOCK GENE; COLORECTAL CANCER; DNA DAMAGE; DNA REPAIR; EPIGENETICS; GENE; GENE EXPRESSION; HUMAN; LYMPH NODE METASTASIS; METABOLISM; MICROARRAY ANALYSIS; MICROSATELLITE INSTABILITY; MUTATION; NEGATIVE FEEDBACK; NONHUMAN; PHOSPHORYLATION; POSITIVE FEEDBACK; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL; ANIMAL; CELL CYCLE; CELL DIFFERENTIATION; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; PROGNOSIS;

ANIMALS; BETA CATENIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CIRCADIAN RHYTHM; CLOCK PROTEINS; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE PROGRESSION; DNA DAMAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NUCLEAR PROTEINS; PERIOD CIRCADIAN PROTEINS; PROGNOSIS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTORS;

EID: 84894566886     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i8.1986     Document Type: Article

References (59)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30 [PMID: 23335087 DOI: 10.3322/caac.21166]
2. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, Starling N. Colorectal cancer. Lancet 2010; 375: 1030-1047 [PMID: 20304247 DOI: 10.1016/ S0140-6736(10)60353-4]
3. Davies JM, Goldberg RM. Treatment of metastatic colorectal cancer. Semin Oncol 2011; 38: 552-560 [PMID: 21810514 DOI: 10.1053/j.seminoncol.2011.05.009]
4. Kloog I, Haim A, Stevens RG, Portnov BA. Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men. Chronobiol Int 2009; 26: 108-125 [PMID: 19142761 DOI: 10.1080/07420520802694020]
5. Viswanathan AN, Schernhammer ES. Circulating melatonin and the risk of breast and endometrial cancer in women. Cancer Lett 2009; 281: 1-7 [PMID: 19070424 DOI: 10.1016/ j.canlet.2008.11.002]
6. Anderson LE, Morris JE, Sasser LB, Stevens RG. Effect of constant light on DMBA mammary tumorigenesis in rats. Cancer Lett 2000; 148: 121-126 [PMID: 10695987 DOI: 10.1016/ S0304-3835(99)00320-1]
7. Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. Deletion of the PER3 gene on chromosome 1p36 in recurrent ERpositive breast cancer. J Clin Oncol 2010; 28: 3770-3778 [PMID: 20625127 DOI: 10.1200/JCO.2009.27.0215]
8. Hsu CM, Lin SF, Lu CT, Lin PM, Yang MY. Altered expression of circadian clock genes in head and neck squamous cell carcinoma. Tumour Biol 2012; 33: 149-155 [PMID: 22081375 DOI: 10.1007/s13277-011-0258-2]
9. Borgs L, Beukelaers P, Vandenbosch R, Belachew S, Nguyen L, Malgrange B. Cell "circadian" cycle: new role for mammalian core clock genes. Cell Cycle 2009; 8: 832-837 [PMID: 19221497]
10. Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TD, Weitz CJ, Takahashi JS, Kay SA. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 1998; 280: 1599-1603 [PMID: 9616122]
11. Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 2006; 22: 375-382 [PMID: 16678109]
12. Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, Niittymäki I, Lehtonen HJ, Kivioja T, Launonen V, Saharinen J, Nousiainen K, Hautaniemi S, Nuorva K, Mecklin JP, Järvinen H, Orntoft T, Arango D, Lehtonen R, Karhu A, Taipale J, Aaltonen LA. Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res 2010; 8: 952-960 [PMID: 20551151 DOI: 10.1158/1541-7786]
13. Zeng ZL, Wu MW, Sun J, Sun YL, Cai YC, Huang YJ, Xian LJ. Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem 2010; 148: 319-326 [PMID: 20576619 DOI: 10.1093/jb/mvq069]
14. Gréchez-Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F. The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem 2008; 283: 4535-4542 [PMID: 18086663]
15. Lin F, Chen Y, Li X, Zhao Q, Tan Z. Over-expression of circadian clock gene Bmal1 affects proliferation and the canonical Wnt pathway in NIH-3T3 cells. Cell Biochem Funct 2013; 31: 166-172 [PMID: 22961668 DOI: 10.1002/cbf.2871]
16. Soták M, Polidarová L, Ergang P, Sumová A, Pácha J. An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors. Int J Cancer 2013; 132: 1032-1041 [PMID: 22865596 DOI: 10.1002/ijc.27760]
17. Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, Menaker M, Takahashi JS. PERIOD2: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 2004; 101: 5339-5346 [PMID: 14963227]
18. Nishide SY, Honma S, Nakajima Y, Ikeda M, Baba K, Ohmiya Y, Honma K. New reporter system for Per1 and Bmal1 expressions revealed self-sustained circadian rhythms in peripheral tissues. Genes Cells 2006; 11: 1173-1182 [PMID: 16999737]
19. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. Role of the CLOCK protein in the mammalian circadian mechanism. Science 1998; 280: 1564-1569 [PMID: 9616112]
20. Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol 2008; 28: 4080-4092 [PMID: 18411297 DOI: 10.1128/MCB.02168-07]
21. Landskron J, Chen KF, Wolf E, Stanewsky R. A role for the PERIOD: PERIOD homodimer in the Drosophila circadian clock. PLoS Biol 2009; 7: e3 [PMID: 19402744 DOI: 10.1371/ journal.pbio.1000003]
22. Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, Schibler U. The orphan nuclear receptor REVERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 2002; 110: 251-260 [PMID: 12150932]
23. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol 2004; 24: 584-594 [PMID: 14701732]
24. Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 2007; 450: 1086-1090 [PMID: 18075593]
25. Arango D, Mariadason JM, Wilson AJ, Yang W, Corner GA, Nicholas C, Aranes MJ, Augenlicht LH. c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. Br J Cancer 2003; 89: 1757-1765 [PMID: 14583781]
26. Pelengaris S, Khan M. The many faces of c-MYC. Arch Biochem Biophys 2003; 416: 129-136 [PMID: 12893289]
27. Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell 2005; 122: 803-815 [PMID: 16143109]
28. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 2002; 111: 41-50 [PMID: 12372299]
29. Sun CM, Huang SF, Zeng JM, Liu DB, Xiao Q, Tian WJ, Zhu XD, Huang ZG, Feng WL. Per2 inhibits k562 leukemia cell growth in vitro and in vivo through cell cycle arrest and apoptosis induction. Pathol Oncol Res 2010; 16: 403-411 [PMID: 19957060 DOI: 10.1007/s12253-009-9227-0]
30. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003; 302: 255-259 [PMID: 12934012]
31. van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999; 398: 627-630 [PMID: 10217146]
32. Backert S, Gelos M, Kobalz U, Hanski ML, Böhm C, Mann B, Lövin N, Gratchev A, Mansmann U, Moyer MP, Riecken EO, Hanski C. Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array. Int J Cancer 1999; 82: 868-874 [PMID: 10446455]
33. Schneikert J, Behrens J. The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut 2007; 56: 417-425 [PMID: 16840506]
34. Jansson EA, Are A, Greicius G, Kuo IC, Kelly D, Arulampalam V, Pettersson S. The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. Proc Natl Acad Sci USA 2005; 102: 1460-1465 [PMID: 15665104]
35. Wood PA, Yang X, Taber A, Oh EY, Ansell C, Ayers SE, Al-Assaad Z, Carnevale K, Berger FG, Peña MM, Hrushesky WJ. Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res 2008; 6: 1786-1793 [PMID: 19010825 DOI: 10.1158/1541-7786.MCR-08-0196]
36. Yang X, Wood PA, Ansell CM, Ohmori M, Oh EY, Xiong Y, Berger FG, Peña MM, Hrushesky WJ. Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. J Biochem 2009; 145: 289-297 [PMID: 19106159 DOI: 10.1093/jb/mvn167]
37. Sahar S, Zocchi L, Kinoshita C, Borrelli E, Sassone-Corsi P. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One 2010; 5: e8561 [PMID: 20049328 DOI: 10.1371/journal. pone.0008561]
38. Zhang R, Qin W, Xu GL, Zeng FF, Li CX. A metaanalysis of the prevalence of somatic mutations in the hMLH1 and hMSH2 genes in colorectal cancer. Colorectal Dis 2012; 14: e80-e89 [PMID: 21988782 DOI: 10.1111/ j.1463-1318.2011.02858.x]
39. Grabsch H, Dattani M, Barker L, Maughan N, Maude K, Hansen O, Gabbert HE, Quirke P, Mueller W. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Clin Cancer Res 2006; 12: 1494-1500 [PMID: 16533773]
40. Beggs AD, Domingo E, McGregor M, Presz M, Johnstone E, Midgley R, Kerr D, Oukrif D, Novelli M, Abulafi M, Hodgson SV, Fadhil W, Ilyas M, Tomlinson IP. Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. Oncotarget 2012; 3: 1348-1355 [PMID: 23154512]
41. Takabayashi H, Wakai T, Ajioka Y, Korita PV, Yamaguchi N. Alteration of the DNA damage response in colorectal tumor progression. Hum Pathol 2013; 44: 1038-1046 [PMID: 23332927 DOI: 10.1016/j.humpath.2012.09.006]
42. Yang X, Wood PA, Hrushesky WJ. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J Biol Chem 2010; 285: 3030-3034 [PMID: 19996108 DOI: 10.1074/jbc.M109.050237]
43. Kondratov RV, Antoch MP. Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol 2007; 17: 311-317 [PMID: 17644383]
44. Unsal-Kaçmaz K, Mullen TE, Kaufmann WK, Sancar A. Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol 2005; 25: 3109-3116 [PMID: 15798197]
45. Hoffman AE, Zheng T, Ba Y, Zhu Y. The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. Mol Cancer Res 2008; 6: 1461-1468 [PMID: 18819933]
46. Mazzoccoli G, Panza A, Valvano MR, Palumbo O, Carella M, Pazienza V, Biscaglia G, Tavano F, Di Sebastiano P, Andriulli A, Piepoli A. Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int 2011; 28: 841-851 [PMID: 22080729 DOI: 10.3109/07420528.2011.615182]
47. Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, Numata K, Shiozawa M, Rino Y, Tanaka K, Masuda M, Imada T. Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep 2011; 25: 1439-1446 [PMID: 21380491 DOI: 10.3892/ or.2011.1207]
48. Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Lymberi M, Pektasides D. Expression of clock genes in patients with colorectal cancer. Int J Biol Markers 2013; 28: 280-285 [PMID: 23712462 DOI: 10.5301/ jbm.5000033]
49. Barrat-Petit MA, Naulin-Ifi C, Mahler P, Milano G. Dihydropyrimidine deshydrogenase (DPD): rhythm and consequences. Pathol Biol (Paris) 2005; 53: 261-264 [PMID: 15939134]
50. Raida M, Kliche KO, Schwabe W, Häusler P, Clement JH, Behnke D, Höffken K. Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls. J Cancer Res Clin Oncol 2002; 128: 96-102 [PMID: 11862480]
51. Krugluger W, Brandstaetter A, Kállay E, Schueller J, Krexner E, Kriwanek S, Bonner E, Cross HS. Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res 2007; 67: 7917-7922 [PMID: 17699798]
52. Zeman M, Vician M, Monosíková J, Reis R, Herichová I. Deregulated expression of the per2 gene in human colorectal carcinoma. Mol Med Rep 2008; 1: 599-603 [PMID: 21479457]
53. Wang Y, Hua L, Lu C, Chen Z. Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma. World J Surg Oncol 2011; 9: 166 [PMID: 22166120 DOI: 10.1186/1477-7819-9-166]
54. Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R, Huang W. Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One 2013; 8: e61679 [PMID: 23626715 DOI: 10.1371/journal.pone.0061679]
55. Hughes M, Deharo L, Pulivarthy SR, Gu J, Hayes K, Panda S, Hogenesch JB. High-resolution time course analysis of gene expression from pituitary. Cold Spring Harb Symp Quant Biol 2007; 72: 381-386 [PMID: 18419295 DOI: 10.1101/ sqb.2007.72.011]
56. Zhou F, He X, Liu H, Zhu Y, Jin T, Chen C, Qu F, Li Y, Bao G, Chen Z, Xing J. Functional polymorphisms of circadian positive feedback regulation genes and clinical outcome of Chinese patients with resected colorectal cancer. Cancer 2012; 118: 937-946 [PMID: 21773969 DOI: 10.1002/cncr.26348]
57. Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Stravopodis DJ, Bramis K, Lymperi M, Pektasidis D. Association of the clock genes polymorphisms with colorectal cancer susceptibility. J Surg Oncol 2013; Epub ahead of print [PMID: 24037774 DOI: 10.1002/jso.23434]
58. Tan X, Zhang P, Zhou L, Yin B, Pan H, Peng X. Clock-controlled mir-142-3p can target its activator, Bmal1. BMC Mol Biol 2012; 13: 27 [PMID: 22958478 DOI: 10.1186/1471-2199-13-27]
59. Wang V, Wu W. MicroRNA-based therapeutics for cancer. BioDrugs 2009; 23: 15-23 [PMID: 19344188 DOI: 10.2165/0006 3030-200923010-00002]