Loss of expression of ATM is associated with worse prognosis in colorectal cancer and loss of ku70 expression is associated with CIN

Oncotarget

Volumn 3, Issue 11, 2012, Pages 1348-1355

  Beggs, Andrew ^a,f   Domingo, Enric ^a   McGregor, Megan ^b   Presz, Mikael ^b   Johnstone, Elaine ^b   Midgley, Rachel ^b   Kerr, David ^c   Oukrif, Dahmane ^d   Novelli, Marco ^d   Abulafi, Muti ^f   Hodgson, Shirley ^g   Fadhil, Wakkas ^e   Ilyas, Mohammad ^e   Tomlinson, Ian P M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f MAYDAY UNIVERSITY HOSPITAL   (United Kingdom)

^g ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

ATM; Colorectal cancer; Double strand break repair; Prognosis; Y H2AX

Indexed keywords

ATM PROTEIN; B RAF KINASE; GAMMA HISTONE H2AX; HISTONE H2AX; K RAS PROTEIN; KU ANTIGEN; PLACEBO; ROFECOXIB; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CELL NUCLEUS ANTIGEN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; BRAF GENE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; CHROMOSOMAL INSTABILITY; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; FEMALE; GENE; GENE MUTATION; GENOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; ONCOGENE K RAS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); TUMOR LOCALIZATION; BIOSYNTHESIS; COLORECTAL TUMOR; GENETIC POLYMORPHISM; GENETICS; KAPLAN MEIER METHOD; METABOLISM; PROGNOSIS;

ANTIGENS, NUCLEAR; CELL CYCLE PROTEINS; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; DOWN-REGULATION; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; POLYMORPHISM, GENETIC; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 84872765095     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.694     Document Type: Article

References (18)

1. Agarwal S, Tafel AA and Kanaar R. DNA double-strand break repair and chromosome translocations. DNA Repair (Amst). 2006; 5(9-10):1075-1081.
2. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S and Pommier Y. GammaH2AX and cancer. Nat Rev Cancer. 2008; 8(12):957-967.
3. Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gasser PJ, Park MS, Sung P and Lee EY. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Ch m. 1999; 274(18):12748-12752.
4. Tanaka T, Huang X, Jorgensen E, Gietl D, Traganos F, Darzynkiewicz Z and Albino AP. ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke. BMC Cell Biol. 2007; 8:26.
5. Stucki M and Jackson SP. gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst). 2006; 5(5):534-543.
6. Lu C, Shi Y, Wang Z, Song Z, Zhu M, Cai Q and Chen T. Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway. FEBS Lett. 2008; 582(18):2703-2708.
7. Grabsch H, Dattani M, Barker L, Maughan N, Maude K, Hansen O, Gabbert HE, Quirke P and Mueller W. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Clin Cancer Res. 2006; 12(5):1494-1500.
8. Rigas B, Borgo S, Elhosseiny A, Balatsos V, Manika Z, Shinya H, Kurihara N, Go M and Lipkin M. Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis. Cancer Res. 2001; 61(23):8381-8384.
9. Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Tsuno N, Kazama S, Kitayama J, Suzuki N and Nagawa H. The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer. 2002; 95(6):1199-1205.
10. Kerr DJ, Dunn JA, Langman MJ, Smith JL, Midgley RS, Stanley A, Stokes JC, Julier P, Iveson C, Duvvuri R and McConkey CC. Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer. N Engl J Med. 2007; 357(4):360-369.
11. Leedham SJ, Graham TA, Oukrif D, McDonald SA, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR, Jankowski JA and Wright NA. Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia. Gastroenterology. 2009; 136(2):542-550 e546.
12. Buhmeida A, Algars A, Ristamaki R, Collan Y, Syrjanen K and Pyrhonen S. DNA image cytometry is a useful adjunct tool in the prediction of disease outcome in patients with stage II and stage III colorectal cancer. Oncology. 2006; 70(6):427-437.
13. Teoh NC, Dan YY, Swisshelm K, Lehman S, Wright JH, Haque J, Gu Y and Fausto N. Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology. 2008; 47(6):2078-2088.
14. Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I and Kerr D. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer. 2009; 9(7):489-499.
15. Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Suzuki N and Nagawa H. Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer. Hepato-gastroenterology. 2005; 52(64):995-998.
16. Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, et al. Genomic instability in mice lacking histone H2AX. Science. 2002; 296(5569):922-927.
17. van Gent DC, Hoeijmakers JH and Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nature reviews Genetics. 2001; 2(3):196-206.
18. Iliakis G. The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. BioEssays: news and reviews in molecular, cellular and developmental biology. 1991; 13(12):641-648.