β-catenin induces β-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice

Journal of Biochemistry

Volumn 145, Issue 3, 2009, Pages 289-297

  Yang, Xiaoming ^a   Wood, Patricia A ^a,b   Ansell, Christine M ^a   Ohmori, Masami ^a   Oh, Eun Yeong ^a   Xiong, Yin ^a,b   Berger, Franklin G ^c   Peña, Maria Marjorette O ^c   Hrushesky, William J M ^a,b  

^a WJB Dorn VA Medical Center   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

catenin; TrCP; Circadian; Colon cancer; Per2

Indexed keywords

BETA CATENIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; PER1 PROTEIN; PER2 PROTEIN; PROTEIN BMAL1; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; PER2 PROTEIN, HUMAN; PER2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK;

ARTICLE; CELL STRAIN HCT116; CIRCADIAN RHYTHM; COLON CANCER; COLON POLYPOSIS; CONTROLLED STUDY; DBP GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTESTINE MUCOSA; INTESTINE TUMOR; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN STABILITY; SMALL INTESTINE MUCOSA; TRANSGENIC MOUSE; WEE1 GENE; ANIMAL; C57BL MOUSE; DOWN REGULATION; GENETICS; METABOLISM; MOTOR ACTIVITY; PROTEIN PROCESSING;

MUS;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BETA CATENIN; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL CYCLE PROTEINS; CIRCADIAN RHYTHM; DOWN-REGULATION; HCT116 CELLS; HUMANS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NUCLEAR PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 66549118111     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn167     Document Type: Article

References (43)

1. You, S., Wood, P.A., Xiong, Y., Kobayashi, M., Du-Quiton, J., and Hrushesky, W.J. (2005) Daily Coordination Of Cancer Growth And Circadian Clock Gene Expression. Breast Cancer Res. Treat. 91, 47-60
2. Wood, P.A., Du-Quiton, J., You, S., and Hrushesky, W.J. (2006) Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Mol. Cancer Ther. 5, 2023-2033
3. Klevecz, R.R., Shymko, R.M., Blumenfeld, D., and Braly, P.S. (1987) Circadian gating of S phase in human ovarian cancer. Cancer Res. 47, 6267-6271 (Pubitemid 18011075)
4. Hrushesky, W.J. (1985) Circadian timing of cancer chemotherapy. Science 228, 73-75
5. Wood, P.A., Hrushesky, W.J., and Klevecz, R. (1998) Distinct circadian time structures characterize myeloid and erythroid progenitor and multipotential cell clonogenicity as well as marrow precursor proliferation dynamics. Exp Hematol. 26, 523-533
6. Hrushesky, W.J.M., Lannin, D., and Haus, E. (1998) Evidence for an ontogenetic basis for circadian coordination of cancer cell proliferation. J. Nat. Cancer Inst. 90, 1480-1484
7. Reppert, S.M. and Weaver, D.R. (2002) Coordination of circadian timing in mammals. Nature 418, 935-941
8. Lee, C., Etchegaray, J.P., Cagampang, F.R., Loudon, A.S., and Reppert, S.M. (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 107, 855-867 (Pubitemid 34084977)
9. Yamamoto, Y., Yagita, K., and Okamura, H. (2005) Role of cyclic mPer2 expression in the mammalian cellular clock. Mol. Cell Biol. 25, 1912-1921
10. Gallego, M. and Virshup, D.M. (2007) Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell Biol. 8, 139-148
11. Shirogane, T., Jin, J., Ang, X.L., and Harper, J.W. (2005) SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280, 26863-26872
12. Eide, E.J., Woolf, M.F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E.L., Giovanni, A., and Virshup, D.M. (2005) Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol. Cell Biol. 25, 2795-2807
13. Siepka, S.M., Yoo, S.H., Park, J., Song, W., Kumar, V., Hu, Y., Lee, C., and Takahashi, J.S. (2007) Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129, 1011-1023 (Pubitemid 46802705)
14. Miller, B.H., McDearmon, E.L., Panda, S., Hayes, K.R., Zhang, J., Andrews, J.L., Antoch, M.P., Walker, J.R., Esser, K.A., Hogenesch, J.B., and Takahashi, J.S. (2007) Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc. Natl Acad. Sci. USA 104, 3342-3347
15. Koyanagi, S., Kuramoto, Y., Nakagawa, H., Aramaki, H., Ohdo, S., Soeda, S., and Shimono, H. (2003) A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. Cancer Res. 63, 7277-7283 (Pubitemid 37413468)
16. Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., and Okamura, H. (2003) Control mechanism of the circadian clock for timing of cell division in vivo. Science 302, 255-259 (Pubitemid 37248750)
17. Griniatsos, J., Michail, O.P., Theocharis, S., Arvelakis, A., Papaconstantinou, I., Felekouras, E., Pikoulis, E., Karavokyros, I., Bakoyiannis, C., Marinos, G., Bramis, J., and Michail, P.O. (2006) Circadian variation in expression of G1 phase cyclins D1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa. World J. Gastroenterol. 12, 2109-2114
18. Fu, L. and Lee, C.C. (2003) The circadian clock: pacemaker and tumour suppressor. Nat. Rev. Cancer 3, 350-361
19. Fu, L., Pelicano, H., Liu, J., Huang, P., and Lee, C. (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 41-50
20. Chen, S.T., Choo, K.B., Hou, M.F., Yeh, K.T., Kuo, S.J., and Chang, J.G. (2005) Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 26, 1241-1246
21. Sjoblom, T., Jones, S., Wood, L.D., Parsons, D.W., Lin, J., Barber, T.D., Mandelker, D., Leary, R.J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S.D., Willis, J., Dawson, D., Willson, J.K., Gazdar, A.F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B.H., Bachman, K.E., Papadopoulos, N., Vogelstein, B., Kinzler, K.W., and Velculescu, V.E. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274 (Pubitemid 44571966)
22. Zeman, M., Vician, M., Monosikova, J., Reis, R., and Herichova, I. (2008) Deregulated expression of the Per2 gene in human colorectal carcinoma. Molecular Med. Rep. 1, 599-603
23. Yang, X., Wood, P.A., Oh, E.Y., Du-Quiton, J., Ansell, C.M., and Hrushesky, W.J. (2008) Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res. Treat.
24. Wood, P.A. and Hrushesky, W.J. (1996) Circadian rhythms and cancer chemotherapy. Crit. Rev. Eukaryot. Gene Expr. 6, 299-343
25. Min/+ Tumorigenesis. Mol. Can. Res. 6, 1786-1793
26. Karim, R., Tse, G., Putti, T., Scolyer, R., and Lee, S. (2004) The significance of the Wnt pathway in the pathology of human cancers. Pathology 36, 120-128 (Pubitemid 38507872)
27. Kolligs, F.T., Bommer, G., and Goke, B. (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66, 131-144 (Pubitemid 36091845)
28. Schneikert, J. and Behrens, J. (2007) The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut. 56, 417-425 (Pubitemid 46579774)
29. Frescas, D. and Pagano, M. (2008) Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat. Rev. Cancer. 8, 438-449
30. Ougolkov, A., Zhang, B., Yamashita, K., Bilim, V., Mai, M., Fuchs, S.Y., and Minamoto, T. (2004) Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. J. Natl. Cancer Inst. 96, 1161-1170
31. Lincoln, D.W., II, Hrushesky, W.J., and Wood, P.A. (2000) Circadian organization of thymidylate synthase activity in normal tissues: a possible basis for 5-fluorouracil chronotherapeutic advantage. Int. J. Cancer. 88, 479-485
32. He, T.C., Sparks, A.B., Rago, C., Hermeking, H., Zawel, L., da Costa, L.T., Morin, P.J., Vogelstein, B., and Kinzler, K.W. (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512
33. Noubissi, F.K., Elcheva, I., Bhatia, N., Shakoori, A., Ougolkov, A., Liu, J., Minamoto, T., Ross, J., Fuchs, S.Y., and Spiegelman, V.S. (2006) CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature 441, 898-901 (Pubitemid 43910426)
34. Spiegelman, V.S., Slaga, T.J., Pagano, M., Minamoto, T., Ronai, Z., and Fuchs, S.Y. (2000) Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell 5, 877-882
35. Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., and Takumi, T. (2004) Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol. Biol. 5, 18
36. Ripperger, J.A. and Schibler, U. (2006) Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat. Genet. 38, 369-374
37. Ripperger, J.A., Shearman, L.P., Reppert, S.M., and Schibler, U. (2000) CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev. 14, 679-689
38. Ghaleb, A.M., McConnell, B.B., Nandan, M.O., Katz, J.P., Kaestner, K.H., and Yang, V.W. (2007) Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67, 7147-7154
39. Mahmoud, N.N., Boolbol, S.K., Bilinski, R.T., Martucci, C., Chadburn, A., and Bertagnolli, M.M. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res. 57, 5045-5050 (Pubitemid 27498118)
40. Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M., and Weaver, D.R. (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30, 525-536 (Pubitemid 32530594)
41. Albrecht, U., Zheng, B., Larkin, D., Sun, Z.S., and Lee, C.C. (2001) MPer1 and mper2 are essential for normal resetting of the circadian clock. J. Biol. Rhythms 16, 100-104 (Pubitemid 32391905)
42. Biasco, G., Cenacchi, G., Nobili, E., Pantaleo, M.A., Calabrese, C., Di Febo, G., Morselli Labate, A., Miglioli, M., and Brandi, G. (2004) Cell proliferation and ultrastructural changes of the duodenal mucosa of patients affected by familial adenomatous polyposis. Hum. Pathol. 35, 622-626
43. Brandi, G., Calabrese, C., Pantaleo, M.A., Morselli Labate, A., Di Febo, G., Hakim, R., De Vivo, A., Di Marco, M.C., and Biasco, G. (2004) Circadian variations of rectal cell proliferation in patients affected by advanced colorectal cancer. Cancer Lett. 208, 193-196 (Pubitemid 38624161)