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Volumn 67, Issue 16, 2007, Pages 7917-7922

Regulation of genes of the circadian clock in human colon cancer: Reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; PER1 PROTEIN; PER2 PROTEIN; TRANSCRIPTION FACTOR CLOCK;

EID: 34548049941     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0133     Document Type: Article
Times cited : (89)

References (50)
  • 1
    • 13844294265 scopus 로고    scopus 로고
    • Pharmacogenetic influences on treatment response and toxicity in colorectal cancer
    • Tan BR, McLeod HL. Pharmacogenetic influences on treatment response and toxicity in colorectal cancer. Semin Oncol 2005;32:13-9.
    • (2005) Semin Oncol , vol.32 , pp. 13-19
    • Tan, B.R.1    McLeod, H.L.2
  • 2
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • Van Kuilenburg AB. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 2004;40:939-50.
    • (2004) Eur J Cancer , vol.40 , pp. 939-950
    • Van Kuilenburg, A.B.1
  • 3
    • 16544376696 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration
    • Ezzeldin H, Diasio R. Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration. Clin Colorectal Cancer 2004;4:181-9.
    • (2004) Clin Colorectal Cancer , vol.4 , pp. 181-189
    • Ezzeldin, H.1    Diasio, R.2
  • 4
    • 12544258457 scopus 로고    scopus 로고
    • Lethal toxicity after 5-fluorouracil chemotherapy and its possible relationship to dihydropyrimidine dehydrogenase deficiency: A case report and review of the literature
    • Diaz R, Segura A, Aparizio J, Calderero V, Guerrero A, Pellin L. Lethal toxicity after 5-fluorouracil chemotherapy and its possible relationship to dihydropyrimidine dehydrogenase deficiency: a case report and review of the literature. J Chemother 2004;16:599-603.
    • (2004) J Chemother , vol.16 , pp. 599-603
    • Diaz, R.1    Segura, A.2    Aparizio, J.3    Calderero, V.4    Guerrero, A.5    Pellin, L.6
  • 5
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FN, Kouni MH, Cha S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 1985;45:5405-12.
    • (1985) Cancer Res , vol.45 , pp. 5405-5412
    • Naguib, F.N.1    Kouni, M.H.2    Cha, S.3
  • 6
    • 0034813250 scopus 로고    scopus 로고
    • Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels
    • Tanaka-Nozaki M, Onda M, Tanaka N, Kato S. Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels. Clin Cancer Res 2001;7:2783-7.
    • (2001) Clin Cancer Res , vol.7 , pp. 2783-2787
    • Tanaka-Nozaki, M.1    Onda, M.2    Tanaka, N.3    Kato, S.4
  • 7
    • 0032862086 scopus 로고    scopus 로고
    • Regulation of dihydropyrimidine dehydrogenase in colorectal cancer
    • Johnston SJ, Ridge SA, Cassidy J, McLeod HL. Regulation of dihydropyrimidine dehydrogenase in colorectal cancer. Clin Cancer Res 1999;5:2566-70.
    • (1999) Clin Cancer Res , vol.5 , pp. 2566-2570
    • Johnston, S.J.1    Ridge, S.A.2    Cassidy, J.3    McLeod, H.L.4
  • 8
    • 33746461039 scopus 로고    scopus 로고
    • Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer
    • Okumura K, Shiomi H, Mekata E, et al. Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer. Oncol Rep 2006;15:875-82.
    • (2006) Oncol Rep , vol.15 , pp. 875-882
    • Okumura, K.1    Shiomi, H.2    Mekata, E.3
  • 9
    • 33750702299 scopus 로고    scopus 로고
    • Molecular factors of 5-fluorouracil metabolism in colorectal cancer: Analysis of primary tumor and lymph node metastasis
    • Vallbohmer D, Kuramochi H, Shimizu D, et al. Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis. Int J Oncol 2006;28:527-33.
    • (2006) Int J Oncol , vol.28 , pp. 527-533
    • Vallbohmer, D.1    Kuramochi, H.2    Shimizu, D.3
  • 10
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 2000;6:1322-7.
    • (2000) Clin Cancer Res , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3
  • 11
    • 33750719963 scopus 로고    scopus 로고
    • The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer
    • Hotta T, Takifuji K, Taniguchi K, et al. The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer. Oncol Rep 2006;16:177-82.
    • (2006) Oncol Rep , vol.16 , pp. 177-182
    • Hotta, T.1    Takifuji, K.2    Taniguchi, K.3
  • 12
    • 0141455146 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: Predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Kornmann M, Schwabe W, Sander S, et al. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res 2003;9:4116-24.
    • (2003) Clin Cancer Res , vol.9 , pp. 4116-4124
    • Kornmann, M.1    Schwabe, W.2    Sander, S.3
  • 13
    • 0037375992 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: Comparison between enzyme activity and gene expression
    • Porsin B, Formento JL, Filipski E, et al. Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression. Eur J Cancer 2003;39:822-8.
    • (2003) Eur J Cancer , vol.39 , pp. 822-828
    • Porsin, B.1    Formento, J.L.2    Filipski, E.3
  • 14
    • 0036159940 scopus 로고    scopus 로고
    • Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls
    • Raida M, Kliche KO, Schwabe W, et al. Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls. J Cancer Res Clin Oncol 2001;128:96-102.
    • (2001) J Cancer Res Clin Oncol , vol.128 , pp. 96-102
    • Raida, M.1    Kliche, K.O.2    Schwabe, W.3
  • 15
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris BE, Song R, Soong SJ, Diasio RB. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 1990;50:197-201.
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.J.3    Diasio, R.B.4
  • 17
    • 0035370886 scopus 로고    scopus 로고
    • Circadian regulation of gene expression in animals
    • Ripperger JA, Schibler U. Circadian regulation of gene expression in animals. Curr Opin Cell Biol 2001;13:357-62.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 357-362
    • Ripperger, J.A.1    Schibler, U.2
  • 19
    • 0033637383 scopus 로고    scopus 로고
    • Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachismatic nucleus
    • Damiola F, Minh N, Prenitner N, Kornmann B, Fleury-Olela F, Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachismatic nucleus. Genes Dev 2000;14:2950-61.
    • (2000) Genes Dev , vol.14 , pp. 2950-2961
    • Damiola, F.1    Minh, N.2    Prenitner, N.3    Kornmann, B.4    Fleury-Olela, F.5    Schibler, U.6
  • 20
    • 0037184977 scopus 로고    scopus 로고
    • A web of circadian pacemakers
    • Schibler U, Sassone-Corsi P. A web of circadian pacemakers. Cell 2002;111:919-22.
    • (2002) Cell , vol.111 , pp. 919-922
    • Schibler, U.1    Sassone-Corsi, P.2
  • 22
    • 0035004799 scopus 로고    scopus 로고
    • Circadian expression of clock genes in human oral mucosa and skin
    • Bjarnason GA, Jordan RCK, Wood PA, et al. Circadian expression of clock genes in human oral mucosa and skin. Am J Pathol 2001;158:1793-801.
    • (2001) Am J Pathol , vol.158 , pp. 1793-1801
    • Bjarnason, G.A.1    Jordan, R.C.K.2    Wood, P.A.3
  • 23
    • 30344453348 scopus 로고    scopus 로고
    • Human intestinal circadian clock: Expression of clock genes in colonocytes lining the crypt
    • Pardini L, Kaeffer B, Trubuil A, Bourreille A, Galmiche JP. Human intestinal circadian clock: expression of clock genes in colonocytes lining the crypt. Chronobiol Int 2005;22:951-61.
    • (2005) Chronobiol Int , vol.22 , pp. 951-961
    • Pardini, L.1    Kaeffer, B.2    Trubuil, A.3    Bourreille, A.4    Galmiche, J.P.5
  • 24
    • 34548038840 scopus 로고    scopus 로고
    • ABI prism 7700 sequence detection system: Relative quantitation of gene expression. Bulletin 2, PE Applied Biosystems 2001;1-36.
    • ABI prism 7700 sequence detection system: Relative quantitation of gene expression. Bulletin 2, PE Applied Biosystems 2001;1-36.
  • 25
    • 0036092643 scopus 로고    scopus 로고
    • Functional genomics of sleep and circadian rhythm. Invited review: Regulation of mammalian circadian clock genes
    • Albrecht U. Functional genomics of sleep and circadian rhythm. Invited review: regulation of mammalian circadian clock genes. J Appl Physiol 2002;92:1348-55.
    • (2002) J Appl Physiol , vol.92 , pp. 1348-1355
    • Albrecht, U.1
  • 27
    • 0037987902 scopus 로고    scopus 로고
    • Circadian and seasonal rhythms. Integration of mammalian circadian clock signals: From molecule to behavior
    • Okamura H. Circadian and seasonal rhythms. Integration of mammalian circadian clock signals: from molecule to behavior. J Endocrinol 2003;177:3-6.
    • (2003) J Endocrinol , vol.177 , pp. 3-6
    • Okamura, H.1
  • 28
    • 0018742875 scopus 로고
    • Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus
    • Stephan FK, Swann JM, Sisk CL. Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus. Behav Neural Biol 1979;25:346-63.
    • (1979) Behav Neural Biol , vol.25 , pp. 346-363
    • Stephan, F.K.1    Swann, J.M.2    Sisk, C.L.3
  • 29
    • 0000193024 scopus 로고    scopus 로고
    • Food entrainable oscillators in mammals
    • Takahashi J, Turek FW, Moore RY, editors, New York: Plenum Publishers;
    • Stephan FK. Food entrainable oscillators in mammals. In: Takahashi J, Turek FW, Moore RY, editors. Handbook of behavioral neurobiology 12: Circadian clocks. New York: Plenum Publishers; 2001. pp. 223-41.
    • (2001) Handbook of behavioral neurobiology 12: Circadian clocks , pp. 223-241
    • Stephan, F.K.1
  • 31
    • 34548028795 scopus 로고    scopus 로고
    • Garufi GA, Bjarnason S, Giacchetti P, et al. Independent prognostic value of the rest/activity circadian rhythm on overall survival (OS) in patients (pts) with metastatic colorectal cancer (MCC) receiving first line chemotherapy with 5-fluorouracil, leucovorin and oxaliplatin: a companion study to EORTC 05963. J Clin Oncol 2005 American Society of Clinical Oncology Annual Meeting Proceedings. 23, No. 16S, Part I of II ( June 1 Supplement), 2005:3553.
    • Garufi GA, Bjarnason S, Giacchetti P, et al. Independent prognostic value of the rest/activity circadian rhythm on overall survival (OS) in patients (pts) with metastatic colorectal cancer (MCC) receiving first line chemotherapy with 5-fluorouracil, leucovorin and oxaliplatin: a companion study to EORTC 05963. J Clin Oncol 2005 American Society of Clinical Oncology Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II ( June 1 Supplement), 2005:3553.
  • 32
    • 18744429390 scopus 로고    scopus 로고
    • Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status
    • Mormont MC, Waterhouse J, Bleuzen P, et al. Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status. Clin Cancer Res 2000;6:3038-45.
    • (2000) Clin Cancer Res , vol.6 , pp. 3038-3045
    • Mormont, M.C.1    Waterhouse, J.2    Bleuzen, P.3
  • 33
  • 34
    • 0036567347 scopus 로고    scopus 로고
    • Host circadian clock as a control point in tumor progression
    • Filipski E, King VM, Li X, et al. Host circadian clock as a control point in tumor progression. J Natl Cancer Inst 2002;94:690-7.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 690-697
    • Filipski, E.1    King, V.M.2    Li, X.3
  • 35
    • 33645522609 scopus 로고    scopus 로고
    • Disruption of circadian coordination and malignant growth
    • Filipski E, Li XM, Levi F. Disruption of circadian coordination and malignant growth.. Cancer Causes Control 2006;17:509-14.
    • (2006) Cancer Causes Control , vol.17 , pp. 509-514
    • Filipski, E.1    Li, X.M.2    Levi, F.3
  • 36
    • 33749259773 scopus 로고    scopus 로고
    • Promoter methylation in circadian genes of endometrial cancers detected by methylation-specific PCR
    • Shih MC, Yeh KT, Tang KP, Chen JC, Chang JG. Promoter methylation in circadian genes of endometrial cancers detected by methylation-specific PCR. Mol Carcinog 2006;45:732-40.
    • (2006) Mol Carcinog , vol.45 , pp. 732-740
    • Shih, M.C.1    Yeh, K.T.2    Tang, K.P.3    Chen, J.C.4    Chang, J.G.5
  • 37
    • 0023876379 scopus 로고
    • Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients
    • Petit E, Milano G, Levi F, Thyss A, Bailleul F, Schneider M. Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients. Cancer Res 1988;48:1676-9.
    • (1988) Cancer Res , vol.48 , pp. 1676-1679
    • Petit, E.1    Milano, G.2    Levi, F.3    Thyss, A.4    Bailleul, F.5    Schneider, M.6
  • 38
    • 0031010583 scopus 로고    scopus 로고
    • Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells
    • Grem JL, Yee LK, Venzon DJ, Takimoto CH, Allegra CJ. Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells. Cancer Chemother Pharmacol 1997;40:117-25.
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 117-125
    • Grem, J.L.1    Yee, L.K.2    Venzon, D.J.3    Takimoto, C.H.4    Allegra, C.J.5
  • 39
    • 33747886951 scopus 로고    scopus 로고
    • Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: Evidence for a novel timing system
    • Silberstein GB, Van Horn K, Hrah-Robinson E, Compton J. Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: evidence for a novel timing system. J Endocrinol 2006;190:225-39.
    • (2006) J Endocrinol , vol.190 , pp. 225-239
    • Silberstein, G.B.1    Van Horn, K.2    Hrah-Robinson, E.3    Compton, J.4
  • 41
    • 28444462963 scopus 로고    scopus 로고
    • Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats
    • Nakamura TJ, Moriya T, Inoue S, et al. Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J Neurosci Res 2005;82:622-30.
    • (2005) J Neurosci Res , vol.82 , pp. 622-630
    • Nakamura, T.J.1    Moriya, T.2    Inoue, S.3
  • 42
    • 33644863308 scopus 로고    scopus 로고
    • Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms
    • Numano R, Yamazaki S, Umeda N, et al. Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms. Proc Natl Acad Sci U S A 2006;103:3716-21.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3716-3721
    • Numano, R.1    Yamazaki, S.2    Umeda, N.3
  • 43
    • 18144406584 scopus 로고    scopus 로고
    • Abnormal expression of period 1 (PER1) in endometrial carcinoma
    • Yeh KT, Yang MY, Liu TC, et al. Abnormal expression of period 1 (PER1) in endometrial carcinoma. J Pathol 2005;206:111-20.
    • (2005) J Pathol , vol.206 , pp. 111-120
    • Yeh, K.T.1    Yang, M.Y.2    Liu, T.C.3
  • 45
    • 33747060772 scopus 로고    scopus 로고
    • Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group
    • Giachetti S, Bjarnason G, Garufi C, et al. Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group. J Clin Oncol 2006;24:3562-9.
    • (2006) J Clin Oncol , vol.24 , pp. 3562-3569
    • Giachetti, S.1    Bjarnason, G.2    Garufi, C.3
  • 46
    • 33244468377 scopus 로고    scopus 로고
    • Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors - correlation to tumor histopathology and clinical follow-up
    • Lassmann S, Henning M, Rosenberg R, et al. Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors - correlation to tumor histopathology and clinical follow-up. Int J Colorectal Dis 2006;21:238-47.
    • (2006) Int J Colorectal Dis , vol.21 , pp. 238-247
    • Lassmann, S.1    Henning, M.2    Rosenberg, R.3
  • 47
    • 0037312517 scopus 로고    scopus 로고
    • Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W, Uetake H, Shirota Y, et al. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 2003;9:786-91.
    • (2003) Clin Cancer Res , vol.9 , pp. 786-791
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3
  • 48
    • 33846085042 scopus 로고    scopus 로고
    • Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Ciaparrone M, Quirino M, Schinzari G, et al. Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil. Oncology 2006;70:366-77.
    • (2006) Oncology , vol.70 , pp. 366-377
    • Ciaparrone, M.1    Quirino, M.2    Schinzari, G.3
  • 49
    • 33748376677 scopus 로고    scopus 로고
    • Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index
    • Wood PA, Du-Quiton J, You S, Hrushesky WJ. Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Mol Cancer Ther 2006;5:2023-33.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2023-2033
    • Wood, P.A.1    Du-Quiton, J.2    You, S.3    Hrushesky, W.J.4
  • 50
    • 33646084831 scopus 로고    scopus 로고
    • The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells
    • Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 2006;22:375-82.
    • (2006) Mol Cell , vol.22 , pp. 375-382
    • Gery, S.1    Komatsu, N.2    Baldjyan, L.3    Yu, A.4    Koo, D.5    Koeffler, H.P.6


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