Retrospective analysis of the Draize test for serious eye damage/eye irritation: Importance of understanding the in vivo endpoints under un GHS/EU CLP for the development and evaluation of in vitro test methods

Archives of Toxicology

Volumn 88, Issue 3, 2014, Pages 701-723

  Adriaens, Els ^a   Barroso, João ^b   Eskes, Chantra ^b,j   Hoffmann, Sebastian ^b,k   McNamee, Pauline ^c   Alépée, Nathalie ^d   Bessou Touya, Sandrine ^e   De Smedt, Ann ^f   De Wever, Bart ^g   Pfannenbecker, Uwe ^h   Tailhardat, Magalie ⁱ   Zuang, Valérie ^b  

^a Adriaens Consulting BVBA   (Belgium)

^b JOINT RESEARCH CENTRE   (Italy)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d L ORÉAL RECHERCHE   (France)

^e INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^f JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^g HENKEL KGAA   (Germany)

^h BEIERSDORF AG   (Germany)

ⁱ Département Innovation Matériaux et Technologies   (France)

^j Services and Consultation on Alternative Methods Sagl (SeCAM)   (Switzerland)

^k Seh Consulting + Services   (Germany)

more..

Author keywords

Draize within test variability; Drivers of classification; Eye irritation serious eye damage; UN GHS EU CLP; Validation of in vitro methods

Indexed keywords

IRRITANT AGENT;

ANIMAL; CLASSIFICATION; CONJUNCTIVA; CORNEA; DRUG EFFECTS; DRUG SCREENING; EUROPEAN UNION; EYE; FACTUAL DATABASE; PROBABILITY; PROCEDURES; RABBIT; RETROSPECTIVE STUDY; STANDARDS; TOXICITY TESTING; UNITED NATIONS;

ANIMALS; CONJUNCTIVA; CORNEA; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; EUROPEAN UNION; EYE; IRRITANTS; PROBABILITY; RABBITS; RETROSPECTIVE STUDIES; TOXICITY TESTS; UNITED NATIONS;

EID: 84894564745     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1156-8     Document Type: Article

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