Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals

Toxicology in Vitro

Volumn 20, Issue 1, 2006, Pages 1-17

  Van Goethem, F ^a   Adriaens, E ^b   Alepee N ^c   Straube, F ^d   De Wever, B ^e   Cappadoro, M ^e   Catoire, S ^c   Hansen, E ^a   Wolf, A ^d   Vanparys, P ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c PFIZER INC   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e SkinEthic Laboratories   (France)

Author keywords

Alternative method; Eye irritation; Prevalidation

Indexed keywords

2 ETHYLHEXANOL; 4 METHYL 2 PENTANONE; ACETONE; ALCOHOL; BENZALKONIUM CHLORIDE; CETYLPYRIDINIUM SALT; CYCLOHEXANOL; CYCLOPENTANE DERIVATIVE; GLYCEROL; HEXANOL; IRRITANT AGENT; KETONE; MACROGOL; OCTANOL; PENTANE; PENTANOL; POLYSORBATE 20; PROPANEDIOL DERIVATIVE; SODIUM HYDROXIDE; TOLUENE; TRITON X 100;

ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOTOXICITY; EYE IRRITATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PREDICTION; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STANDARDIZATION; VALIDATION PROCESS;

ACUTE TOXICITY TESTS; CORNEA; EYE; HUMANS; IRRITANTS; ORGANIC CHEMICALS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS;

ORYCTOLAGUS CUNICULUS;

EID: 29144468687     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.05.002     Document Type: Article

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