Principal component analysis of Draize eye, irritation tissue scores from 72 samples of 55 chemicals in the ECETOC data bank

Toxicology in Vitro

Volumn 10, Issue 5, 1996, Pages 609-618

  Lovell, D P ^a  

^a BIBRA INTERNATIONAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; BENZALKONIUM CHLORIDE; CETYLPYRIDINIUM SALT; CHEMICAL AGENT; TRITON X 100;

ANIMAL EXPERIMENT; ARTICLE; EYE IRRITATION; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; RABBIT; TOXICITY TESTING;

EID: 0030268034     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(96)00039-2     Document Type: Article

References (6)

1. Bagley D. M., Botham P. A., Gardner J. R., Holland G., Kreiling R., Lewis R. W., Stringer D. A. and Walker A. P. (1992) Eye irritation: reference chemicals data bank. Toxicology in Vitro 6, 487-491.
2. Chatfield C. and Collins A. J. (1980) An Introduction to Multivariate Analysis. Chapman and Hall, London.
3. Draize J. H., Woodard G. and Calvery H. O. (1944) Methods for the study of irritation and toxicity of substances applied to the skin and mucous membranes. Journal of Pharmacology and Experimental Therapeutics 82, 377-390.
4. ECETOC (1992) Eye Irritation: Reference Chemicals Data Bank. Technical Report No. 48. European Chemical Industry Ecology and Toxicology Centre, Brussels.
5. Koeter H. B. W. M. (1991) Current guidelines and regulations in toxicological research. In Replacement, Reduction and Refinement: Present Possibilities and Future Prospects. Edited by C. F. M. Hendriksen and H. B. W. M. Koeter, pp. 17-34. Elsevier, Amsterdam.
6. OECD (1987) OECD Guidelines for Testing of Chemicals: Test Guideline 405, Acute Eye Irritation/Corrosion, Organisation for Economic Cooperation and Development, adopted 24 February 1987.