NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1

Oncogene

Volumn 33, Issue 8, 2014, Pages 996-1005

  Yu, Y ^a,b   Zhang, D ^a   Huang, H ^a,c   Li, J ^a   Zhang, M ^a,c   Wan, Y ^b   Gao, J ^c   Huang, C ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WUHAN UNIVERSITY   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Akt S6 ribosomal protein; miR 190; p50; p53 translation; PHLPP1

Indexed keywords

ANIMALS; ARSENITES; BASE SEQUENCE; DNA PRIMERS; DOWN-REGULATION; MICE; MICE, KNOCKOUT; MICRORNAS; NF-KAPPA B P50 SUBUNIT; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84894559247     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.8     Document Type: Article

References (53)

1. Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003; 22: 9030-9040
2. Muller PA, Vousden KH, Norman JC. P53 and its mutants in tumor cell migration and invasion. J Cell Biol 2011; 192: 209-218
3. Teodoro JG, Parker AE, Zhu X, Green MR. P53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science 2006; 313: 968-971
4. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-Type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992; 70: 937-948
5. Bode AM, Dong Z. Post-Translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4: 793-805
6. Bosari S, Viale G, Roncalli M, Graziani D, Borsani G, Lee AK et al. P53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol 1995; 147: 790-798
7. Heinrichs S, Deppert W. Apoptosis or growth arrest: Modulation of the cellular response to p53 by proliferative signals. Oncogene 2003; 22: 555-571
8. Ryan KM, Phillips AC, Vousden KH. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 2001; 13: 332-337
9. Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 2005; 123: 49-63
10. Gebel TW. Arsenic and drinking water contamination. Science 1999; 283: 1458-1459
11. Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 1998; 339: 1341-1348
12. Zhang XW, Yan XJ, Zhou ZR, Yang FF, Wu ZY, Sun HB et al. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 2010; 328: 240-243
13. Yih LH, Lee TC. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. Cancer Res 2000; 60: 6346-6352
14. Lenardo MJ, Baltimore D. NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989; 58: 227-229
15. Yu Y, Wan Y, Huang C. The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target. Curr Cancer Drug Targets 2009; 9: 566-571
16. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002; 2: 725-734
17. Wang YJ, Wang JT, Fan QX, Geng JG. Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis. Cell Res 2007b; 17: 933-941
18. Song L, Li J, Zhang D, Liu ZG, Ye J, Zhan Q et al. IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol 2006; 175: 607-617
19. Maillet A, Pervaiz S. Redox regulation of p53, redox effectors regulated by p53: A subtle balance. Antioxid Redox Signal 2012; 16: 1285-1294
20. Xu Y. Regulation of p53 responses by post-Translational modifications. Cell Death Differ 2003; 10: 400-403
21. Fiaschi T, Chiarugi P. Oxidative stress, tumor microenvironment, and metabolic reprogramming: A diabolic liaison. Int J Cell Biol 2012; 2012: 8
22. Bellodi C, Kopmar N, Ruggero D. Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita. EMBO J 2010; 29: 1865-1876
23. Karawajew L, Rhein P, Czerwony G, Ludwig W-D. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood 2005; 105: 4767-4775
24. Ljungman M. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2000; 2: 208-225
25. Stahnke K, Fulda S, Friesen C, Strau G, Debatin K-M. Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy Blood 2001; 98: 3066-3073
26. Yang DQ, Halaby MJ, Zhang Y. The identification of an internal ribosomal entry site in the 5[prime]-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. Oncogene 2006; 25: 4613-4619
27. Peterson RT, Schreiber SL. Translation control: Connecting mitogens and the ribosome. Curr Biol 1998; 8: R248-R250
28. Hutchinson JA, Shanware NP, Chang H, Tibbetts RS. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J Biol Chem 2011; 286: 8688-8696
29. Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J et al. Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression. Cell Mol Life Sci 2011; 68: 475-488
30. Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasomemediated degradation. J Biol Chem 2001; 276: 993-998
31. Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 2000; 20: 5010-5018
32. Gao T, Furnari F, Newton AC. PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24
33. Quinn JE, Kennedy RD, Mullan PB, Gilmore PM, Carty M, Johnston PG et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003; 63: 6221-6228
34. Hellen CUT, Sarnow P. Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev 2001; 15: 1593-1612
35. Rossman TG, Klein CB. Genetic and epigenetic effects of environmental arsenicals. Metallomics 2011; 3: 1135-1141
36. Li J, Tang M-s, Liu B, Shi X, Huang C. A critical role of PI-3K//Akt//JNKs pathway in benzo[lsqb]a[rsqb]pyrene diol-epoxide (B[lsqb]a[rsqb]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene 2004; 23: 3932-3944
37. Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet 2007; 8: 93-103
38. Beezhold K, Liu J, Kan H, Meighan T, Castranova V, Shi X et al. miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. Toxicol Sci 2011; 123: 411-420
39. Chen A, Cao EH, Zhang TC, Qin JF. Arsenite-induced reactive oxygen species and the repression of alpha-Tocopherol in the MGC-803 cells. Eur J Pharmacol 2002; 448: 11-18
40. Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K et al. Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 2002; 277: 21843-21850
41. Xu D, Wilson TJ, Chan D, De Luca E, Zhou J, Hertzog PJ et al. Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J 2002; 21: 4081-4093
42. Yan W, Zhang Y, Zhang J, Liu S, Cho SJ, Chen X. Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J Biol Chem 2011; 286: 17478-17486
43. Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett 2002; 512: 334-340
44. Schuler M, Maurer U, Goldstein JC, Breitenbucher F, Hoffarth S, Waterhouse NJ et al. P53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation. Cell Death Differ 2003; 10: 451-460
45. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936
46. El-Deiry WS. The role of p53 in chemosensitivity and radiosensitivity. Oncogene 2003; 22: 7486-7495
47. Hinata N, Shirakawa T, Zhang Z, Matsumoto A, Fujisawa M, Okada H et al. Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-Type-p53 but not in p53-mutated bladder cancer cells. Urol Res 2003; 31: 387-396
48. Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T. Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis. Oncogene 2009; 28: 994-1004
49. Ying SY, Lin SL. Intron-derived microRNAs-fine tuning of gene functions. Gene 2004; 342: 25-28
50. Zheng H, Chu J, Zeng Y, Loh HH, Law PY. Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem 2010; 285: 21994-22002
51. Wang H, Hertlein E, Bakkar N, Sun H, Acharyya S, Wang J et al. NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol 2007a; 27: 4374-4387
52. Bellacosa A, Chan OT, Ahmed NN, Datta K, Malstrom S, Stokoe D et al. Akt activation by growth factors is a multiple-step process: The role of the PH domain. Oncogene 1998; 17: 313-325
53. Jiang B-H, Aoki M, Zheng JZ, Li J, Vogt PK. Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-Threonine kinase Akt/protein kinase B. Proc Natl Acad Sci 1999; 96: 2077-2081.