FOXO1-dependent DNA damage repair is regulated by JNK in lung cancer cells

International Journal of Oncology

Volumn 44, Issue 4, 2014, Pages 1284-1292

  Yinghua, J U ^a   Taojun, X U ^a   Zhang, Hongkai ^a   Aiming, Y U ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

DNA damage; FOXO1; JNK; Lung cancer; MNNG

Indexed keywords

ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; CDKN1B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; GADD45A PROTEIN, HUMAN; MEMBRANE PROTEIN; METHYLNITRONITROSOGUANIDINE; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANTHRACENES; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA DAMAGE; DNA REPAIR; FORKHEAD TRANSCRIPTION FACTORS; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MEMBRANE PROTEINS; METHYLNITRONITROSOGUANIDINE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84894459982     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2269     Document Type: Article

References (35)

1. Hoeijmakers JH: DNA damage, aging, and cancer. N Engl J Med 361: 1475-1485, 2009.
2. Sedgwick B, Bates PA, Paik J, Jacobs SC and Lindahl T: Repair of alkylated DNA: recent advances. DNA Repair 6: 429-442, 2007. (Pubitemid 46357047)
3. Maher RL, Branagan AM and Morrical SW: Coordination of DNA replication and recombination activities in the maintenance of genome stability. J Cell Biochem 112: 2672-2682, 2011.
4. Fu D, Calvo JA and Samson LD: Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12: 104-120, 2012.
5. Zhou BB and Elledge SJ: The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439, 2012.
6. Lam M, Carmichael AR and Griffiths HR: An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One 7: e40152, 2012.
7. Greer EL and Brunet A: FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24: 7410-7425, 2005. (Pubitemid 41637981)
8. Maiese K, Chong ZZ, Shang YC and Hou J: Clever cancer strategies with FoxO transcription factors. Cell Cycle 7: 3829-3839, 2008.
9. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang LW and Greenberg ME: DNA repair pathway stimulated by the Forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534, 2002. (Pubitemid 34408672)
10. Lei H and Quelle FW: FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage. Mol Cancer Res 7: 1294-1303, 2009.
11. de Keizer PL, Packer LM, Szypowska AA, Riedl-Polderman PE, van den Broek NJ, de Bruin A, Dansen TB, Marais R, Brenkman AB and Burgering BM: Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res 70: 8526-8536, 2010.
12. Huang H and Tindall DJ: Dynamic FoxO transcription factors. J Cell Sci 120: 2479-2487, 2007. (Pubitemid 47323857)
13. Yang JY and Hung MC: A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res 15: 752-757, 2009.
14. Vogt PK, Jiang H and Aoki M: Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 4: 908-913, 2005. (Pubitemid 41359756)
15. Rena G, Prescott AR, Guo S, Cohen P and Unterman TG: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting. Biochem J 354: 605-612, 2001. (Pubitemid 32269724)
16. Essers MA, Weijzen S, Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL and Burgering BM: FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23: 4802-4812, 2004. (Pubitemid 40069710)
17. Fu Z and Tindall DJ: FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312-2319, 2008. (Pubitemid 351501782)
18. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC and Sasaki YF: Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35: 206-221, 2000. (Pubitemid 30196665)
19. Dhawan A, Bajpayee M and Parmar D: Comet assay: a reliable tool for the assessment of DNA damage in different models. Cell Biol Toxicol 25: 5-32, 2009.
20. Drabløs F, Feyzi E, Aas PA, Vaagbø CB, Kavli B, Bratlie MS, Peña-Diaz J, Otterlei M, Slupphaug G and Krokan HE: Alkylation damage in DNA and RNA - repair mechanisms and medical significance. DNA Repair 3: 1389-1407, 2004. (Pubitemid 39221738)
21. Cok I, Ulutaş OK, Okuşluk O, Durmaz E and Demir N: Evaluation of DNA damage in common carp (Cyprinus carpio L.) by comet assay for determination of possible pollution in Lake Mogan (Ankara). Sci World J 11: 1455-1461, 2011.
22. Schroering AG and Williams KJ: Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment. DNA Repair 7: 951-969, 2008.
23. Jasin M: Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 21: 8981-8993, 2002.
24. Abraham RT: Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196, 2001.
25. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER III, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP and Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-1166, 2007. (Pubitemid 46877472)
26. Hirano M, Hirano K, Nishimura J and Kanaide H: Transcriptional up-regulation of p27 (Kip1) during contact-induced growth arrest in vascular endothelial cells. Exp Cell Res 271: 356-367, 2001. (Pubitemid 33141217)
27. Hildesheim J and Fornace AJ Jr: Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer. Clin Cancer Res 8: 2475-2479, 2002. (Pubitemid 34856328)
28. Kip1 and Bim in response to IL-2. J Immunol 168: 5024-5031, 2002.
29. Nakamura T and Sakamoto K: Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol Cell Endocrinol 281: 47-55, 2008. (Pubitemid 350296601)
30. Maiese K, Chong ZZ, Hou J and Shang YC: The 'O' class: crafting clinical care with FoxO transcription factors. Adv Exp Med Biol 665: 242-260, 2009.
31. Matsuzaki H, Daitoku H, Hatta M, Tanaka K and Fukamizu A: Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci USA 100: 11285-11290, 2003. (Pubitemid 37205927)
32. Davis RJ: Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252, 2000.
33. Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W and Kahl R: The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity. Carcinogenesis 29: 2045-2052, 2008.
34. Wang MC, Bohmann D and Jasper H: JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125, 2005.
35. Hong YK, Lee S, Park SH, Lee JH, Han SY, Kim ST, Kim YK, Jeon S, Koo BS and Cho KS: Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model. Biochem Biophys Res Commun 419: 49-53, 2012.