-
1
-
-
0032563825
-
Doxorubicin-induced cardiomyopathy
-
Singal,P.K. et al. (1998) Doxorubicin-induced cardiomyopathy. N. Engl. J. Med., 339, 900-905.
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 900-905
-
-
Singal, P.K.1
-
2
-
-
0033006172
-
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
-
Gewirtz,D.A. (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol., 57, 727-741.
-
(1999)
Biochem. Pharmacol
, vol.57
, pp. 727-741
-
-
Gewirtz, D.A.1
-
3
-
-
34247555971
-
Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage
-
Navarro,R. et al. (2006) Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage. Ann. N. Y. Acad. Sci., 1090, 408-418.
-
(2006)
Ann. N. Y. Acad. Sci
, vol.1090
, pp. 408-418
-
-
Navarro, R.1
-
4
-
-
33847121248
-
Downregulation of NF-kappaB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis
-
Chovolou,Y. et al. (2007) Downregulation of NF-kappaB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232, 89-98.
-
(2007)
Toxicology
, vol.232
, pp. 89-98
-
-
Chovolou, Y.1
-
5
-
-
2942616456
-
Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. Intermediacy of H(2)O(2)- and p53-dependent pathways
-
Wang,S. et al. (2004) Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. Intermediacy of H(2)O(2)- and p53-dependent pathways. J. Biol. Chem., 279, 25535-25543.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 25535-25543
-
-
Wang, S.1
-
6
-
-
36849015047
-
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
-
Yu,H.G. et al. (2007) Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int. J. Cancer, 122, 433-443.
-
(2007)
Int. J. Cancer
, vol.122
, pp. 433-443
-
-
Yu, H.G.1
-
7
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa,J.R. et al. (2001) AKT plays a central role in tumorigenesis. Proc. Natl Acad. Sci. USA, 98, 10983-10985.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
-
8
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning,B.D. et al. (2007) AKT/PKB signaling: Navigating downstream. Cell, 129, 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
-
9
-
-
34547838420
-
PTEN, more than the AKT pathway
-
Blanco-Aparicio,C. et al. (2007) PTEN, more than the AKT pathway. Carcinogenesis, 28, 1379-1386.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1379-1386
-
-
Blanco-Aparicio, C.1
-
10
-
-
34447335880
-
-
O Wan,X. et al. (2007) PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. Int. J. Gynecol. Cancer, 17, 808-812.
-
O Wan,X. et al. (2007) PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. Int. J. Gynecol. Cancer, 17, 808-812.
-
-
-
-
11
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
van der, H.A. et al. (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol., 8, 440-450.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 440-450
-
-
van der, H.A.1
-
12
-
-
21644470770
-
A forkhead in the road th longevity: The molecular basis of lifespan becomes clearer
-
Morris,B.J. (2005) A forkhead in the road th longevity: The molecular basis of lifespan becomes clearer. J. Hypetens., 23, 1285-1309.
-
(2005)
J. Hypetens
, vol.23
, pp. 1285-1309
-
-
Morris, B.J.1
-
13
-
-
37349055042
-
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
-
Kampkotter,A. et al. (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp. Biochem. Physiol. B. Biochem. Mol. Biol., 149, 314-323.
-
(2008)
Comp. Biochem. Physiol. B. Biochem. Mol. Biol
, vol.149
, pp. 314-323
-
-
Kampkotter, A.1
-
14
-
-
35348852474
-
The role of Forkhead-box class O (FoXO) transcription factors in cancer: A target for the management of cancer
-
Reagan-Shaw,S. et al. (2007) The role of Forkhead-box class O (FoXO) transcription factors in cancer: A target for the management of cancer. Toxicol. Appl. Pharmacol., 224, 360-368.
-
(2007)
Toxicol. Appl. Pharmacol
, vol.224
, pp. 360-368
-
-
Reagan-Shaw, S.1
-
15
-
-
33747370384
-
Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
-
Arden,K.C. (2006) Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp. Gerontol., 41, 709-717.
-
(2006)
Exp. Gerontol
, vol.41
, pp. 709-717
-
-
Arden, K.C.1
-
16
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik,J.H. et al. (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell, 128, 309-323.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
-
17
-
-
16644382513
-
Human FOX gene family (review)
-
Katoh,M. et al. (2004) Human FOX gene family (review). Int. J. Oncol., 25, 1495-1500.
-
(2004)
Int. J. Oncol
, vol.25
, pp. 1495-1500
-
-
Katoh, M.1
-
18
-
-
34548289502
-
Dynamic FoxO transcription factors
-
Huang,H. et al. (2007) Dynamic FoxO transcription factors. J. Cell Sci., 120, 2479-2487.
-
(2007)
J. Cell Sci
, vol.120
, pp. 2479-2487
-
-
Huang, H.1
-
19
-
-
28244483928
-
Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved am ng the FOXO family
-
Matsuzaki,H. et al. (2005) Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved am ng the FOXO family. J. Biochem. (Tokyo), 138, 485-491.
-
(2005)
J. Biochem. (Tokyo)
, vol.138
, pp. 485-491
-
-
Matsuzaki, H.1
-
20
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers,M.A. et al. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-4812.
-
(2004)
EMBO J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
-
21
-
-
34147162338
-
Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates
-
Li,S. et al. (2007) Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol. Cancer Ther., 6, 1031-1038.
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 1031-1038
-
-
Li, S.1
-
22
-
-
34247606468
-
Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis
-
Alexia,C. et al. (2006) Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis. Ann. N. Y. Acad. Sci., 1090, 1-17.
-
(2006)
Ann. N. Y. Acad. Sci
, vol.1090
, pp. 1-17
-
-
Alexia, C.1
-
23
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann,T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
24
-
-
41749092315
-
Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha
-
Lupertz,R. et al. (2007) Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha. J. Cell Biochem, 103, 1497-1511.
-
(2007)
J. Cell Biochem
, vol.103
, pp. 1497-1511
-
-
Lupertz, R.1
-
25
-
-
43349097382
-
Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone
-
Dorn,S.B. et al. (2008) Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. Arch. Toxicol., 82, 257-263.
-
(2008)
Arch. Toxicol
, vol.82
, pp. 257-263
-
-
Dorn, S.B.1
-
26
-
-
2342445654
-
Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation
-
Fukuoka,M. et al. (2003) Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int. J. Mol. Med., 12, 503-508.
-
(2003)
Int. J. Mol. Med
, vol.12
, pp. 503-508
-
-
Fukuoka, M.1
-
27
-
-
0347093421
-
Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway
-
Takeuchi,K. et al. (2004) Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway. J. Biol. Chem., 279, 892-900.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 892-900
-
-
Takeuchi, K.1
-
28
-
-
0030713362
-
Anthracyclines in the treatment of cancer. An overview
-
Hortobagyi,G.N. (1997) Anthracyclines in the treatment of cancer. An overview. Drugs, 54 (suppl 4), 1-7.
-
(1997)
Drugs
, vol.54
, Issue.SUPPL. 4
, pp. 1-7
-
-
Hortobagyi, G.N.1
-
29
-
-
0042526079
-
Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression - a special role for endothelial cells
-
Rittierodt,M. et al. (2003) Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression - a special role for endothelial cells. Exp. Toxicol. Pathol., 55, 39-44.
-
(2003)
Exp. Toxicol. Pathol
, vol.55
, pp. 39-44
-
-
Rittierodt, M.1
-
30
-
-
11844305621
-
Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute rhyeloid leukemic HL-60 cells
-
Puhlmann,U. et al. (2005) Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute rhyeloid leukemic HL-60 cells. J. Pharmacol. Exp., Ther., 312, 346-354.
-
(2005)
J. Pharmacol. Exp., Ther
, vol.312
, pp. 346-354
-
-
Puhlmann, U.1
-
31
-
-
0033834523
-
Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis
-
Kuninaka,S. et al. (2000) Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis. Br. J. Cancer, 83, 928-934.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 928-934
-
-
Kuninaka, S.1
-
32
-
-
33745312299
-
Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo
-
Ueno,M. et al. (2006) Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. J. Pharmacol. Sci., 101, 151-158.
-
(2006)
J. Pharmacol. Sci
, vol.101
, pp. 151-158
-
-
Ueno, M.1
-
33
-
-
22544466964
-
Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium
-
Kalivendi,S.V. et al. (2005) Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium. Biochem. J., 389, 527-539.
-
(2005)
Biochem. J
, vol.389
, pp. 527-539
-
-
Kalivendi, S.V.1
-
34
-
-
0033583191
-
Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs
-
Micheau,O. et al. (1999) Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J. Biol. Chem., 274, 7987-7992.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 7987-7992
-
-
Micheau, O.1
-
35
-
-
23744440681
-
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
-
Wagner,B.A. et al. (2005) Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch. Biochem. Biophys., 440, 181-190.
-
(2005)
Arch. Biochem. Biophys
, vol.440
, pp. 181-190
-
-
Wagner, B.A.1
-
36
-
-
33644865024
-
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
-
Kawamori,D. et al. (2006) The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J. Biol. Chem., 281, 1091-1098.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1091-1098
-
-
Kawamori, D.1
-
37
-
-
3843074548
-
Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcirroma. cells
-
Zhao,Y. et al. (2004) Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcirroma. cells. J. Cell. Biochem., 91, 621-632.
-
(2004)
J. Cell. Biochem
, vol.91
, pp. 621-632
-
-
Zhao, Y.1
-
38
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer,E.L. et al. (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24 7410-7425.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
-
39
-
-
33644875104
-
Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells
-
Li,X. et al. (2005) Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. Breast Cancer Res., 7, R589-R597.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Li, X.1
|