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Volumn 29, Issue 11, 2008, Pages 2045-2052

The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DNA; DOXORUBICIN; FORKHEAD TRANSCRIPTION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

EID: 56049096242     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn184     Document Type: Article
Times cited : (28)

References (39)
  • 1
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • Singal,P.K. et al. (1998) Doxorubicin-induced cardiomyopathy. N. Engl. J. Med., 339, 900-905.
    • (1998) N. Engl. J. Med , vol.339 , pp. 900-905
    • Singal, P.K.1
  • 2
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • Gewirtz,D.A. (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol., 57, 727-741.
    • (1999) Biochem. Pharmacol , vol.57 , pp. 727-741
    • Gewirtz, D.A.1
  • 3
    • 34247555971 scopus 로고    scopus 로고
    • Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage
    • Navarro,R. et al. (2006) Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage. Ann. N. Y. Acad. Sci., 1090, 408-418.
    • (2006) Ann. N. Y. Acad. Sci , vol.1090 , pp. 408-418
    • Navarro, R.1
  • 4
    • 33847121248 scopus 로고    scopus 로고
    • Downregulation of NF-kappaB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis
    • Chovolou,Y. et al. (2007) Downregulation of NF-kappaB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232, 89-98.
    • (2007) Toxicology , vol.232 , pp. 89-98
    • Chovolou, Y.1
  • 5
    • 2942616456 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. Intermediacy of H(2)O(2)- and p53-dependent pathways
    • Wang,S. et al. (2004) Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. Intermediacy of H(2)O(2)- and p53-dependent pathways. J. Biol. Chem., 279, 25535-25543.
    • (2004) J. Biol. Chem , vol.279 , pp. 25535-25543
    • Wang, S.1
  • 6
    • 36849015047 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
    • Yu,H.G. et al. (2007) Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int. J. Cancer, 122, 433-443.
    • (2007) Int. J. Cancer , vol.122 , pp. 433-443
    • Yu, H.G.1
  • 7
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumorigenesis
    • Testa,J.R. et al. (2001) AKT plays a central role in tumorigenesis. Proc. Natl Acad. Sci. USA, 98, 10983-10985.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10983-10985
    • Testa, J.R.1
  • 8
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning,B.D. et al. (2007) AKT/PKB signaling: Navigating downstream. Cell, 129, 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1
  • 9
    • 34547838420 scopus 로고    scopus 로고
    • PTEN, more than the AKT pathway
    • Blanco-Aparicio,C. et al. (2007) PTEN, more than the AKT pathway. Carcinogenesis, 28, 1379-1386.
    • (2007) Carcinogenesis , vol.28 , pp. 1379-1386
    • Blanco-Aparicio, C.1
  • 10
    • 34447335880 scopus 로고    scopus 로고
    • O Wan,X. et al. (2007) PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. Int. J. Gynecol. Cancer, 17, 808-812.
    • O Wan,X. et al. (2007) PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. Int. J. Gynecol. Cancer, 17, 808-812.
  • 11
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • van der, H.A. et al. (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol., 8, 440-450.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 440-450
    • van der, H.A.1
  • 12
    • 21644470770 scopus 로고    scopus 로고
    • A forkhead in the road th longevity: The molecular basis of lifespan becomes clearer
    • Morris,B.J. (2005) A forkhead in the road th longevity: The molecular basis of lifespan becomes clearer. J. Hypetens., 23, 1285-1309.
    • (2005) J. Hypetens , vol.23 , pp. 1285-1309
    • Morris, B.J.1
  • 13
    • 37349055042 scopus 로고    scopus 로고
    • Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
    • Kampkotter,A. et al. (2008) Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp. Biochem. Physiol. B. Biochem. Mol. Biol., 149, 314-323.
    • (2008) Comp. Biochem. Physiol. B. Biochem. Mol. Biol , vol.149 , pp. 314-323
    • Kampkotter, A.1
  • 14
    • 35348852474 scopus 로고    scopus 로고
    • The role of Forkhead-box class O (FoXO) transcription factors in cancer: A target for the management of cancer
    • Reagan-Shaw,S. et al. (2007) The role of Forkhead-box class O (FoXO) transcription factors in cancer: A target for the management of cancer. Toxicol. Appl. Pharmacol., 224, 360-368.
    • (2007) Toxicol. Appl. Pharmacol , vol.224 , pp. 360-368
    • Reagan-Shaw, S.1
  • 15
    • 33747370384 scopus 로고    scopus 로고
    • Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    • Arden,K.C. (2006) Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp. Gerontol., 41, 709-717.
    • (2006) Exp. Gerontol , vol.41 , pp. 709-717
    • Arden, K.C.1
  • 16
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik,J.H. et al. (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell, 128, 309-323.
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1
  • 17
    • 16644382513 scopus 로고    scopus 로고
    • Human FOX gene family (review)
    • Katoh,M. et al. (2004) Human FOX gene family (review). Int. J. Oncol., 25, 1495-1500.
    • (2004) Int. J. Oncol , vol.25 , pp. 1495-1500
    • Katoh, M.1
  • 18
    • 34548289502 scopus 로고    scopus 로고
    • Dynamic FoxO transcription factors
    • Huang,H. et al. (2007) Dynamic FoxO transcription factors. J. Cell Sci., 120, 2479-2487.
    • (2007) J. Cell Sci , vol.120 , pp. 2479-2487
    • Huang, H.1
  • 19
    • 28244483928 scopus 로고    scopus 로고
    • Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved am ng the FOXO family
    • Matsuzaki,H. et al. (2005) Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved am ng the FOXO family. J. Biochem. (Tokyo), 138, 485-491.
    • (2005) J. Biochem. (Tokyo) , vol.138 , pp. 485-491
    • Matsuzaki, H.1
  • 20
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers,M.A. et al. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-4812.
    • (2004) EMBO J , vol.23 , pp. 4802-4812
    • Essers, M.A.1
  • 21
    • 34147162338 scopus 로고    scopus 로고
    • Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates
    • Li,S. et al. (2007) Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol. Cancer Ther., 6, 1031-1038.
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1031-1038
    • Li, S.1
  • 22
    • 34247606468 scopus 로고    scopus 로고
    • Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis
    • Alexia,C. et al. (2006) Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis. Ann. N. Y. Acad. Sci., 1090, 1-17.
    • (2006) Ann. N. Y. Acad. Sci , vol.1090 , pp. 1-17
    • Alexia, C.1
  • 23
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann,T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 24
    • 41749092315 scopus 로고    scopus 로고
    • Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha
    • Lupertz,R. et al. (2007) Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha. J. Cell Biochem, 103, 1497-1511.
    • (2007) J. Cell Biochem , vol.103 , pp. 1497-1511
    • Lupertz, R.1
  • 25
    • 43349097382 scopus 로고    scopus 로고
    • Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone
    • Dorn,S.B. et al. (2008) Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. Arch. Toxicol., 82, 257-263.
    • (2008) Arch. Toxicol , vol.82 , pp. 257-263
    • Dorn, S.B.1
  • 26
    • 2342445654 scopus 로고    scopus 로고
    • Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation
    • Fukuoka,M. et al. (2003) Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int. J. Mol. Med., 12, 503-508.
    • (2003) Int. J. Mol. Med , vol.12 , pp. 503-508
    • Fukuoka, M.1
  • 27
    • 0347093421 scopus 로고    scopus 로고
    • Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway
    • Takeuchi,K. et al. (2004) Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway. J. Biol. Chem., 279, 892-900.
    • (2004) J. Biol. Chem , vol.279 , pp. 892-900
    • Takeuchi, K.1
  • 28
    • 0030713362 scopus 로고    scopus 로고
    • Anthracyclines in the treatment of cancer. An overview
    • Hortobagyi,G.N. (1997) Anthracyclines in the treatment of cancer. An overview. Drugs, 54 (suppl 4), 1-7.
    • (1997) Drugs , vol.54 , Issue.SUPPL. 4 , pp. 1-7
    • Hortobagyi, G.N.1
  • 29
    • 0042526079 scopus 로고    scopus 로고
    • Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression - a special role for endothelial cells
    • Rittierodt,M. et al. (2003) Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression - a special role for endothelial cells. Exp. Toxicol. Pathol., 55, 39-44.
    • (2003) Exp. Toxicol. Pathol , vol.55 , pp. 39-44
    • Rittierodt, M.1
  • 30
    • 11844305621 scopus 로고    scopus 로고
    • Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute rhyeloid leukemic HL-60 cells
    • Puhlmann,U. et al. (2005) Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute rhyeloid leukemic HL-60 cells. J. Pharmacol. Exp., Ther., 312, 346-354.
    • (2005) J. Pharmacol. Exp., Ther , vol.312 , pp. 346-354
    • Puhlmann, U.1
  • 31
    • 0033834523 scopus 로고    scopus 로고
    • Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis
    • Kuninaka,S. et al. (2000) Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis. Br. J. Cancer, 83, 928-934.
    • (2000) Br. J. Cancer , vol.83 , pp. 928-934
    • Kuninaka, S.1
  • 32
    • 33745312299 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo
    • Ueno,M. et al. (2006) Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. J. Pharmacol. Sci., 101, 151-158.
    • (2006) J. Pharmacol. Sci , vol.101 , pp. 151-158
    • Ueno, M.1
  • 33
    • 22544466964 scopus 로고    scopus 로고
    • Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium
    • Kalivendi,S.V. et al. (2005) Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium. Biochem. J., 389, 527-539.
    • (2005) Biochem. J , vol.389 , pp. 527-539
    • Kalivendi, S.V.1
  • 34
    • 0033583191 scopus 로고    scopus 로고
    • Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs
    • Micheau,O. et al. (1999) Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J. Biol. Chem., 274, 7987-7992.
    • (1999) J. Biol. Chem , vol.274 , pp. 7987-7992
    • Micheau, O.1
  • 35
    • 23744440681 scopus 로고    scopus 로고
    • Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
    • Wagner,B.A. et al. (2005) Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch. Biochem. Biophys., 440, 181-190.
    • (2005) Arch. Biochem. Biophys , vol.440 , pp. 181-190
    • Wagner, B.A.1
  • 36
    • 33644865024 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    • Kawamori,D. et al. (2006) The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J. Biol. Chem., 281, 1091-1098.
    • (2006) J. Biol. Chem , vol.281 , pp. 1091-1098
    • Kawamori, D.1
  • 37
    • 3843074548 scopus 로고    scopus 로고
    • Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcirroma. cells
    • Zhao,Y. et al. (2004) Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcirroma. cells. J. Cell. Biochem., 91, 621-632.
    • (2004) J. Cell. Biochem , vol.91 , pp. 621-632
    • Zhao, Y.1
  • 38
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer,E.L. et al. (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene, 24 7410-7425.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1
  • 39
    • 33644875104 scopus 로고    scopus 로고
    • Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells
    • Li,X. et al. (2005) Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. Breast Cancer Res., 7, R589-R597.
    • (2005) Breast Cancer Res , vol.7
    • Li, X.1


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