A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats

Addiction Biology

Volumn 19, Issue 2, 2014, Pages 195-209

  Keck, Thomas M ^a   Zou, Mu Fa ^a   Bi, Guo Hua ^a   Zhang, Hai Ying ^a   Wang, Xiao Fei ^a   Yang, Hong Ju ^a   Srivastava, Ratika ^a   Gardner, Eliot L ^a   Xi, Zheng Xiong ^a   Newman, Amy Hauck ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Cocaine; cue induced cocaine seeking; MFZ 10 7; mGluR5; MTEP; reinstatement; self administration; sucrose

Indexed keywords

3-((2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL)PIPERIDINE; 3-FLUORO-5-((6-METHYLPYRIDIN-2-YL)ETHYNYL)BENZONITRILE; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; COCAINE; DOPAMINE UPTAKE INHIBITOR; FENOBAM; IMIDAZOLE DERIVATIVE; METABOTROPIC RECEPTOR 5; NITRILE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SUCROSE; THIAZOLE DERIVATIVE;

ALLOSTERISM; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; ASSOCIATION; BINDING COMPETITION; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEK293 CELL LINE; HUMAN; IC50; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; PHYSIOLOGY; RANDOMIZATION; RAT; REINFORCEMENT; REWARD; SECONDARY PREVENTION;

ALLOSTERIC REGULATION; ANALYSIS OF VARIANCE; ANIMALS; BINDING, COMPETITIVE; COCAINE; CUES; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID ANTAGONISTS; HEK293 CELLS; HUMANS; IMIDAZOLES; IN VITRO TECHNIQUES; INFUSIONS, INTRAVENOUS; INHIBITORY CONCENTRATION 50; MALE; MOTOR ACTIVITY; NITRILES; PIPERIDINES; PYRIDINES; RANDOM ALLOCATION; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; REINFORCEMENT SCHEDULE; REWARD; SECONDARY PREVENTION; SELF ADMINISTRATION; SUCROSE; THIAZOLES;

EID: 84894420086     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12086     Document Type: Article

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