-
1
-
-
33645025726
-
Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking
-
16123768 10.1038/sj.npp.1300845
-
Bäckström P, Hyytiä P (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31:778-786
-
(2006)
Neuropsychopharmacology
, vol.31
, pp. 778-786
-
-
Bäckström, P.1
Hyytiä, P.2
-
2
-
-
34249883314
-
Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats
-
17347848 10.1007/s00213-007-0753-8
-
Backstrom P, Hyytia P (2007) Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology 192:571-580
-
(2007)
Psychopharmacology
, vol.192
, pp. 571-580
-
-
Backstrom, P.1
Hyytia, P.2
-
3
-
-
84877146706
-
The behavioral economics of drug self-administration: A review and new analytical approach for within-session procedures
-
23086021 10.1007/s00213-012-2899-2 1:CAS:528:DC%2BC38XhsFCjsb3F
-
Bentzley BS, Fender KM, Aston-Jones G (2013) The behavioral economics of drug self-administration: a review and new analytical approach for within-session procedures. Psychopharmacology 226:113-125
-
(2013)
Psychopharmacology
, vol.226
, pp. 113-125
-
-
Bentzley, B.S.1
Fender, K.M.2
Aston-Jones, G.3
-
4
-
-
65949096495
-
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
-
19126569 10.1136/jmg.2008.063701 1:CAS:528:DC%2BD1MXlt1Git7c%3D
-
Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchison J, Snape M, Tranfaglia M, Nguyen DV, Hagerman R (2009) A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet 46:266-271
-
(2009)
J Med Genet
, vol.46
, pp. 266-271
-
-
Berry-Kravis, E.1
Hessl, D.2
Coffey, S.3
Hervey, C.4
Schneider, A.5
Yuhas, J.6
Hutchison, J.7
Snape, M.8
Tranfaglia, M.9
Nguyen, D.V.10
Hagerman, R.11
-
5
-
-
20144364615
-
Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice
-
15590770 10.1124/jpet.104.076406 1:CAS:528:DC%2BD2MXjtlSntrc%3D
-
Bradbury MJ, Campbell U, Giracello D, Chapman D, King C, Tehrani L, Cosford ND, Anderson J, Varney MA, Strack AM (2005) Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J Pharmacol Exp Ther 313:395-402
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 395-402
-
-
Bradbury, M.J.1
Campbell, U.2
Giracello, D.3
Chapman, D.4
King, C.5
Tehrani, L.6
Cosford, N.D.7
Anderson, J.8
Varney, M.A.9
Strack, A.M.10
-
6
-
-
55049123814
-
Antagonists at metabotropic glutamate receptor subtype 5: Structure activity relationships and therapeutic potential for addiction
-
18991960 10.1196/annals.1441.015 1:CAS:528:DC%2BD1cXhsVOkt7bE
-
Carroll FI (2008) Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction. Ann N Y Acad Sci 1141:221-232
-
(2008)
Ann N y Acad Sci
, vol.1141
, pp. 221-232
-
-
Carroll, F.I.1
-
7
-
-
0034867765
-
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
-
11528416 10.1038/nn0901-873 1:CAS:528:DC%2BD3MXmtlaqurc%3D
-
Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S, Corsi M, Orzi F, Conquet F (2001) Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4:873-874
-
(2001)
Nat Neurosci
, vol.4
, pp. 873-874
-
-
Chiamulera, C.1
Epping-Jordan, M.P.2
Zocchi, A.3
Marcon, C.4
Cottiny, C.5
Tacconi, S.6
Corsi, M.7
Orzi, F.8
Conquet, F.9
-
8
-
-
84865984526
-
Differential modulation of thresholds for intracranial self-stimulation by mGlu5 positive and negative allosteric modulators: Implications for effects on drug self-administration
-
22232603 10.3389/fphar.2011.00093
-
Cleva RM, Watterson LR, Johnson MA, Olive MF (2012) Differential modulation of thresholds for intracranial self-stimulation by mGlu5 positive and negative allosteric modulators: implications for effects on drug self-administration. Front Pharmacol 2:93
-
(2012)
Front Pharmacol
, vol.2
, pp. 93
-
-
Cleva, R.M.1
Watterson, L.R.2
Johnson, M.A.3
Olive, M.F.4
-
9
-
-
0037448394
-
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
-
12519057 10.1021/jm025570j 1:CAS:528:DC%2BD38XpsVensLk%3D
-
Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA (2003) 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-206
-
(2003)
J Med Chem
, vol.46
, pp. 204-206
-
-
Cosford, N.D.1
Tehrani, L.2
Roppe, J.3
Schweiger, E.4
Smith, N.D.5
Anderson, J.6
Bristow, L.7
Brodkin, J.8
Jiang, X.9
McDonald, I.10
Rao, S.11
Washburn, M.12
Varney, M.A.13
-
10
-
-
33746867592
-
Effects of group i metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats
-
16896963 10.1007/s00213-006-0440-1 1:CAS:528:DC%2BD28XnvVymsr0%3D
-
Dravolina OA, Danysz W, Bespalov AY (2006) Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. Psychopharmacology 187:397-404
-
(2006)
Psychopharmacology
, vol.187
, pp. 397-404
-
-
Dravolina, O.A.1
Danysz, W.2
Bespalov, A.Y.3
-
12
-
-
0018877483
-
Phase II double blind controlled study of a new anxiolytic, fenobam (McN-3377) vs. placebo
-
Friedmann CTH, Davis LJ, Ciccone PE, Rubin RT (1980) Phase II double blind controlled study of a new anxiolytic, fenobam (McN-3377) vs. placebo. Curr Ther Res 27:144-151
-
(1980)
Curr Ther Res
, vol.27
, pp. 144-151
-
-
Friedmann, C.T.H.1
Davis, L.J.2
Ciccone, P.E.3
Rubin, R.T.4
-
13
-
-
0032853255
-
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
-
10530811 10.1016/S0028-3908(99)00082-9 1:CAS:528:DyaK1MXlvVWnsbw%3D
-
Gasparini F, Lingenhöhl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R (1999) 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38:1493-1503
-
(1999)
Neuropharmacology
, vol.38
, pp. 1493-1503
-
-
Gasparini, F.1
Lingenhöhl, K.2
Stoehr, N.3
Flor, P.J.4
Heinrich, M.5
Vranesic, I.6
Biollaz, M.7
Allgeier, H.8
Heckendorn, R.9
Urwyler, S.10
Varney, M.A.11
Johnson, E.C.12
Hess, S.D.13
Rao, S.P.14
Sacaan, A.I.15
Santori, E.M.16
Velicelebi, G.17
Kuhn, R.18
-
14
-
-
0022591327
-
Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations
-
3947206 10.1001/archpsyc.1986.01800020013003 1:STN:280: DyaL287ivFOltw%3D%3D
-
Gawin FH, Kleber HD (1986) Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations. Arch Gen Psychiatry 43:107-113
-
(1986)
Arch Gen Psychiatry
, vol.43
, pp. 107-113
-
-
Gawin, F.H.1
Kleber, H.D.2
-
15
-
-
2942525894
-
Inhibition of human hepatic CYP isoforms by mGluR5 antagonists
-
15193955 10.1016/j.lfs.2004.02.009 1:CAS:528:DC%2BD2cXkvVKqur0%3D
-
Green MD, Jiang X, King CD (2004) Inhibition of human hepatic CYP isoforms by mGluR5 antagonists. Life Sci 75:947-953
-
(2004)
Life Sci
, vol.75
, pp. 947-953
-
-
Green, M.D.1
Jiang, X.2
King, C.D.3
-
16
-
-
0035849890
-
Neuroadaptation. Incubation of cocaine craving after withdrawal
-
11449260 10.1038/35084134 1:CAS:528:DC%2BD3MXlsFWnsr0%3D
-
Grimm JW, Hope BT, Wise RA, Shaham Y (2001) Neuroadaptation. Incubation of cocaine craving after withdrawal. Nature 412:141-142
-
(2001)
Nature
, vol.412
, pp. 141-142
-
-
Grimm, J.W.1
Hope, B.T.2
Wise, R.A.3
Shaham, Y.4
-
17
-
-
0242653836
-
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo
-
14556231 10.1002/syn.10261 1:CAS:528:DC%2BD3sXovVyhtLk%3D
-
Heidbreder CA, Bianchi M, Lacroix LP, Faedo S, Perdona E, Remelli R, Cavanni P, Crespi F (2003) Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse 50:269-276
-
(2003)
Synapse
, vol.50
, pp. 269-276
-
-
Heidbreder, C.A.1
Bianchi, M.2
Lacroix, L.P.3
Faedo, S.4
Perdona, E.5
Remelli, R.6
Cavanni, P.7
Crespi, F.8
-
18
-
-
8844238423
-
Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine
-
15555632 10.1016/j.neuropharm.2004.07.037 1:CAS:528:DC%2BD2cXhtVSltLvM
-
Herzig V, Schmidt WJ (2004) Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine. Neuropharmacology 47:973-984
-
(2004)
Neuropharmacology
, vol.47
, pp. 973-984
-
-
Herzig, V.1
Schmidt, W.J.2
-
19
-
-
65649118524
-
Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: Comparisons with monoamine uptake inhibitors
-
19228996 10.1124/jpet.108.145813 1:CAS:528:DC%2BD1MXlt1Ols7o%3D
-
Hiranita T, Soto PL, Newman AH, Katz JL (2009) Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. J Pharmacol Exp Ther 329:677-686
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 677-686
-
-
Hiranita, T.1
Soto, P.L.2
Newman, A.H.3
Katz, J.L.4
-
20
-
-
0018241468
-
The clinical and quantitative EEG effects and plasma levels of fenobam (McN-3377) in subjects with anxiety: An open rising dose tolerance and efficacy study
-
Itil T, Seaman B, Huque M, Mukhopadhyay S, Blasucci D, Nq K, Ciccone P (1978) The clinical and quantitative EEG effects and plasma levels of fenobam (McN-3377) in subjects with anxiety: an open rising dose tolerance and efficacy study. Curr Ther Res 24:708-724
-
(1978)
Curr Ther Res
, vol.24
, pp. 708-724
-
-
Itil, T.1
Seaman, B.2
Huque, M.3
Mukhopadhyay, S.4
Blasucci, D.5
Nq, K.6
Ciccone, P.7
-
21
-
-
0038325744
-
From morphine clinics to buprenorphine: Regulating opioid agonist treatment of addiction in the United States
-
12738346 10.1016/S0376-8716(03)00055-3
-
Jaffe JH, O'Keeffe C (2003) From morphine clinics to buprenorphine: regulating opioid agonist treatment of addiction in the United States. Drug Alcohol Depend 70:S3-S11
-
(2003)
Drug Alcohol Depend
, vol.70
-
-
Jaffe, J.H.1
O'Keeffe, C.2
-
22
-
-
80053131013
-
New medications for drug addiction hiding in glutamatergic neuroplasticity
-
21519339 10.1038/mp.2011.46 1:CAS:528:DC%2BC3MXht1CltrbI
-
Kalivas PW, Volkow ND (2011) New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16:974-986
-
(2011)
Mol Psychiatry
, vol.16
, pp. 974-986
-
-
Kalivas, P.W.1
Volkow, N.D.2
-
23
-
-
17744400697
-
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
-
15602687 10.1007/s00213-004-2069-2 1:CAS:528:DC%2BD2MXjtV2it7c%3D
-
Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A (2005) Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology 179:247-254
-
(2005)
Psychopharmacology
, vol.179
, pp. 247-254
-
-
Kenny, P.J.1
Boutrel, B.2
Gasparini, F.3
Koob, G.F.4
Markou, A.5
-
24
-
-
59349110023
-
Glutamate and reinstatement
-
19157986 10.1016/j.coph.2008.12.003 1:CAS:528:DC%2BD1MXhsFKks78%3D
-
Knackstedt LA, Kalivas PW (2009) Glutamate and reinstatement. Curr Opin Pharmacol 9:59-64
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 59-64
-
-
Knackstedt, L.A.1
Kalivas, P.W.2
-
25
-
-
65549145853
-
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
-
19463707 10.1016/j.bbr.2009.03.039 1:CAS:528:DC%2BD1MXmtlelu78%3D
-
Kumaresan V, Yuan M, Yee J, Famous KR, Anderson SM, Schmidt HD, Pierce RC (2009) Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res 202:238-244
-
(2009)
Behav Brain Res
, vol.202
, pp. 238-244
-
-
Kumaresan, V.1
Yuan, M.2
Yee, J.3
Famous, K.R.4
Anderson, S.M.5
Schmidt, H.D.6
Pierce, R.C.7
-
26
-
-
33748062344
-
Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP
-
16958988 10.1111/j.1527-3458.2006.00149.x 1:CAS:528:DC%2BD28XpvVeiur0%3D
-
Lea PM, Faden AI (2006) Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev 12:149-166
-
(2006)
CNS Drug Rev
, vol.12
, pp. 149-166
-
-
Lea, P.M.1
Faden, A.I.2
-
27
-
-
14344261021
-
Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: Comparison with dizocilpine
-
15550570 10.1124/jpet.104.078733 1:CAS:528:DC%2BD2MXitVOgs7s%3D
-
Lee B, Platt DM, Rowlett JK, Adewale AS, Spealman RD (2005) Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J Pharmacol Exp Ther 312:1232-1240
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 1232-1240
-
-
Lee, B.1
Platt, D.M.2
Rowlett, J.K.3
Adewale, A.S.4
Spealman, R.D.5
-
28
-
-
67649992440
-
Recent progress in the discovery and development of negative allosteric modulators of mGluR5
-
19562641 1:CAS:528:DC%2BD1MXhsVClsbvJ
-
Lindsley CW, Emmitte KA (2009) Recent progress in the discovery and development of negative allosteric modulators of mGluR5. Curr Opin Drug Discov Devel 12:446-457
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 446-457
-
-
Lindsley, C.W.1
Emmitte, K.A.2
-
29
-
-
4644368826
-
Incubation of cocaine craving after withdrawal: A review of preclinical data
-
15464139 10.1016/j.neuropharm.2004.06.027 1:CAS:528:DC%2BD2cXotF2ht7w%3D
-
Lu L, Grimm JW, Hope BT, Shaham Y (2004) Incubation of cocaine craving after withdrawal: a review of preclinical data. Neuropharmacology 47(Suppl 1):214-226
-
(2004)
Neuropharmacology
, vol.47
, Issue.SUPPL. 1
, pp. 214-226
-
-
Lu, L.1
Grimm, J.W.2
Hope, B.T.3
Shaham, Y.4
-
30
-
-
34249869292
-
Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats
-
17361394 10.1007/s00213-007-0754-7 1:CAS:528:DC%2BD2sXmtVGisr0%3D
-
Mantsch JR, Li SJ, Risinger R, Awad S, Katz E, Baker DA, Yang Z (2007) Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats. Psychopharmacology 192:581-591
-
(2007)
Psychopharmacology
, vol.192
, pp. 581-591
-
-
Mantsch, J.R.1
Li, S.J.2
Risinger, R.3
Awad, S.4
Katz, E.5
Baker, D.A.6
Yang, Z.7
-
31
-
-
66749130963
-
Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]piperidine] on conditioned reinstatement and reinforcement: Comparison between cocaine and a conventional reinforcer
-
19258516 10.1124/jpet.109.151357 1:CAS:528:DC%2BD1MXms1egsr8%3D
-
Martin-Fardon R, Baptista MA, Dayas CV, Weiss F (2009) Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. J Pharmacol Exp Ther 329:1084-1090
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 1084-1090
-
-
Martin-Fardon, R.1
Baptista, M.A.2
Dayas, C.V.3
Weiss, F.4
-
32
-
-
84860243867
-
(-)-2-Oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking
-
21790902 10.1111/j.1369-1600.2011.00345.x 1:CAS:528:DC%2BC38XnsVSltLc%3D
-
Martin-Fardon R, Weiss F (2012) (-)-2-Oxa-4-aminobicylco[3.1.0]hexane-4, 6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl] piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. Addict Biol 17:557-564
-
(2012)
Addict Biol
, vol.17
, pp. 557-564
-
-
Martin-Fardon, R.1
Weiss, F.2
-
33
-
-
0037363728
-
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP
-
12684257 10.1038/sj.bjp.0705159 1:CAS:528:DC%2BD3sXjtVahsLc%3D
-
Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138:1026-1030
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1026-1030
-
-
Mathiesen, J.M.1
Svendsen, N.2
Bräuner-Osborne, H.3
Thomsen, C.4
Ramirez, M.T.5
-
34
-
-
0037693859
-
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior
-
12716962 1:CAS:528:DC%2BD3sXjsFSktLc%3D
-
McFarland K, Lapish CC, Kalivas PW (2003) Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 23:3531-3537
-
(2003)
J Neurosci
, vol.23
, pp. 3531-3537
-
-
McFarland, K.1
Lapish, C.C.2
Kalivas, P.W.3
-
35
-
-
3142737454
-
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
-
14726993 10.1007/s00213-003-1733-2 1:CAS:528:DC%2BD2cXltVSntbs%3D
-
McGeehan AJ, Janak PH, Olive MF (2004) Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology 174:266-273
-
(2004)
Psychopharmacology
, vol.174
, pp. 266-273
-
-
McGeehan, A.J.1
Janak, P.H.2
Olive, M.F.3
-
36
-
-
0037337238
-
The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse
-
12494407 10.1002/syn.10166 1:CAS:528:DC%2BD3sXptVCnug%3D%3D
-
McGeehan AJ, Olive MF (2003) The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse 47:240-242
-
(2003)
Synapse
, vol.47
, pp. 240-242
-
-
McGeehan, A.J.1
Olive, M.F.2
-
37
-
-
38349120971
-
Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: A time course microdialysis study
-
Miguéns M, Del Olmo N, Higuera-Matas A, Torres I, García-Lecumberri C, Ambrosio E (2008) Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: a time course microdialysis study. Psychopharmacology 196:303-313
-
(2008)
Psychopharmacology
, vol.196
, pp. 303-313
-
-
Miguéns, M.D.1
-
38
-
-
46549086736
-
Subcellular and subsynaptic localization of group i metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats
-
18479833 10.1016/j.neuroscience.2008.03.049 1:CAS:528: DC%2BD1cXnt1ems7g%3D
-
Mitrano DA, Arnold C, Smith Y (2008) Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats. Neuroscience 154:653-666
-
(2008)
Neuroscience
, vol.154
, pp. 653-666
-
-
Mitrano, D.A.1
Arnold, C.2
Smith, Y.3
-
39
-
-
33846145400
-
Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey
-
17154259 10.1002/cne.21214 1:CAS:528:DC%2BD2sXhtVWht7g%3D
-
Mitrano DA, Smith Y (2007) Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey. J Comp Neurol 500:788-806
-
(2007)
J Comp Neurol
, vol.500
, pp. 788-806
-
-
Mitrano, D.A.1
Smith, Y.2
-
40
-
-
70349260680
-
The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine
-
19515968 10.1124/jpet.109.154138 1:CAS:528:DC%2BD1MXhtVyitLzK
-
Montana MC, Cavallone LF, Stubbert KK, Stefanescu AD, Kharasch ED, Gereau RW IV (2009) The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. J Pharmacol Exp Ther 330:834-843
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 834-843
-
-
Montana, M.C.1
Cavallone, L.F.2
Stubbert, K.K.3
Stefanescu, A.D.4
Kharasch, E.D.5
Gereau, R.W.I.V.6
-
41
-
-
0035197286
-
MGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-d-aspartate receptors
-
11123360 1:CAS:528:DC%2BD3MXosVWn
-
Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PG, Knoblach SM, Faden AI (2001) mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-d-aspartate receptors. J Pharmacol Exp Ther 296:41-47
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 41-47
-
-
Movsesyan, V.A.1
O'Leary, D.M.2
Fan, L.3
Bao, W.4
Mullins, P.G.5
Knoblach, S.M.6
Faden, A.I.7
-
42
-
-
79954614494
-
Metabotropic glutamate receptors: From the workbench to the bedside
-
21036182 10.1016/j.neuropharm.2010.10.022 1:CAS:528:DC%2BC3MXkvVKisbo%3D
-
Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP (2011) Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology 60:1017-1041
-
(2011)
Neuropharmacology
, vol.60
, pp. 1017-1041
-
-
Nicoletti, F.1
Bockaert, J.2
Collingridge, G.L.3
Conn, P.J.4
Ferraguti, F.5
Schoepp, D.D.6
Wroblewski, J.T.7
Pin, J.P.8
-
43
-
-
25444467734
-
Critical assessment of how to study addiction and its treatment: Human and non-human animal models
-
16183393 10.1016/j.pharmthera.2005.06.018
-
O'Brien CP, Gardner EL (2005) Critical assessment of how to study addiction and its treatment: human and non-human animal models. Pharmacol Ther 108:18-58
-
(2005)
Pharmacol Ther
, vol.108
, pp. 18-58
-
-
O'Brien, C.P.1
Gardner, E.L.2
-
44
-
-
0033638723
-
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
-
11090117 10.1038/sj.bjp.0703715
-
O'Leary DM, Movsesyan V, Vicini S, Faden AI (2000) Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131:1429-1437
-
(2000)
Br J Pharmacol
, vol.131
, pp. 1429-1437
-
-
O'Leary, D.M.1
Movsesyan, V.2
Vicini, S.3
Faden, A.I.4
-
45
-
-
13444291828
-
The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase Cε-dependent mechanism
-
15548766 10.1124/mol.104.003319 1:CAS:528:DC%2BD2MXhtVWrs7o%3D
-
Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO (2005) The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase Cε-dependent mechanism. Mol Pharmacol 67:349-355
-
(2005)
Mol Pharmacol
, vol.67
, pp. 349-355
-
-
Olive, M.F.1
McGeehan, A.J.2
Kinder, J.R.3
McMahon, T.4
Hodge, C.W.5
Janak, P.H.6
Messing, R.O.7
-
46
-
-
36349011790
-
Self-administration of drugs in animals and humans as a model and an investigative tool
-
18031422 10.1111/j.1360-0443.2007.02011.x
-
Panlilio LV, Goldberg SR (2007) Self-administration of drugs in animals and humans as a model and an investigative tool. Addiction 102:1863-1870
-
(2007)
Addiction
, vol.102
, pp. 1863-1870
-
-
Panlilio, L.V.1
Goldberg, S.R.2
-
47
-
-
17744383991
-
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
-
15619120 10.1007/s00213-004-2070-9 1:CAS:528:DC%2BD2MXjtV2itL4%3D
-
Paterson NE, Markou A (2005) The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology 179:255-261
-
(2005)
Psychopharmacology
, vol.179
, pp. 255-261
-
-
Paterson, N.E.1
Markou, A.2
-
48
-
-
0019957859
-
Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study
-
7042771 10.1097/00004714-198204000-00010 1:STN:280:DyaL387ptVCqtA%3D%3D
-
Pecknold JC, McClure DJ, Appeltauer L, Wrzesinski L, Allan T (1982) Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study. J Clin Psychopharmacol 2:129-133
-
(1982)
J Clin Psychopharmacol
, vol.2
, pp. 129-133
-
-
Pecknold, J.C.1
McClure, D.J.2
Appeltauer, L.3
Wrzesinski, L.4
Allan, T.5
-
49
-
-
51249102144
-
Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: Comparison with dizocilpine
-
18509621 10.1007/s00213-008-1191-y 1:CAS:528:DC%2BD1cXhtFOjsLbK
-
Platt DM, Rowlett JK, Spealman RD (2008) Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine. Psychopharmacology 200:167-176
-
(2008)
Psychopharmacology
, vol.200
, pp. 167-176
-
-
Platt, D.M.1
Rowlett, J.K.2
Spealman, R.D.3
-
50
-
-
27144537834
-
Fenobam: A clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
-
16040814 10.1124/jpet.105.089839 1:CAS:528:DC%2BD2MXhtFyhtr7F
-
Porter RH, Jaeschke G, Spooren W, Ballard TM, Buttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Muhlemann A, Gatti S, Mutel V, Malherbe P (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315:711-721
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 711-721
-
-
Porter, R.H.1
Jaeschke, G.2
Spooren, W.3
Ballard, T.M.4
Buttelmann, B.5
Kolczewski, S.6
Peters, J.U.7
Prinssen, E.8
Wichmann, J.9
Vieira, E.10
Muhlemann, A.11
Gatti, S.12
Mutel, V.13
Malherbe, P.14
-
51
-
-
79952936972
-
MGluR5 negative allosteric modulators overview: A medicinal chemistry approach towards a series of novel therapeutic agents
-
Rocher JP, Bonnét B, Boléa C, Lütjens R, Le Poul E, Poli S, Epping-Jordan M, Bessis AS, Ludwig B, Mutel V (2011) mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents. Curr Top Med Chem 11:680-695
-
(2011)
Curr Top Med Chem
, vol.11
, pp. 680-695
-
-
Rocher Jp, B.1
-
52
-
-
0029872230
-
Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: Protein, mRNA splice variants, and regional distribution
-
8698900 10.1002/(SICI)1096-9861(19960408)367:3<403: AID-CNE6>3.0.CO;2-9 1:CAS:528:DyaK28Xis1Oitbc%3D
-
Romano C, van den Pol AN, O'Malley KL (1996) Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution. J Comp Neurol 367:403-412
-
(1996)
J Comp Neurol
, vol.367
, pp. 403-412
-
-
Romano, C.1
Van Den Pol, A.N.2
O'Malley, K.L.3
-
53
-
-
77954956744
-
A mGluR5 antagonist under clinical development improves l-DOPA-induced dyskinesia in parkinsonian rats and monkeys
-
20452425 10.1016/j.nbd.2010.05.001 1:CAS:528:DC%2BC3cXpt12nu7w%3D
-
Rylander D, Iderberg H, Li Q, Dekundy A, Zhang J, Li H, Baishen R, Danysz W, Bezard E, Cenci MA (2010) A mGluR5 antagonist under clinical development improves l-DOPA-induced dyskinesia in parkinsonian rats and monkeys. Neurobiol Dis 39:352-361
-
(2010)
Neurobiol Dis
, vol.39
, pp. 352-361
-
-
Rylander, D.1
Iderberg, H.2
Li, Q.3
Dekundy, A.4
Zhang, J.5
Li, H.6
Baishen, R.7
Danysz, W.8
Bezard, E.9
Cenci, M.A.10
-
54
-
-
0026101131
-
Clinical features of cocaine-induced paranoia
-
2006696 1:STN:280:DyaK3M7nsVSrtA%3D%3D
-
Satel SL, Southwick SM, Gawin FH (1991) Clinical features of cocaine-induced paranoia. Am J Psychiatry 148:495-498
-
(1991)
Am J Psychiatry
, vol.148
, pp. 495-498
-
-
Satel, S.L.1
Southwick, S.M.2
Gawin, F.H.3
-
55
-
-
0027395275
-
Metabotropic glutamate receptors in brain function and pathology
-
7680175 10.1016/0165-6147(93)90107-U 1:CAS:528:DyaK3sXhvVemsbc%3D
-
Schoepp DD, Conn PJ (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14:13-20
-
(1993)
Trends Pharmacol Sci
, vol.14
, pp. 13-20
-
-
Schoepp, D.D.1
Conn, P.J.2
-
56
-
-
0027378595
-
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
-
8295733 10.1016/0304-3940(93)90227-C 1:CAS:528:DyaK2cXisVWitg%3D%3D
-
Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N (1993) Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163:53-57
-
(1993)
Neurosci Lett
, vol.163
, pp. 53-57
-
-
Shigemoto, R.1
Nomura, S.2
Ohishi, H.3
Sugihara, H.4
Nakanishi, S.5
Mizuno, N.6
-
57
-
-
5144233794
-
Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity
-
15482908 10.1016/j.bmcl.2004.09.018 1:CAS:528:DC%2BD2cXos1ejurY%3D
-
Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND (2004) Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity. Bioorg Med Chem Lett 14:5481-5484
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 5481-5484
-
-
Smith, N.D.1
Poon, S.F.2
Huang, D.3
Green, M.4
King, C.5
Tehrani, L.6
Roppe, J.R.7
Chung, J.8
Chapman, D.P.9
Cramer, M.10
Cosford, N.D.11
-
58
-
-
84867902934
-
Increased vulnerability to cocaine in mice lacking dopamine D3 receptors
-
23045656 10.1073/pnas.1205297109 1:CAS:528:DC%2BC38XhvVSltLbJ
-
Song R, Zhang HY, Li X, Bi GH, Gardner EL, Xi ZX (2012) Increased vulnerability to cocaine in mice lacking dopamine D3 receptors. Proc Natl Acad Sci USA 109:17675-17680
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 17675-17680
-
-
Song, R.1
Zhang, H.Y.2
Li, X.3
Bi, G.H.4
Gardner, E.L.5
Xi, Z.X.6
-
59
-
-
28244486818
-
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: A possible key mechanism in the modulation of N-methyl-d-aspartate effects
-
16271052 10.1111/j.1471-4159.2005.03455.x 1:CAS:528:DC%2BD2MXht1OnsbrK
-
Tebano MT, Martire A, Rebola N, Pepponi R, Domenici MR, Gro MC, Schwarzschild MA, Chen JF, Cunha RA, Popoli P (2005) Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-d-aspartate effects. J Neurochem 95:1188-1200
-
(2005)
J Neurochem
, vol.95
, pp. 1188-1200
-
-
Tebano, M.T.1
Martire, A.2
Rebola, N.3
Pepponi, R.4
Domenici, M.R.5
Gro, M.C.6
Schwarzschild, M.A.7
Chen, J.F.8
Cunha, R.A.9
Popoli, P.10
-
60
-
-
19244387486
-
Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking
-
15363959 10.1016/j.ejphar.2004.07.056 1:CAS:528:DC%2BD2cXnsFSqu74%3D
-
Tessari M, Pilla M, Andreoli M, Hutcheson DM, Heidbreder CA (2004) Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur J Pharmacol 499:121-133
-
(2004)
Eur J Pharmacol
, vol.499
, pp. 121-133
-
-
Tessari, M.1
Pilla, M.2
Andreoli, M.3
Hutcheson, D.M.4
Heidbreder, C.A.5
-
61
-
-
0033004276
-
SIB-1757 and SIB-1893: Selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
-
10381773 1:CAS:528:DyaK1MXktFKis7c%3D
-
Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Velicelebi G, Johnson EC (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther 290:170-181
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 170-181
-
-
Varney, M.A.1
Cosford, N.D.2
Jachec, C.3
Rao, S.P.4
Sacaan, A.5
Lin, F.F.6
Bleicher, L.7
Santori, E.M.8
Flor, P.J.9
Allgeier, H.10
Gasparini, F.11
Kuhn, R.12
Hess, S.D.13
Velicelebi, G.14
Johnson, E.C.15
-
62
-
-
20044391431
-
Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: A role in stress-induced relapse to drug seeking
-
15930388 10.1523/JNEUROSCI.0955-05.2005 1:CAS:528:DC%2BD2MXlt1ygu7k%3D
-
Wang B, Shaham Y, Zitzman D, Azari S, Wise RA, You ZB (2005) Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. J Neurosci 25:5389-5396
-
(2005)
J Neurosci
, vol.25
, pp. 5389-5396
-
-
Wang, B.1
Shaham, Y.2
Zitzman, D.3
Azari, S.4
Wise, R.A.5
You, Z.B.6
-
63
-
-
34347402784
-
2 receptor and CRF-binding protein in the ventral tegmental area of the rat
-
17437087 10.1007/s00213-007-0782-3 1:CAS:528:DC%2BD2sXntFGqt7s%3D
-
2 receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology 193:283-294
-
(2007)
Psychopharmacology
, vol.193
, pp. 283-294
-
-
Wang, B.1
You, Z.B.2
Rice, K.C.3
Wise, R.A.4
-
64
-
-
84871791218
-
Role of mGluR5 neurotransmission in reinstated cocaine-seeking
-
22340009 10.1111/j.1369-1600.2011.00432.x
-
Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW (2013) Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol 18:40-49
-
(2013)
Addict Biol
, vol.18
, pp. 40-49
-
-
Wang, X.1
Moussawi, K.2
Knackstedt, L.3
Shen, H.4
Kalivas, P.W.5
-
65
-
-
84872285950
-
Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator
-
22820868 10.1007/s00213-012-2804-z 1:CAS:528:DC%2BC38XhtVOisb3M
-
Watterson LR, Kufahl PR, Nemirovsky NE, Sewalia K, Hood LE, Olive MF (2013) Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator. Psychopharmacology 225:151-159
-
(2013)
Psychopharmacology
, vol.225
, pp. 151-159
-
-
Watterson, L.R.1
Kufahl, P.R.2
Nemirovsky, N.E.3
Sewalia, K.4
Hood, L.E.5
Olive, M.F.6
-
66
-
-
33748158341
-
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: Role of glutamate in the nucleus accumbens
-
16914679 10.1523/JNEUROSCI.0726-06.2006 1:CAS:528:DC%2BD28Xpt1Cks7g%3D
-
Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL (2006a) Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci 26:8531-8536
-
(2006)
J Neurosci
, vol.26
, pp. 8531-8536
-
-
Xi, Z.X.1
Gilbert, J.G.2
Peng, X.Q.3
Pak, A.C.4
Li, X.5
Gardner, E.L.6
-
67
-
-
33745193915
-
The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats
-
16205781 10.1038/sj.npp.1300912 1:CAS:528:DC%2BD28Xls1Kitr4%3D
-
Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR Jr, Gitajn L, Gardner EL (2006b) The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31:1393-1405
-
(2006)
Neuropsychopharmacology
, vol.31
, pp. 1393-1405
-
-
Xi, Z.X.1
Newman, A.H.2
Gilbert, J.G.3
Pak, A.C.4
Peng, X.Q.5
Ashby, Jr.C.R.6
Gitajn, L.7
Gardner, E.L.8
-
68
-
-
34848846897
-
A role for conditioned ventral tegmental glutamate release in cocaine seeking
-
17898226 10.1523/JNEUROSCI.2967-07.2007 1:CAS:528:DC%2BD2sXhtFGmt7fI
-
You ZB, Wang B, Zitzman D, Azari S, Wise RA (2007) A role for conditioned ventral tegmental glutamate release in cocaine seeking. J Neurosci 27:10546-10555
-
(2007)
J Neurosci
, vol.27
, pp. 10546-10555
-
-
You, Z.B.1
Wang, B.2
Zitzman, D.3
Azari, S.4
Wise, R.A.5
|