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Volumn 110, Issue 4, 2014, Pages 935-945

Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYPOSIS COLI; BETA CATENIN; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HEK293 CELLS; HT29 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM INVASIVENESS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84894383636     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.816     Document Type: Article
Times cited : (43)

References (48)
  • 1
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    • Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, Sizemore N (2005) The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene 24: 1021-1031.
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6    Sizemore, N.7
  • 3
    • 57149142495 scopus 로고    scopus 로고
    • The impact of o2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC (2008) The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 4
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Bienz M, Clevers H (2000) Linking colorectal cancer to Wnt signaling. Cell 103: 311-320.
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 6
    • 73249130655 scopus 로고    scopus 로고
    • Expression of hif-1alpha and vegf in colorectal cancer: Association with clinical outcomes and prognostic implications
    • Cao D, Hou M, Guan YS, Jiang M, Yang Y, Gou HF (2009) Expression of HIF-1alpha and VEGF in colorectal cancer: Association with clinical outcomes and prognostic implications. BMC Cancer 9: 432.
    • (2009) BMC Cancer , vol.9 , pp. 432
    • Cao, D.1    Hou, M.2    Guan, Y.S.3    Jiang, M.4    Yang, Y.5    Gou, H.F.6
  • 8
    • 33846675310 scopus 로고    scopus 로고
    • Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways
    • Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S (2007) Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res 67: 674-683.
    • (2007) Cancer Res , vol.67 , pp. 674-683
    • Cho, S.D.1    Yoon, K.2    Chintharlapalli, S.3    Abdelrahim, M.4    Lei, P.5    Hamilton, S.6    Khan, S.7    Ramaiah, S.K.8    Safe, S.9
  • 9
    • 1642494853 scopus 로고    scopus 로고
    • Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma
    • Choi JW, Park SC, Kang GH, Liu JO, Youn HD (2004) Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Res 64: 35-39.
    • (2004) Cancer Res , vol.64 , pp. 35-39
    • Choi, J.W.1    Park, S.C.2    Kang, G.H.3    Liu, J.O.4    Youn, H.D.5
  • 10
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 11
    • 0032530482 scopus 로고    scopus 로고
    • Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    • Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95: 11211-11216.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11211-11216
    • Delcommenne, M.1    Tan, C.2    Gray, V.3    Rue, L.4    Woodgett, J.5    Dedhar, S.6
  • 12
    • 41549133557 scopus 로고    scopus 로고
    • Nuclear dvl, c-jun, beta-catenin, and tcf form a complex leading to stabilization of beta-catenin-Tcf interaction
    • Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L (2008) Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol 180: 1087-1100.
    • (2008) J Cell Biol , vol.180 , pp. 1087-1100
    • Gan, X.Q.1    Wang, J.Y.2    Xi, Y.3    Wu, Z.L.4    Li, Y.P.5    Li, L.6
  • 18
    • 62149108987 scopus 로고    scopus 로고
    • Hypoxia or in situ normoxia: The stem cell paradigm
    • Ivanovic Z (2009) Hypoxia or in situ normoxia: The stem cell paradigm. J Cell Physiol 219: 271-275.
    • (2009) J Cell Physiol , vol.219 , pp. 271-275
    • Ivanovic, Z.1
  • 19
    • 33947217823 scopus 로고    scopus 로고
    • Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    • Kaidi A, Williams AC, Paraskeva C (2007) Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 9: 210-217.
    • (2007) Nat Cell Biol , vol.9 , pp. 210-217
    • Kaidi, A.1    Williams, A.C.2    Paraskeva, C.3
  • 20
    • 53049091279 scopus 로고    scopus 로고
    • Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of pi3k/akt pathway
    • Kang B, Hao C, Wang H, Zhang J, Xing R, Shao J, Li W, Xu N, Lu Y, Liu S (2008) Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway. J Proteome Res 7: 3507-3515.
    • (2008) J Proteome Res , vol.7 , pp. 3507-3515
    • Kang, B.1    Hao, C.2    Wang, H.3    Zhang, J.4    Xing, R.5    Shao, J.6    Li, W.7    Xu, N.8    Lu, Y.9    Liu, S.10
  • 26
    • 44949226873 scopus 로고    scopus 로고
    • Tumour-stroma interactions in colorectal cancer: Converging on beta-catenin activation and cancer stemness
    • Le NH, Franken P, Fodde R (2008) Tumour-stroma interactions in colorectal cancer: Converging on beta-catenin activation and cancer stemness. Br J Cancer 98: 1886-1893.
    • (2008) Br J Cancer , vol.98 , pp. 1886-1893
    • Le, N.H.1    Franken, P.2    Fodde, R.3
  • 27
    • 38849131230 scopus 로고    scopus 로고
    • TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
    • Li J, Wang CY (2008) TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat Cell Biol 10: 160-169.
    • (2008) Nat Cell Biol , vol.10 , pp. 160-169
    • Li, J.1    Wang, C.Y.2
  • 29
    • 0035947083 scopus 로고    scopus 로고
    • Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    • Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N (2001) Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7: 927-936.
    • (2001) Mol Cell , vol.7 , pp. 927-936
    • Liu, J.1    Stevens, J.2    Rote, C.A.3    Yost, H.J.4    Hu, Y.5    Neufeld, K.L.6    White, R.L.7    Matsunami, N.8
  • 30
    • 34547126693 scopus 로고    scopus 로고
    • PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-Terminal kinase pathway
    • Liu M, Li D, Aneja R, Joshi HC, Xie S, Zhang C, Zhou J (2007) PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-Terminal kinase pathway. J Biol Chem 282: 17581-17586.
    • (2007) J Biol Chem , vol.282 , pp. 17581-17586
    • Liu, M.1    Li, D.2    Aneja, R.3    Joshi, H.C.4    Xie, S.5    Zhang, C.6    Zhou, J.7
  • 33
    • 0035947080 scopus 로고    scopus 로고
    • Siah-1 SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    • Matsuzawa SI, Reed JC (2001) Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 7: 915-926.
    • (2001) Mol Cell , vol.7 , pp. 915-926
    • Matsuzawa, S.I.1    Reed, J.C.2
  • 35
    • 0028987249 scopus 로고
    • Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P (1995) Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 92: 3046-3050.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 37
    • 33751513321 scopus 로고    scopus 로고
    • Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway
    • Pon YL, Wong AS (2006) Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway. Mol Endocrinol 20: 3336-3350.
    • (2006) Mol Endocrinol , vol.20 , pp. 3336-3350
    • Pon, Y.L.1    Wong, A.S.2
  • 38
    • 79954431772 scopus 로고    scopus 로고
    • Cross-Talk between NR4A orphan nuclear receptors and beta-catenin signaling pathway in osteoblasts
    • Rajalin AM, Aarnisalo P (2011) Cross-Talk between NR4A orphan nuclear receptors and beta-catenin signaling pathway in osteoblasts. Arch Biochem Biophys 509: 44-51.
    • (2011) Arch Biochem Biophys , vol.509 , pp. 44-51
    • Rajalin, A.M.1    Aarnisalo, P.2
  • 39
    • 79960024581 scopus 로고    scopus 로고
    • Reciprocal influence of the p53 and the hypoxic pathways
    • Sermeus A, Michiels C (2011) Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis 2: E164.
    • (2011) Cell Death Dis , vol.2
    • Sermeus, A.1    Michiels, C.2
  • 40
    • 79956024918 scopus 로고    scopus 로고
    • Regulation of nr4a nuclear receptor expression by oncogenic braf in melanoma cells
    • Smith AG, Lim W, Pearen M, Muscat GE, Sturm RA (2011) Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res 24: 551-563.
    • (2011) Pigment Cell Melanoma Res , vol.24 , pp. 551-563
    • Smith, A.G.1    Lim, W.2    Pearen, M.3    Muscat, G.E.4    Sturm, R.A.5
  • 43
    • 7444271412 scopus 로고    scopus 로고
    • Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt
    • Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L (2004) Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci USA 101: 15370-15375.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15370-15375
    • Tian, Q.1    Feetham, M.C.2    Tao, W.A.3    He, X.C.4    Li, L.5    Aebersold, R.6    Hood, L.7
  • 44
  • 45
    • 0037031914 scopus 로고    scopus 로고
    • The activation function-1 domain of Nur77/NR4A1 mediates trans-Activation, cell specificity, and coactivator recruitment
    • Wansa KD, Harris JM, Muscat GE (2002) The activation function-1 domain of Nur77/NR4A1 mediates trans-Activation, cell specificity, and coactivator recruitment. J Biol Chem 277: 33001-33011.
    • (2002) J Biol Chem , vol.277 , pp. 33001-33011
    • Wansa, K.D.1    Harris, J.M.2    Muscat, G.E.3
  • 46
    • 77956875346 scopus 로고    scopus 로고
    • Comparison of beta-catenin with tgf-beta1 hif-1alpha and patients'disease-free survival in human colorectal cancer
    • Wincewicz A, Koda M, Sulkowski S, Kanczuga-Koda L, Sulkowska M (2010) Comparison of beta-catenin with TGF-beta1, HIF-1alpha and patients'disease-free survival in human colorectal cancer. Pathol Oncol Res 16: 311-318.
    • (2010) Pathol Oncol Res , vol.16 , pp. 311-318
    • Wincewicz, A.1    Koda, M.2    Sulkowski, S.3    Kanczuga-Koda, L.4    Sulkowska, M.5
  • 47
    • 0037477627 scopus 로고    scopus 로고
    • Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    • Wong AS, Gumbiner BM (2003) Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J Cell Biol 161: 1191-1203.
    • (2003) J Cell Biol , vol.161 , pp. 1191-1203
    • Wong, A.S.1    Gumbiner, B.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.