The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling

Gut

Volumn 61, Issue 5, 2012, Pages 714-724

  Chen, Hang Zi ^a   Liu, Qing Feng ^a   Li, Li ^a   Wang, Wei Jia ^a   Yao, Lu Ming ^a   Yang, Meng ^a   Liu, Bo ^a   Chen, Wei ^a   Zhan, Yan Yan ^a   Zhang, Ming Qing ^a   Cai, Jian Chun ^a   Zheng, Zhong Hui ^a   Lin, Sheng Cai ^a   Li, Bo An ^a   Wu, Qiao ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYTOSPORONE B; GLYCOGEN SYNTHASE KINASE 3BETA; NUCLEAR RECEPTOR NUR77; T CELL FACTOR 4 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL PROLIFERATION; CHROMATIN; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; INTESTINE EPITHELIUM CELL; INTESTINE POLYP; INTESTINE TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; BETA-GALACTOSIDASE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DOWN-REGULATION; GLYCOGEN SYNTHASE KINASE 3; INTESTINAL MUCOSA; INTESTINAL POLYPS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PHOSPHORYLATION; TUMOR MARKERS, BIOLOGICAL; WNT SIGNALING PATHWAY;

EID: 84859603974     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-300783     Document Type: Article

References (48)

1. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
2. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50. (Pubitemid 40558990)
3. Barker N, Clevers H. Catenins, Wnt signaling and cancer. Bioessays 2000;22:961-5.
4. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51. (Pubitemid 30639518)
5. Cook D, Fry MJ, Hughes K, et al. Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J 1996;15:4526-36. (Pubitemid 26294571)
6. Behrens J, von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996;382:638-42. (Pubitemid 26268958)
7. Molenaar M, van de WM, Oosterwegel M, et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 1996;86:391-9.
8. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000;103:311-20.
9. He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12. (Pubitemid 28425575)
10. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6. (Pubitemid 29180374)
11. Beildeck ME, Gelmann EP, Byers SW. Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway. Exp Cell Res 2010;316:1763-72.
12. Mulholland DJ, Dedhar S, Coetzee GA, et al. Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 2005;26:898-915. (Pubitemid 41770157)
13. Chesire DR, Isaacs WB. Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor. Oncogene 2002;21:8453-69. (Pubitemid 36054886)
14. Mulholland DJ, Read JT, Rennie PS, et al. Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. Oncogene 2003;22:5602-13. (Pubitemid 37102696)
15. Easwaran V, Pishvaian M, Salimuddin, et al. Cross-regulation of beta-catenin-LEF/ TCF and retinoid signaling pathways. Curr Biol 1999;9:1415-18.
16. Cianferotti L, Cox M, Skorija K, et al. Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc Natl Acad Sci U S A 2007;104:9428-33. (Pubitemid 47185796)
17. Palmer HG, Gonzalez-Sancho JM, Espada J, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 2001;154:369-87. (Pubitemid 34286147)
18. Hazel TG, Nathans D, Lau LF. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci U S A 1988;85:8444-8. (Pubitemid 19024988)
19. Chintharlapalli S, Burghardt R, Papineni S, et al. Activation of Nur77 by selected 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem 2005;280:24903-14. (Pubitemid 40934582)
20. Cho SD, Yoon K, Chintharlapalli S, et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res 2007;67:674-83. (Pubitemid 46192207)
21. Zhan Y, Du X, Chen H, et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol 2008;4:548-56.
22. Liu JJ, Zeng HN, Zhang LR, et al. A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro. Cancer Res 2010;70:3628-37.
23. Moll UM, Marchenko N, Zhang XK. p53 and Nur77/TR3-transcription factors that directly target mitochondria for cell death induction. Oncogene 2006;25:4725-43. (Pubitemid 44187622)
24. Kolluri SK, Bruey-Sedano N, Cao X, et al. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol 2003;23:8651-67. (Pubitemid 37433369)
25. Woronicz JD, Calnan B, Ngo V, et al. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 1994;367:277-81. (Pubitemid 24051144)
26. Li H, Kolluri SK, Gu J, et al. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 2000;289:1159-64. (Pubitemid 30650723)
27. Wu Q, Liu S, Ye XF, et al. Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells. Carcinogenesis 2002;23:1583-92. (Pubitemid 35214942)
28. Lin B, Kolluri SK, Lin F, et al. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 2004;116:527-40. (Pubitemid 38264430)
29. Lee SL, Wesselschmidt RL, Linette GP, et al. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science 1995;269:532-5.
30. Mullican SE, Zhang S, Konopleva M, et al. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med 2007;13:730-5. (Pubitemid 46889752)
31. Smith AG, Lim W, Pearen M, et al. Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res 2011;24:551-63.
32. Rajalin AM, Aarnisalo P. Cross-talk between NR4A orphan nuclear receptors and beta-catenin signaling pathway in osteoblasts. Arch Biochem Biophys 2011;509:44-51.
33. Maretto S, Cordenonsi M, Dupont S, et al. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 2003;100:3299-304. (Pubitemid 36356577)
34. Roose J, Huls G, van Beest M, et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science 1999;285:1923-6.
35. Korinek V, Barker N, Morin PJ, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997;275:1784-7. (Pubitemid 27136714)
36. Porfiri E, Rubinfeld B, Albert I, et al. Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene 1997;15:2833-9. (Pubitemid 28004572)
37. Willert K, Jones KA. Wnt signaling: is the party in the nucleus? Genes Dev 2006;20:1394-404. (Pubitemid 43830647)
38. Su LK, Kinzler KW, Vogelstein B, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256:668-70.
39. Wu H, Lin Y, Li W, et al. Regulation of Nur77 expression by {beta}-catenin and its mitogenic effect in colon cancer cells. FASEB J 2010;25:192-205.
40. Mai W, Kawakami K, Shakoori A, et al. Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin Cancer Res 2009;15:6810-19.
41. Shakoori A, Ougolkov A, Yu ZW, et al. Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun 2005;334:1365-73. (Pubitemid 41074725)
42. Kim HS, Skurk C, Thomas SR, et al. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem 2002;277:41888-96. (Pubitemid 35257501)
43. Taelman VF, Dobrowolski R, Plouhinec JL, et al. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 2010;143:1136-48.
44. Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 2006;25:7531-7. (Pubitemid 44885752)
45. Kitagawa H, Ray WJ, Glantschnig H, et al. A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling. Mol Cell Biol 2007;27:7486-96. (Pubitemid 350033655)
46. Arkenbout EK, de Waard V, van Bragt M, et al. Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice. Circulation 2002;106:1530-5.
47. Wilson AJ, Arango D, Mariadason JM, et al. TR3/Nur77 in colon cancer cell apoptosis. Cancer Res 2003;63:5401-7. (Pubitemid 37139857)
48. Rajamanickam S, Kaur M, Velmurugan B, et al. Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway. Pharm Res 2009;26:2558-67.