A disulfide tether stabilizes the block of sodium channels by the conotoxin μOS-GVIIJ

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages 2758-2763

  Gajewiak, Joanna ^a   Azam, Layla ^a   Imperial, Julita ^a   Walewska, Aleksandra ^a,e   Green, Brad R ^a   Bandyopadhyay, Pradip K ^a   Raghuraman, Shrinivasan ^a   Ueberheide, Beatrix ^b   Bern, Marshall ^c   Zhou, H Mimi ^d   Minassian, Natali A ^d   Hagan, Rebecca H ^d   Flinspach, Mack ^d   Liu, Yi ^d   Bulaj, Grzegorz ^a   Wickenden, Alan D ^d   Olivera, Baldomero M ^a   Yoshikami, Doju ^a   Zhang, Min Min ^a  

^a UNIVERSITY OF UTAH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c Protein Metrics Inc   (United States)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e UNIVERSITY OF GDA SK   (Poland)

Author keywords

Disulfide exchange; NaV subunit; S cysteinylation; Tethered toxin; Voltage gated sodium channel

Indexed keywords

DISULFIDE EXCHANGE; NAVΒ-SUBUNIT; S-CYSTEINYLATION; TETHERED TOXIN; VOLTAGE-GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONOTOXINS; CYSTEINE; DISULFIDES; DNA PRIMERS; DNA, COMPLEMENTARY; MOLECULAR SEQUENCE DATA; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; SEQUENCE ANALYSIS, DNA; TANDEM MASS SPECTROMETRY; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84894315310     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324189111     Document Type: Article

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