Molecular motions within the pore of voltage-dependent sodium channels

Biophysical Journal

Volumn 73, Issue 2, 1997, Pages 603-613

  Bénitah, Jean Pierre ^a   Ranjan, Ravi ^a   Yamagishi, Toshio ^a   Janecki, Maria ^a   Tomaselli, Gordon F ^a   Marban, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL;

ARTICLE; CHANNEL GATING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION; RAT; STRUCTURE ANALYSIS;

EID: 0342276134     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78096-2     Document Type: Article

References (38)

1. Armstrong, C. M. 1989. Reflections on selectivity. In Membrane Transport: People and Ideas. D. C. Tosteson, editor. Waverly Press, Baltimore, MD. 261-274.
2. Bénitah, J.-P., G. F. Tomaselli, and E. Marban. 1996. Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis. Proc. Natl. Acad. Sci. USA. 93:7392-7396.
3. Brooks, C. L., M. Karplus, and B. M. Pettitt. 1988. Proteins: a theoretical perspective of dynamics, structure, and thermodynamics. In Advances in Chemical Physics, Vol. 71. I. Prigogine and S. A. Rice, editors. Interscience Publication.
4. Careaga, C. L., and J. J. Falke. 1992. Thermal motions of surface α-helix in D-galactose chemosensory receptor: detection by disulfide trapping. J. Mol. Biol. 226:1219-1235.
5. Careaga, C. L., J. Sutherland, J. Sabeti, and J. J. Falke. 1995. Large amplitude twisting of an interdomain hinge: a disulfide trapping study of the galactose-glucose binding protein. Biochemistry. 34:3048-3055.
6. 2+ channels. J. Gen. Physiol. 108:363-374.
7. Chervitz, S. A., C. M. Lin, and J. J. Falke. 1995. Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface. Biochemistry. 34:9722-9733.
8. + channel revealed by cysteine mutagenesis. Neuron. 16:1037-1047.
9. Chiamvimonvat, N., M. T. Pérez-García, G. F. Tomaselli, and E. Marban. 1996b. Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels. J. Physiol. (Lond.). 491: 51-59.
10. Eisenman, G., and S. Krasne. 1975. The ion selectivity of carrier molecules, membranes and enzymes. In MTP International Review of Science, Biochemistry Series, Vol. 2. C. F. Fox, editor. Butterworths, London. 27-59.
11. Falke, J. J., and D. E. Koshland. 1987. Global flexibility in a sensory receptor: a site directed disulfide approach. Science. 237:1596-1600.
12. 2+ in the voltage-gated sodium channel. Biophys. J. 71(6):3110-3125.
13. French, R. J., E. Prusak-Sochaczewski, G. W. Zamponi, S. Becker, A. Shavantha Kularatna, and R. Horn. 1996. Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry. Neuron. 16:407-413.
14. + channel. In Ionic Channels and Genetic Diseases, Vol. 50, Society of General Physiologists Series. D. C. Dawson and R. A. Frizzell, editors. Rockefeller University Press, New York. 1-16.
15. Heinemann, S. H., H. Terlau, W. Stühmer, K. Imoto, and S. Numa. 1992. Calcium channel characteristics conferred on the sodium channel by single mutations. Nature. 356:441-443.
16. Hille, B. 1971. The permeability of the sodium channel to organic cations in myelinated nerve. J. Gen. Physiol. 58:599-619.
17. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed. Sinauer Associates, Sunderland, MA. 337-389.
18. Isom, L. L., K. S. De Jongh, D. E. Patton, B. F. X. Reber, J. Offord, H. Charbonneau, K. Walsh, A. L. Goldin, and W. A. Catteral. 1992. Primary structure and functional expression of the β1 subunit of the rat sodium channel. Science. 256:839-842.
19. Kamp, T. J., M. T. Pérez-García, and E. Marban. 1996. Enhancement of ionic current and charge movement by coespression of calcium channel β1a subunit with α1c subunit in a human embryonic kidney cell line. J. Physiol. (Lond.). 492:88-96.
20. + channel pore. Biophys. J. 72:117-126.
21. 2+ channel pore in rat phaeochromocytoma cells. J. Physiol. (Lond.). 466:657-682.
22. Levitt, M. 1989. Molecular dynamics of macromolecules in water. Chim. Scripta. 29A:197-203.
23. + channel. Biophys. J. 66:1-13.
24. + channel during gating. Neuron. 16:859-867.
25. Mullins, L. J. 1959. An analysis of conductance changes in squid axon. J. Gen. Physiol. 42:817-829.
26. Oae, S. 1991. Organic Sulfur Chemistry: Structure and Mechanism. J. T. Doi, editor. CRC Press, Boca Raton, FL. 203-281.
27. Pérez-García, M. T., N. Chiamvimonvat, E. Marban, and G. F. Tomaselli. 1996. Structure of the sodium channel pore revealed by serial cysteine mutagenesis. Proc. Natl. Acad. Sci. USA. 93:300-304.
28. Pérez-García, M. T., N. Chiamvimonvat, R. Ranjan, J. R. Balser, E. Marban, and G. F. Tomaselli. 1997. Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification. Biophys. J. 72:989-996.
29. Srinivasan, N., R. Sowdhamini, C. Ramakrishnan, and P. Balaram. 1990. Conformations of disulfide bridges in protein. Int. J. Pept. Protein Res. 36:147-155.
30. Terlau, H., S. H. Heinemann, W. Stühmer, M. Pusch, F. Conti, K. Imoto, and S. Numa. 1991. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett. 293:93-96.
31. Tomaselli, G. F., N. Chiamvimonvat, H. B. Nuss, J. R. Balser, M. T. Pérez-García, R. H. Xu, D. W. Orias, P. H. Backx, and E. Marban. 1995. A mutation in the pore of the sodium channel alters gating. Biophys. J. 68:1814-1827.
32. Trimmer, J. S., S. S. Copperman, S. A. Tomiko, J. Zhou, S. M. Crean, M. B. Boyle, R. G. Kallen, Z. Sheng, R. L. Barchi, F. J. Sigworth, R. H. Goodman, W. S. Agnew, and G. Mandel. 1989. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron. 3:33-49.
33. Tsushima, R. G., R. A. Li, and P. H. Backx. 1997. Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore. J. Gen. Physiol. 109:463-475.
34. Weiner, M. P., K. A. Felts, T. G. Simcox, and J. C. Brama. 1993. A method for the site-directed mono-and multi-mutagenesis of double stranded DNA. Gene. 126:35-41.
35. Wells, J. A. 1990. Additivity of mutational effects in proteins. Biochemistry. 29:8509-8512.
36. Yamagishi, T., M. Janecki, E. Marban, and G. F. Tomaselli. 1997. Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis. Biophys. J. 73:195-204.
37. Yang, N., A. L. George, and R. Horn. 1996. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16:113-122.
38. + channel in a non-conducting state. Biophys. J. 71:3083-3090.