Synergistic and antagonistic interactions between tetrodotoxin and μ-conotoxin in blocking voltage-gated sodium channels

Channels

Volumn 3, Issue 1, 2009, Pages 32-38

  Zhang, Min Min ^a   McArthur, Jeff R ^b   Azam, Layla ^a   Bulaj, Grzegorz ^a   Olivera, Baldomero M ^a   French, Robert J ^b   Yoshikami, Doju ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Conotoxin; Contratoxin; NaV1.2; Oocyte; Site 1; Sodium channel; Syntoxin; Tetrodotoxin; Voltage clamp

Indexed keywords

CONOTOXIN; MU CONOTOXIN; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; LIGAND; NERVE PROTEIN; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL, VOLTAGE GATED, TYPE II, ALPHA 1; SODIUM CHANNEL, VOLTAGE-GATED, TYPE II, ALPHA 1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; FEMALE; LIPID BILAYER; MEMBRANE CURRENT; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; OOCYTE; PROTEIN BINDING; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS; ANIMAL; BINDING SITE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; MUTATION; RAT;

ANIMALS; BINDING SITES; CONOTOXINS; KINETICS; LIGANDS; MEMBRANE POTENTIALS; MUTATION; NERVE TISSUE PROTEINS; OOCYTES; RATS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; XENOPUS;

EID: 66149151034     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.3.1.7500     Document Type: Article

References (25)

1. Catterall WA, Goldin AL, Waxman SG. International Union of Pharmacology XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacological reviews 2005; 57:397-409.
2. French RJ, Terlau H. Sodium channel toxins - receptor targeting and therapeutic potential. Curr Med Chem 2004; 11:3053-3064 (Pubitemid 39545574)
3. Wood JN, Boorman JP, Okuse K, Baker MD. Voltage-gated sodium channels and pain pathways. J Neurobiol 2004; 61:55-71. (Pubitemid 39287770)
4. Cestele S, Catterall WA. Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. Biochimie 2000; 82:883-892
5. Safo P, Rosenbaum T, Shcherbatko A, Choi DY, Han E, Toledo-Aral JJ, et al. Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci 2000; 20:76-80. (Pubitemid 30220493)
6. Al-Sabi A, McArthur J, Ostroumov V, French RJ. Marine toxins that target voltage-gated sodium channels. Mar Drugs 2006; 4:157-192 (Pubitemid 43763911)
7. Catterall WA. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 1980; 20:15-43.
8. Sato K, Ishida Y, Wakamatsu K, Kato R, Honda H, Ohizumi Y, et al. Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels. J Biol Chem 1991; 266:16989-16991 (Pubitemid 21907895)
9. Becker S, Prusak-Sochaczewski E, Zamponi G, Beck-Sickinger AG, Gordon RD, French RJ. Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry 1992; 31:8229-8238
10. Hui K, Lipkind G, Fozzard HA, French RJ. Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin. J Gen Physiol 2002; 119:45-54. (Pubitemid 34074592)
11. Bulaj G, West PJ, Garrett JE, Watkins M, Zhang MM, Norton RS, Smith BJ, Yoshikami D, Olivera BM. Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry 2005; 44:7259-7265 (Pubitemid 40656669)
12. Zhang MM, Fiedler B, Green BR, Catlin P, Watkins M, Garrett JE, et al. Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels. Biochemistry 2006; 45:3723-3732
13. Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, et al. Structure/function characterization of μ-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem 2007; 282:30699-30706 (Pubitemid 350035180)
14. French RJ, Horn R. Shifts of macroscopic current activation in partially blocked sodium channels. Interaction between the voltage sensor and a mu-conotoxin. In: Latorre R, Saez JC, eds. From Ion Channels to Cell-to-Cell Conversations. New York: Plenum Press 1997; 67-89.
15. French RJ, Prusak-Sochaczewski E, Zamponi GW, Becker S, Kularatna AS, Horn R. Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry. Neuron 1996; 16:407-413 (Pubitemid 26072373)
16. Heinemann SH, Terlau H, Imoto K. Molecular basis for pharmacological differences between brain and cardiac sodium channels. Pflugers Arch 1992; 422:90-92
17. Olivera BM, Rivier J, Scott JK, Hillyard DR, Cruz LJ. Conotoxins. J Biol Chem 1991; 266:22067-22070
18. Santarelli VP, Eastwood AL, Dougherty DA, Horn R, Ahern CA. A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. J Biol Chem 2007; 282:8044-8051 (Pubitemid 47093591)
19. Backx PH, Yue DT, Lawrence JH, Marban E, Tomaselli GF. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 1992; 257:248-251
20. Chen LQ, Chahine M, Kallen RG, Barchi RL, Horn R. Chimeric study of sodium channels from rat skeletal and cardiac muscle. FEBS letters 1992; 309:253-257
21. + channels revealed by cysteine mutagenesis. BiophysJ 1997; 73:1874-1884.
22. Choudhary G, Aliste MP, Tieleman DP, French RJ, Dudley SC Jr. Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels 2007; 1:344-352
23. Rao J, Lahiri J, Isaacs L, Weis RM, Whitesides GM. A trivalent system from vancomycin.D-ala-D-Ala with higher affinity than avidin.biotin. Science 1998; 280:708-711 (Pubitemid 28243338)
24. Krueger BK, Worley JF, 3rd, French RJ. Block of sodium channels in planar lipid bilayers by guanidium toxins and calcium. Are the mechanisms of voltage dependence the same? Ann NY Acad Sci 1986; 479:257-268
25. West PJ, Bulaj G, Garrett JE, Olivera BM, Yoshikami D. Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons. Biochemistry 2002; 41:15388-15393 (Pubitemid 36008149)