Use-dependent block of the voltage-gated Na+ channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivity

Journal of General Physiology

Volumn 140, Issue 4, 2012, Pages 435-454

  Huang, Chien Jung ^a   Schild, Laurent ^b   Moczydlowski, Edward G ^c,d  

^a VERTEX PHARMACEUTICALS   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c SANDIA NATIONAL LABORATORIES   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MUSCLE PROTEIN; SAXITOXIN; SCN4A PROTEIN, RAT; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ANIMAL; ARTICLE; CELL STRAIN HEK293; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; ION TRANSPORT; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; RAT; STATIC ELECTRICITY;

ANIMALS; CALCIUM; HEK293 CELLS; HUMANS; ION TRANSPORT; MUSCLE PROTEINS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RATS; SAXITOXIN; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STATIC ELECTRICITY; TETRODOTOXIN;

EID: 84870785539     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201210853     Document Type: Article

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