A cation-π interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block

Journal of Biological Chemistry

Volumn 282, Issue 11, 2007, Pages 8044-8051

  Santarelli, Vincent P ^a   Eastwood, Amy L ^b   Dougherty, Dennis A ^b   Horn, Richard ^a   Ahern, Christopher A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RINGS; ELECTROSTATIC POTENTIAL; TETRODOTOXIN (TTX); TONIC BLOCKS;

CYTOTOXICITY; ELECTROSTATICS; ENZYME INHIBITION; IONIC CONDUCTIVITY; NEURONS; POSITIVE IONS;

MOLECULAR INTERACTIONS;

AMINO ACID; AROMATIC CARBOXYLIC ACID; BENZENE; CATION; LEUCINE; PHENYLALANINE; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; TYROSINE; VOLTAGE GATED SODIUM CHANNEL; FLUORINE; LOCAL ANESTHETIC AGENT; MUSCLE PROTEIN; NA(V)1.4 PROTEIN, RAT; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; ELECTRIC POTENTIAL; FLUORINATION; GENE REPRESSION; HYDROPHOBICITY; IN VIVO STUDY; ION TRANSPORT; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTUM MECHANICS; SENSITIVITY ANALYSIS; ANIMAL; CHEMISTRY; CONFORMATION; DOSE RESPONSE; ELECTROPHYSIOLOGY; METABOLISM; OOCYTE; PROTEIN BINDING; RAT; TETRAHYMENA THERMOPHILA; XENOPUS;

ANESTHETICS, LOCAL; ANIMALS; CATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FLUORINE; MOLECULAR CONFORMATION; MUSCLE PROTEINS; OOCYTES; PHENYLALANINE; PROTEIN BINDING; RATS; SODIUM CHANNELS; TETRAHYMENA THERMOPHILA; TETRODOTOXIN; TYROSINE; XENOPUS;

EID: 34247267099     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611334200     Document Type: Article

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