-
1
-
-
33646764233
-
Marine toxins that target voltage-gated sodium channels
-
Al-Sabi A, McArthur J, Ostroumov V, French RJ. Marine toxins that target voltage-gated sodium channels. Mar Drugs 4: 157-192, 2006.
-
(2006)
Mar Drugs
, vol.4
, pp. 157-192
-
-
Al-Sabi, A.1
McArthur, J.2
Ostroumov, V.3
French, R.J.4
-
2
-
-
69849094291
-
De novo synthesis of modified saxitoxins for sodium ion channel study
-
Andresen BM, Du Bois J. De novo synthesis of modified saxitoxins for sodium ion channel study. J Am Chem Soc 131: 12524-12525, 2009.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 12524-12525
-
-
Andresen, B.M.1
Du Bois, J.2
-
3
-
-
0016811485
-
The structure of a crystalline derivative of saxitoxin. The structure of saxitoxin
-
Bordner J, Thiessen WE, Bates HA, Rapoport H. The structure of a crystalline derivative of saxitoxin. The structure of saxitoxin. J Am Chem Soc 97: 6008-6012, 1975.
-
(1975)
J Am Chem Soc
, vol.97
, pp. 6008-6012
-
-
Bordner, J.1
Thiessen, W.E.2
Bates, H.A.3
Rapoport, H.4
-
4
-
-
17144418482
-
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP
-
Bricelj VM, Connell L, Konoki K, Macquarrie SP, Scheuer T, Catterall WA, Trainer VL. Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature 434: 763-767, 2005.
-
(2005)
Nature
, vol.434
, pp. 763-767
-
-
Bricelj, V.M.1
Connell, L.2
Konoki, K.3
Macquarrie, S.P.4
Scheuer, T.5
Catterall, W.A.6
Trainer, V.L.7
-
5
-
-
18544378146
-
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels
-
Bulaj G, West PJ, Garrett JE, Watkins M, Zhang MM, Norton RS, Smith BJ, Yoshikami D, Olivera BM. Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry 44: 7259-7265, 2005.
-
(2005)
Biochemistry
, vol.44
, pp. 7259-7265
-
-
Bulaj, G.1
West, P.J.2
Garrett, J.E.3
Watkins, M.4
Zhang, M.M.5
Norton, R.S.6
Smith, B.J.7
Yoshikami, D.8
Olivera, B.M.9
-
6
-
-
0018873513
-
Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
-
Catterall WA. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 20: 15-43, 1980.
-
(1980)
Annu Rev Pharmacol Toxicol
, vol.20
, pp. 15-43
-
-
Catterall, W.A.1
-
7
-
-
29844438166
-
Nomenclature and structure-function relationships of voltage-gated sodium channels
-
International Union of Pharmacology. XLVII.
-
Catterall WA, Goldin AL, Waxman SG. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57: 397-409, 2005.
-
(2005)
Pharmacol Rev
, vol.57
, pp. 397-409
-
-
Catterall, W.A.1
Goldin, A.L.2
Waxman, S.G.3
-
8
-
-
0033731909
-
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
-
Cestele S, Catterall WA. Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. Biochimie 82: 883-892, 2000.
-
(2000)
Biochimie
, vol.82
, pp. 883-892
-
-
Cestele, S.1
Catterall, W.A.2
-
10
-
-
55749096772
-
Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule
-
Choudhary G, Aliste MP, Tieleman DP, French RJ, Dudley SC Jr. Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels 1: 344-352, 2007.
-
(2007)
Channels
, vol.1
, pp. 344-352
-
-
Choudhary, G.1
Aliste, M.P.2
Tieleman, D.P.3
French, R.J.4
Dudley Jr., S.C.5
-
11
-
-
0035997028
-
Energetic localization of saxitoxin in its channel binding site
-
Choudhary G, Shang L, Li X, Dudley SC Jr. Energetic localization of saxitoxin in its channel binding site. Biophys J 83: 912-919, 2002.
-
(2002)
Biophys J
, vol.83
, pp. 912-919
-
-
Choudhary, G.1
Shang, L.2
Li, X.3
Dudley Jr., S.C.4
-
12
-
-
12244288289
-
Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule
-
Choudhary G, Yotsu-Yamashita M, Shang L, Yasumoto T, Dudley SC Jr. Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule. Biophys J 84: 287-294, 2003.
-
(2003)
Biophys J
, vol.84
, pp. 287-294
-
-
Choudhary, G.1
Yotsu-Yamashita, M.2
Shang, L.3
Yasumoto, T.4
Dudley Jr., S.C.5
-
13
-
-
0032478818
-
+ conduction and selectivity
-
+ conduction and selectivity. Science 280: 69-77, 1998.
-
(1998)
Science
, vol.280
, pp. 69-77
-
-
Doyle, D.A.1
Morais Cabral, J.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
Cohen, S.L.6
Chait, B.T.7
MacKinnon, R.8
-
14
-
-
0033756777
-
Mu-Conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains
-
Dudley SC Jr, Chang N, Hall J, Lipkind G, Fozzard HA, French RJ. mu-Conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol 116: 679-690, 2000.
-
(2000)
J Gen Physiol
, vol.116
, pp. 679-690
-
-
Dudley Jr., S.C.1
Chang, N.2
Hall, J.3
Lipkind, G.4
Fozzard, H.A.5
French, R.J.6
-
16
-
-
44249086114
-
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7
-
Fiedler B, Zhang MM, Buczek O, Azam L, Bulaj G, Norton RS, Olivera BM, Yoshikami D. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol 75: 2334-2344, 2008.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 2334-2344
-
-
Fiedler, B.1
Zhang, M.M.2
Buczek, O.3
Azam, L.4
Bulaj, G.5
Norton, R.S.6
Olivera, B.M.7
Yoshikami, D.8
-
17
-
-
9144242506
-
Sodium channel toxins: Receptor targeting and therapeutic potential
-
French RJ, Terlau H. Sodium channel toxins: receptor targeting and therapeutic potential. Curr Med Chem 11: 3053-3064, 2004.
-
(2004)
Curr Med Chem
, vol.11
, pp. 3053-3064
-
-
French, R.J.1
Terlau, H.2
-
18
-
-
0002507958
-
The saxitoxins: Sources, chemistry, and pharmacology
-
edited by Hall S, Strichartz GR. Washington, DC: American Chemical Society
-
Hall S, Strichartz GR, Moczydlowski E, Ravindran A, Reichardt PB. The saxitoxins: sources, chemistry, and pharmacology. In: Marine Toxins (ACS Symposium Series 418), edited by Hall S, Strichartz GR. Washington, DC: American Chemical Society, 1990, p. 29-65.
-
(1990)
Marine Toxins (ACS Symposium Series 418)
, pp. 29-65
-
-
Hall, S.1
Strichartz, G.R.2
Moczydlowski, E.3
Ravindran, A.4
Reichardt, P.B.5
-
19
-
-
0026698250
-
Molecular basis for pharmacological differences between brain and cardiac sodium channels
-
Heinemann SH, Terlau H, Imoto K. Molecular basis for pharmacological differences between brain and cardiac sodium channels. Pflügers Arch 422: 90-92, 1992.
-
(1992)
Pflügers Arch
, vol.422
, pp. 90-92
-
-
Heinemann, S.H.1
Terlau, H.2
Imoto, K.3
-
20
-
-
0016782794
-
The receptor for tetrodotoxin and saxitoxin. A structural hypothesis
-
Hille B. The receptor for tetrodotoxin and saxitoxin. A structural hypothesis. Biophys J 15: 615-619, 1975.
-
(1975)
Biophys J
, vol.15
, pp. 615-619
-
-
Hille, B.1
-
22
-
-
0036141825
-
Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin
-
DOI 10.1085/jgp.119.1.45
-
Hui K, Lipkind G, Fozzard HA, French RJ. Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin. J Gen Physiol 119: 45-54, 2002. (Pubitemid 34074592)
-
(2002)
Journal of General Physiology
, vol.119
, Issue.1
, pp. 45-54
-
-
Hui, K.1
Lipkind, G.2
Fozzard, H.A.3
French, R.J.4
-
23
-
-
64349101308
-
Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion
-
Khoo KK, Feng ZP, Smith BJ, Zhang MM, Yoshikami D, Olivera BM, Bulaj G, Norton RS. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry 48: 1210-1219, 2009.
-
(2009)
Biochemistry
, vol.48
, pp. 1210-1219
-
-
Khoo, K.K.1
Feng, Z.P.2
Smith, B.J.3
Zhang, M.M.4
Yoshikami, D.5
Olivera, B.M.6
Bulaj, G.7
Norton, R.S.8
-
24
-
-
0035815713
-
Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation
-
Li RA, Ennis IL, French RJ, Dudley SC Jr, Tomaselli GF, Marban E. Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation. J Biol Chem 276: 11072-11077, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 11072-11077
-
-
Li, R.A.1
Ennis, I.L.2
French, R.J.3
Dudley Jr., S.C.4
Tomaselli, G.F.5
Marban, E.6
-
26
-
-
0034682616
-
KcsA crystal structure as framework for a molecular model of the Na(+) channel pore
-
Lipkind GM, Fozzard HA. KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry 39: 8161-8170, 2000.
-
(2000)
Biochemistry
, vol.39
, pp. 8161-8170
-
-
Lipkind, G.M.1
Fozzard, H.A.2
-
28
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
-
Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19: 1639-1662, 1998.
-
(1998)
J Comput Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
Huey, R.4
Hart, W.E.5
Belew, R.K.6
Olson, A.J.7
-
29
-
-
70349932423
-
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
-
Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30: 2583-2791, 2009.
-
(2009)
J Comput Chem
, vol.30
, pp. 2583-2791
-
-
Morris, G.M.1
Huey, R.2
Lindstrom, W.3
Sanner, M.F.4
Belew, R.K.5
Goodsell, D.S.6
Olson, A.J.7
-
30
-
-
52449117715
-
A stereoselective synthesis of (+)-gonyautoxin 3
-
Mulcahy JV, Du Bois J. A stereoselective synthesis of (+)-gonyautoxin 3. J Am Chem Soc 130: 12630-12631, 2008.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 12630-12631
-
-
Mulcahy, J.V.1
Du Bois, J.2
-
31
-
-
4644371696
-
An efficient total synthesis of optically active tetrodotoxin
-
Nishikawa T, Urabe D, Isobe M. An efficient total synthesis of optically active tetrodotoxin. Angew Chem Int Ed Engl 43: 4782-4785, 2004.
-
(2004)
Angew Chem Int Ed Engl
, vol.43
, pp. 4782-4785
-
-
Nishikawa, T.1
Urabe, D.2
Isobe, M.3
-
34
-
-
0033994386
-
Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA
-
Safo P, Rosenbaum T, Shcherbatko A, Choi DY, Han E, Toledo-Aral JJ, Olivera BM, Brehm P, Mandel G. Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci 20: 76-80, 2000.
-
(2000)
J Neurosci
, vol.20
, pp. 76-80
-
-
Safo, P.1
Rosenbaum, T.2
Shcherbatko, A.3
Choi, D.Y.4
Han, E.5
Toledo-Aral, J.J.6
Olivera, B.M.7
Brehm, P.8
Mandel, G.9
-
35
-
-
34247267099
-
A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block
-
Santarelli VP, Eastwood AL, Dougherty DA, Horn R, Ahern CA. A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. J Biol Chem 282: 8044-8051, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 8044-8051
-
-
Santarelli, V.P.1
Eastwood, A.L.2
Dougherty, D.A.3
Horn, R.4
Ahern, C.A.5
-
36
-
-
39349084860
-
Stereoselective and efficient total synthesis of optically active tetrodotoxin from D-glucose
-
Sato K, Akai S, Shoji H, Sugita N, Yoshida S, Nagai Y, Suzuki K, Nakamura Y, Kajihara Y, Funabashi M, Yoshimura J. Stereoselective and efficient total synthesis of optically active tetrodotoxin from D-glucose. J Org Chem 73: 1234-1242, 2008.
-
(2008)
J Org Chem
, vol.73
, pp. 1234-1242
-
-
Sato, K.1
Akai, S.2
Shoji, H.3
Sugita, N.4
Yoshida, S.5
Nagai, Y.6
Suzuki, K.7
Nakamura, Y.8
Kajihara, Y.9
Funabashi, M.10
Yoshimura, J.11
-
37
-
-
0016843222
-
The structure of saxitoxin
-
Letter
-
Schantz EJ, Ghazarossian VE, Schnoes HK, Strong FM, Springer JP, Pezzanite JO, Clardy J. The structure of saxitoxin (Letter). J Am Chem Soc 97: 1238, 1975.
-
(1975)
J Am Chem Soc
, vol.97
, pp. 1238
-
-
Schantz, E.J.1
Ghazarossian, V.E.2
Schnoes, H.K.3
Strong, F.M.4
Springer, J.P.5
Pezzanite, J.O.6
Clardy, J.7
-
38
-
-
0026072218
-
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
-
Terlau H, Heinemann SH, Stuhmer W, Pusch M, Conti F, Imoto K, Numa S. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett 293: 93-96, 1991.
-
(1991)
FEBS Lett
, vol.293
, pp. 93-96
-
-
Terlau, H.1
Heinemann, S.H.2
Stuhmer, W.3
Pusch, M.4
Conti, F.5
Imoto, K.6
Numa, S.7
-
39
-
-
0347989461
-
Conus Venoms: A Rich Source of Novel Ion Channel-Targeted Peptides
-
DOI 10.1152/physrev.00020.2003
-
Terlau H, Olivera BM. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84: 41-68, 2004. (Pubitemid 38049875)
-
(2004)
Physiological Reviews
, vol.84
, Issue.1
, pp. 41-68
-
-
Terlau, H.1
Olivera, B.M.2
-
40
-
-
11244296111
-
Modeling P-loops domain of sodium channel: Homology with potassium channels and interaction with ligands
-
Tikhonov DB, Zhorov BS. Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J 88: 184-197, 2005.
-
(2005)
Biophys J
, vol.88
, pp. 184-197
-
-
Tikhonov, D.B.1
Zhorov, B.S.2
-
41
-
-
0037168454
-
mu-Conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons
-
West PJ, Bulaj G, Garrett JE, Olivera BM, Yoshikami D. mu-Conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons. Biochemistry 41: 15388-15393, 2002.
-
(2002)
Biochemistry
, vol.41
, pp. 15388-15393
-
-
West, P.J.1
Bulaj, G.2
Garrett, J.E.3
Olivera, B.M.4
Yoshikami, D.5
-
43
-
-
53749086169
-
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA
-
Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry 47: 10940-10949, 2008.
-
(2008)
Biochemistry
, vol.47
, pp. 10940-10949
-
-
Yao, S.1
Zhang, M.M.2
Yoshikami, D.3
Azam, L.4
Olivera, B.M.5
Bulaj, G.6
Norton, R.S.7
-
45
-
-
35349024767
-
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels
-
Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, Bulaj G. Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem 282: 30699-30706, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 30699-30706
-
-
Zhang, M.M.1
Green, B.R.2
Catlin, P.3
Fiedler, B.4
Azam, L.5
Chadwick, A.6
Terlau, H.7
McArthur, J.R.8
French, R.J.9
Gulyas, J.10
Rivier, J.E.11
Smith, B.J.12
Norton, R.S.13
Olivera, B.M.14
Yoshikami, D.15
Bulaj, G.16
-
46
-
-
66149151034
-
Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels
-
Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, Yoshikami D. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels 3: 32-38, 2009.
-
(2009)
Channels
, vol.3
, pp. 32-38
-
-
Zhang, M.M.1
McArthur, J.R.2
Azam, L.3
Bulaj, G.4
Olivera, B.M.5
French, R.J.6
Yoshikami, D.7
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